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Biomedical subjects

R Jensen

Publications and source records attributed to R Jensen.

At least 199 records · Page 11Linked to original sources

Excretory urography with glucagon: a randomized trial.

The authors compared the effect of glucagon (1 mg I.V.) and a placebo on visualization of the collecting systems and ureters in 185 adults undergoing routine excretory urography. Either glucagon or the placebo was given 10 minutes after contrast injection in the first 95 patients and 5 minutes after contrast injection in the remaining 90 patients. Ampules were randomized. Objective and subjective analysis showed no improvement in visualization of either the collecting systems or the ureters in either group: in fact, glucagon caused the quality of the urograms to decrease significantly. Possible reasons for this are discussed. No side effects attributable to the glucagon were observed.

Clinical Trials as Topic↗

Encephalitic sarcocystosis in a newborn calf.

Sporozoan schizonts were seen in histologic sections of cerebrum from a Hereford calf that died immediately after birth. Schizonts appeared in endothelial cells of small vessels in the gray and white matter. Rosette and palisade configurations of merozoites in schizonts, as well as the size of schizonts (15 to 40 X 21 microns) and merozoites (8 microns), resembled Sarcocystis stages described in cattle, and differentiated the organisms from Toxoplasma that infects nerve cells and undergoes endodyogeny. Specific identification of the infecting agent was not successful because tests of sera from the calf were not possible. Developmental, morphologic, and ultrastructural differences in schizogonic stages of the heteroxenous sporozoan species infecting cattle are poorly known and are presently unreliable criteria for species identification. Encephalitis, meningitis, and necrosis occurred in cerebral, cerebellar, and brain stem gray and white matter infiltrated with plasmacytes, lymphocytes, and macrophages. Microthrombi were often seen in small blood vessels within the reaction foci. Herd-mate sera tested against S cruzi were negative. The herd from which the calf was born was exposed to a variety of free-ranging domestic, feral, and wild scavengers with free access to dead range animals. Consequently, the cattle were undoubtedly exposed to infective cysts in feed or water contaminated by feces from carnivores.

Animals↗

Role of predominant rumen bacteria in the cause of polioencephalomalacia (cerebrocortical necrosis) in cattle.

Rumen contents of 2 heifers with acute polioencephalomalacia (cerebrocortical necrosis) were compared with rumen contents from a healthy steer fed a fibrous diet. Also examined were (i) the quantitative nature of the predominant rumen microflora, (ii) the distribution of morphologic types of bacteria in the rumen contents, (iii) the extent that morphologic groups produced or degraded thiamine, and (iv) the cumulative effects of metabolic activities of the predominant rumen bacteria concerning the net production or degradation of thiamine. The differences in the frequency of occurrence of particular bacterial morphologic groups, the extent of growth, and the amount of thiamine metabolism in relationship to growth were also evaluated. The cumulative thiamine metabolism of the predominant bacteria associated with the rumen of polioencephalomalacia-affected heifers led to substantial net thiamine destruction, whereas metabolism associated with the rumen of a normal steer led to thiamine production. Polioencephalomalacia may occur as a consequence of alteration of the metabolic activities of the predominant resident ruminal bacteria associated with diseased cattle.

Animals↗

Middle ear infection in feedlot lambs.

Of 133 feedlot lambs that died and were necropsied, 67 had normal lungs and 66 had pneumonic lungs. The middle ears of all lambs were opened by a specified technique. Of the 67, 8 (12%) had otitis media, and of the 66, 26 (39%) had otitis media. The difference in prevalence in the 2 groups was highly significant (P less than 0.005). In acute stages, the mucosae of tympanic cavities and tympanic membranes were inflamed and the cavities contained fluid, whereas in later stages lumens were partially filled with exudate. In chronic stages, however, exudate remained in lumens and mucosae were thick and rough. None of the tympanic membranes was ruptured, and none of the external acoustic meatuses contained exudate. The infected ears of 24 lambs were cultured and Pasteurella haemolytica was isolated from 18, and P multocida from 3. The infections probably ascended from the pharynx through the auditive tubes into the tympanic cavities.

Animals↗

Ram epididymitis: A clinical report.

Two hundred and five ram lambs originating from several sources were assembled for a ram performance trial. All rams were immunized with a commercial Brucella ovis bacterin. Four rams developed clinical evidence of epididymitis during the 150 day trial. Actinobacillus seminis was identified as the causative agent.

Journal Article↗

The rehabilitation of coronary surgical patients.

Coronary revascularization has been reported to have failed to effectively rehabilitate working-age patients. This study of 565 patients demonstrates that motivation to return to work is strongly influences by age and educational level. Patients under age 55 are more likely to return to work than are patients over that age, but preoperative job classification does not influence rehabilitation. Although preoperative disability was associated with a slightly lower return-to-work rate (90%) than was the case with patients working preoperatively (97%) preoperative retirement was a strongly negative influence on rehabilitation. In this study, 80% of the patients worked to or beyond retirement age, and duration of work was not influenced by preoperative disability. The salary produced by those patients who were rehabilitated by surgery was four and a half times greater than the total cost of care and disability payments for the entire patient population. The factors which seemed to be the most important in effective rehabilitation were the psychological preparation of patients and their families and the attitude toward rehabilitation expressed by physicians and employers.

Adult↗

Ischemia: a cause of hepatic telangiectasis in cattle.

We histologically examined (i) 73 bovine livers condemned by packing house inspectors for telangiectasis, (ii) 15 bovine livers passed by the same inspectors as normal, and (iii) 8 livers from cattle given an injection into their mesenteric veins: 6 with a suspension of agar particles containing viable Haemophilus somnus and 2 with diluent only. The injected cattle were killed and necropsied 2 to 12 days after the inoculations. Of the 73 telangiectatic livers, 57 (78%) had thrombosed and occluded or contracted and empty portal veins (venopathies), whereas 1 of the 15 normal livers contained one microscopic focus of telangiectasis and nearby venopathy. Of the 6 livers injected with suspended particles, all had venopathies and telangiectasis and the 2 control livers had neither.

Animals↗

Structural requirements of sterols for myelin tube formation with sodium oleate.

Cholesterol crystals treated with an aqueous solution of sodium oleate give rise to cylindrical lamellar associations which appear under the microscope as rapidly growing tubes. Myelin forms are also obtained with other membrane sterols (desmosterol, cholestanol, 7-dehydrocholesterol) but not with lanosterol, a metabolic precursor of cholesterol, nor with the catabolic products of cholesterol (coprosterol, cholecalciferol, pregnenolone). The structural requirements for obtaining myelin tubes from sterols and sodium oleate closely agree with the results obtained by studying sterol-lecithin associations using other experimental techniques (unimolecular films at the air/water interface and permeability of liposomes), association of sterols with an erythrocyte protein and cholesterol liquid crystals.

Chemical Phenomena↗

Lithium carbonate in patients with small cell lung cancer receiving combination chemotherapy.

Lithium administration has been shown to attenuate the leukopenia associated with systemic chemotherapy. The results of a randomized trial of lithium in 45 patients with small cell lung cancer who received combination chemotherapy and radiation therapy are reported. Patients randomized to receive lithium were started on 300 mg three times daily for 18 days of every 21 day chemotherapy cycle. Patients who received lithium experienced significantly less mid-cycle leukocyte and neutrophil count depression and spent fewer days with leukopenia and neutropenia than control patients regardless of age or extent of disease. Patients who received lithium spent fewer days hospitalized and fewer days with fever in the presence of severe neutropenia than control patients. The cumulative risk of fever with signs of infection was greater in control patients regardless of age, disease extent or the presence of marrow involvement. Patients who were given lithium received significantly more chemotherapy than control patients. Patient survival was greatest in those with limited disease, in complete responders and in those who received more than 75 percent of their induction chemotherapy although it did not differ between the two study groups. The majority of patients required either reduction or discontinuation of lithium. Those who received lithium continuously demonstrated a higher objective response rate and longer survival than either patients in whom the lithium had to be discontinued or those randomized to the control group. Infection was an important cause of death in the control group and cardiovascular event occurred frequently in the lithium group, but the major cause of death in this patient population remains progressive malignant disease.

Carcinoma, Small Cell↗

Preoperative embolization of renal tumours using balloon catheters.

Preoperative embolization was used in a series of 13 patients for reducing the bleeding during operation of even very large renal carcinomas. During and after embolization pain occurred which necessitated treatment. Balloon catheter embolization was used which excludes the risk of reflux of embolizing material to the aorta. It caused none or only minor injury to the renal arterial wall. No serious complication occurred.

Adult↗

Laryngeal diphtheria and papillomatosis in feedlot cattle.

In a random sample of 30,444 larynges from slaughtered beef cattle, 441 (1.4%) had chronic diphtheria and 1,345 (4.4%) had papillomatosis. Both types of lesions were centered in mucous membranes over the vocal processes and medial angles of the arytenoid cartilages. Since they are found in the same anatomical locations as laryngeal contact ulcers, we hypothesize that ulcers are primary and diphtheria and papillomatosis are secondary.

Animals↗

Osteochondrosis in feedlot cattle.

Beginning in summer 1977 and continuing through four consecutive seasons, we examined lame limb joints from 106 partially fattened cattle and 28,235 pairs of occipital condyles from fully fattened cattle for osteochondrosis. Of the 106 lame cattle, nine (8.5%) had characteristic lesions, usually in their stifle joints, and of the 28,235 atlanto-occipital joints, 1063 (3.8%) had lesions on their condyles. Slices of affected articular cartilage and subjacent bone were studied radiographically and histologically. Radiographs showed subchondral defects and epiphyseal "cyst-like" lesions, and histologic sections showed disarrayed and degenerated chondrocytes. Splits occurred along osteochondral junctions or in adjacent cartilage or bone. Some bone trabeculae had been replaced by fibrous tissue that, in some areas, extended deep into epiphyses.

Animals↗

Laryngeal contact ulcers in feedlot cattle.

Of 30,444 larynges from fattened cattle at three companies, 3,985 (13.1%) had contact ulcers or ulcer scars in the mucous membranes over the vocal processes and medial angles of the arytenoid cartilages. The incidence was higher in cattle fed during fall than in cattle fed during other seasons. We hypothesize: 1. that some feedlot cattle develop acute mucositis from mixed infections with species of Pasteurella, Haemophilus, Mycoplasma, and viruses in the nose, pharynx, and larynx; 2. that reflex coughing and swallowing accelerate the rate of larynx closure; and 3. that the closures erode the swollen membrane over the vocal processes and medial angles of the arytenoid cartilages and thus produce primary contact ulcers.

Animals↗