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R Jennings

Publications and source records attributed to R Jennings.

155 records · Page 9Linked to original sources
PubMedDate not supplied

Vaccination prevents latent HSV1 infection of mouse brain.

Herpes simplex encephalitis (HSE) is a rare but very serious disorder caused by herpes simplex type 1 virus (HSV-1). Treatment with acyclovir decreases mortality but many patients still suffer cognitive impairment subsequently. A vaccine against HSV1 would therefore be of great value. HSV-1 has been implicated also in Alzheimer's disease (AD): we established that HSV1 resides in the brain of about two thirds of AD patients and aged normal people, and that in carriers of the type 4 allele of the apolipoprotein E gene, it is a strong risk factor for AD. Thus a vaccine against HSV-1 might prevent development of AD in some cases. To find whether a vaccine of mixed HSV-1 glycoproteins (ISCOMs), which protects mice from latent HSV-1 infection of sensory ganglia, prevents HSV1 latency in the CNS, ISCOM-vaccinated or unvaccinated animals were infected with HSV-1. Using polymerase chain reaction (PCR) we detected HSV-1 in brain from 16 of 39 unvaccinated mice (41%), but only 3 of 41 vaccinated mice (7%) (P < 0.001). Thus, ISCOMs protect the CNS also, suggesting their possible future usage in humans.

Alzheimer Disease↗
PubMedDate not supplied

On the significance of very small angle scattered radiation to radiographic imaging at low energies.

We have studied the angular distribution of scattered radiation at low energies for angles between 2 degrees and 15 degrees from the outward normal to the exit surface of several phantoms, with 1 degree resolution. A cryogenically cooled germanium detector was used to measure the spectra of the scattered radiation. The differential scattering fluences, or numbers of photons per unit solid angle per unit surface area, exhibit distinct peaks at angles in the vicinity of 5 degrees, with the angular position being only slightly energy dependent but very material dependent. The scattered spectra show large changes as a function of angle, in some cases actually becoming harder than the exit unscattered beam. The significance of this behavior relative to the imaging of targets in mammography examinations is discussed.

Humans↗
PubMedDate not supplied

An approach to specifying a minimum dose system for mammography using multiparameter optimization techniques.

Analytical expressions have been written for image quality in mammography. Multiparameter optimizations have been conducted to find mammography systems providing the lowest patient dose for a given image quality. The optimizations are subject to constraints imposed by technology, such as power limits on the tube focal spot, absorption efficiency related to detector resolution, and others. The optimizations permit system geometry, kVp, filtration, detector resolution, focal spot size, and grid characteristics to vary simultaneously and self-consistently subject to the constraints. A system configuration approaching a factor of 3 dose reduction has been found without assuming radical technological advances. The system satisfies image quality constraints for both large and small targets and would be possible to implement clinically. The sensitivity of the results to the assumptions made in the modeling has been investigated.

Body Burden↗
PubMedDate not supplied

The first ten days.

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Humans↗