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Biomedical subjects

R Jean

Publications and source records attributed to R Jean.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

[Yellow nail syndrome associated with intestinal lymphangiectasia].

The yellow nail syndrome, a combination of yellow discoloured nails, lymphedema and pleural effusions, is a rare clinical condition. We report a case of the yellow nail syndrome associated with intestinal lymphangiectasia revealed by chylous ascites and protein-losing gastroenteropathy. This association reported in only three cases in the literature leads us to discuss the relations between yellow nail syndrome, primitive intestinal lymphangiectasia and primary lymphatic disorders.

Aged↗
PubMedDate not supplied

[Neonatal jaundice due to anti-D allo-immunization with negative direct Coombs' test].

The case is reported of a newborn with jaundice due to anti-D Rh iso-immunization, with a negative Coombs' test. The finding of a positive red cell auto-agglutination test, the red cells being treated with bromelin and incubated in their own serum, suggests an immune phenomenon. Free antibody with anti-D specificity reacting with bromelin treated R.B.C.'s was found in the sera of the mother and infant.

Coombs Test↗
PubMedDate not supplied

[Acute lymphoblastic leukemia in children. The use of antisera specific for lymphocyte populations in a classification trial].

Mononuclear cells from 14 children with acute lymphoblastic leukaemia (ALL) were studied using several lymphocyte membrane markers: E-rosettes, "active" E-rosettes, surface immunoglobulins, EA-rosettes. The use of these techniques and of three specific heterologous antisera directed against T and B cell antigens enabled the discrimination of three different ALL types according to the stage of cell maturation at which it is likely that neoplastic differention occured: T-cell ALL, pre-thymic cell ALL, and "non-T non-B" cell ALL showing only HLA-DR antigens.

B-Lymphocytes↗
PubMedDate not supplied

[Male pseudohermaphroditism caused by partial insensitivity to androgens. Clinical and biochemical heterogeneity].

Male pseudohermaphroditism due to partial androgen insensitivity (PAI) may be suspected clinically in case of incomplete masculinization of external genitalia in spite of age related plasma androgen levels. In 25 children or adolescents in whom PAI was suspected, the 5 alpha-reductase activity of external genitalia fibroblasts, the number of androgen receptor sites (Bmax) and the affinity of receptors for dihydrotestosterone (Kd) were studied. Clinical expression of PAI is highly polymorphic (Prader's type I to type IV), when most children (18/25) were considered as males. In a single patient the very low 5 alpha-reductase activity permitted the diagnosis of 5 alpha-reductase deficiency. The number of receptor sites (fmoles/mg DNA) varied from 0 to 730. Mean Bmax of patients (282 +/- 187 fmoles/mg DNA) was statistically lower than that of normal subjects (642 +/- 220 fmoles/mg DNA), p less than 0.05. The 5 cases in whom receptor concentrations were normal may be related to a qualitative abnormality of the androgen receptor or to a "post-receptor" defect. On the contrary no significant differences in Kd values were found. Correlation between sexual ambiguity and the number of measured receptors was not possible. These results emphasize the clinical and biochemical heterogeneity of PAI. Nevertheless, the decrease in number of androgen receptor sites remains the major data for the biochemical diagnosis of PAI. Study of post-receptor "markers" (3 alpha-reductase activity, aromatase, collagen) might allow better analysis of cases with PAI in whom androgen receptor concentrations are normal.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗