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R Janković

Publications and source records attributed to R Janković.

14 recordsLinked to original sources
PubMed2001

Progesterone receptor status of breast cancer metastases.

PURPOSE: The usefulness of steroid receptor content in breast cancer metastases for metastatic disease therapy planning was examined in this study. METHODS: Steroid receptors in primary tumors and corresponding metastases in the same breast cancer patients ( n=23) were determined by five-point DCC assay. We carried out an analysis of the therapeutic response and comparison of the progression-free interval of patients treated with endocrine/chemo-endocrine therapy for metastatic disease according to the positive/negative progesterone receptor status of primary tumors, or of breast cancer metastases. RESULTS AND CONCLUSIONS: It seems that the lack of positive progesterone receptors in metastasis (0/8) and conversion from PR+ primary to PR- metastasis (5/8) may be important in describing the non-responder phenotype. We obtained a similar progression-free interval in patients with progesterone receptor-positive/negative primary tumors, but a longer progression-free interval in the patients with progesterone receptor-positive metastases ( n=9) than with negative ones ( n=14), indicating the possibility of using steroid receptor content from metastases for metastatic disease therapy planning.

Adult↗
PubMed2001

PS2 protein in breast carcinomas: cut-off value of estrogen-regulated expression.

This study includes 152 patients with histologically confirmed breast carcinoma. Steroid hormone receptors (SR), estrogen (ER) and progesteron (PR) receptors, and pS2 protein were assayed on the same cytosolic extract in accordance with the recommendation of EORTC. Our results showed menopausal- and histologic grade-related expression of pS2 protein. Unfavorable carcinoma subgroups, in relation to expression of pS2 protein were defined: postmenopausal carcinomas with histologic grade II, and pre-, as well as postmenopausal carcinomas with histologic grade III. There were overlappings of individual pS2 protein values between favorable and unfavorable carcinoma subgroups in relation to the expression of pS2 protein. Otherwise, no overlapping of pS2 protein values was obtained between ER-positive and ER-negative carcinomas within defined unfavorable menopausal - and histologic grade-related expression of pS2 protein subgroups. The highest pS2 protein level observed in ER-negative unfavorable subgroups (15 ng/mg) was considered as the cut-off value which defined estrogen-regulated expression of pS2 protein.

Adult↗
PubMed1992

Androgen-producing bilateral large cortical adrenal adenomas associated with polycystic ovaries in a young female.

An association of bilateral large adrenocortical androgen-producing adenomas with polycystic ovaries in a young female is presented. She developed mild hirsutism and secondary amenorrhoea at the age of 17, and was treated for 3 years with an anti-androgen (cyproterone acetate) and ethinyloestradiol. Routine follow-up at the age of 21 showed bilateral large adrenal tumours and polycystic ovaries, together with high serum testosterone and dehydroepiandrosterone sulphate values. Bilateral adrenalectomy was performed, which resulted in lowering of the elevated androgens, and large bilateral adrenocortical adenomas were confirmed histologically. Contrary to expectations, the polycystic appearance of the ovaries persisted after adrenalectomy. This case supports the possible role of adrenal androgens in the pathogenesis of polycystic ovaries as well as the possibility of the persistence of polycystic ovaries without adrenal androgens once they have developed.

Adenoma↗
PubMed1991

[Occurrence of thyroid gland carcinoma in Graves-Basedow disease].

Among 319 patients with Graves-Basedow disease who were operated upon in surgical department of The Institute of Endocrinology in Belgrade between 1978 and 1990, thyroid carcinoma was found in 15 cases (4.7%). In 10 patients carcinoma was suspected before operation because of the node in diffuse goiter, while in 5 patients carcinoma was found unexpectedly. Tumor was smaller than 1 sm in only one patient. Nine patients had papillary carcinoma, 4 had follicular and 2 had medullary carcinoma. One patient with medullary carcinoma had been treated previously with radioactive iodine. In 2 patients carcinoma was found in recurrent goiter after primary operation, patients with thyroid carcinoma in Graves-Basedow disease were averaging about 10 years older than other patients with Graves-Basedow disease treated surgically.

Adult↗
PubMed1986

Occult papillary carcinoma of the thyroid gland revealed by cancer pericarditis.

We report a case of hemorrhagic exudative pericarditis in a 41-year-old man which was found to be due to metastatic dissemination of a 4 mm sclerosing carcinoma of the thyroid. Many psammoma bodies were found in the pericardial specimens and malignant cells with folliculoid pattern were observed in the pleural biopsy, arousing suspicion of occult papillary thyroid carcinoma. In the thyroid gland after total thyroidectomy a 4 mm sclerosing carcinoma was found.

Adult↗
PubMedDate not supplied

pS2 in breast carcinoma: association with steroid hormone receptor status.

AIMS AND BACKGROUND: Knowledge of the steroid hormone receptors has proved to be of significant value in breast cancer. In the present study the possible importance of estrogen-regulated pS2 protein was investigated. Our direct purpose was to answer the question whether the expression of pS2 may be a marker of functional heterogeneity with respect to the steroid hormone receptor status. METHODS AND STUDY DESIGN: The study included 152 patients with primary, operable, histologically confirmed breast carcinomas. Histology specimens were reviewed and classified according to type, nodal status, tumor size and grade. Steroid hormone receptors were assayed by biochemical methods according to the procedures recommended by the EORTC. pS2 protein measurement was performed in breast carcinoma cytosols using an immunoradiometric assay. The results were analyzed by non-parametric statistical methods. RESULTS: A statistically significant inverse correlation between pS2 protein expression and histological tumor grade was found. The expression of pS2 protein was confirmed to be correlated with steroid hormone receptor status. However, it is important to point out that in spite of these statistically significant findings there were no significant biological associations due to overlapping individual pS2 protein values. The baseline level of expression of pS2 protein was obtained in histological grade III carcinomas with a negative steroid hormone receptor status. It was shown that the distribution of carcinomas according to the baseline level of pS2 protein expression was heterogeneous among estrogen receptor-positive carcinomas, and strikingly homogeneous among estrogen and progesterone-negative carcinoma. CONCLUSION: Our study suggested that PR and pS2 protein may identify distinct subsets of estrogen receptor-positive breast carcinomas.

Breast Neoplasms↗
PubMedDate not supplied

[Desmoid tumors].

Explore the source record for details and available documents.

Abdominal Muscles↗
PubMedDate not supplied

[Immunohistochemical analysis of malignant tumors of the thyroid gland using 6 relevant markers].

The results of immunohistochemical study of malignant thyroid tumours using six markers-thyroglobulin (TGB), keratin, carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), calcitonin and leucocyte common antigen (LCA)-are presented. Thirty-three cases of thyroid carcinomas were studied: 11 papillary, 8 follicular, 7 medullary and 7 anaplastic carcinomas. All cases of papillary and follicular tumours showed positive reaction with TGB and 4 papillary and 3 follicular carcinomas reacted with CEA also. 100% reactivity with calcitonin and CEA were observed in the medullary carcinoma group, while anaplastic carcinomas revealed TGB (one case), CEA (two) and EMA (three) reactivity. None of the studied tumours responded to LCA. TGB and calcitonin proved to be useful in distinguishing tumours originating in follicular cells from those originating in parafollicular cells and, along with LCA, enabled discrimination of anaplastic carcinomas from medullary carcinomas and malignant lymphomas. CEA can be only used as an auxiliary marker in cases of medullary carcinoma, while EMA and high molecular weight keratins did not prove to be reliable markers for analysis of malignant thyroid tumours.

Biomarkers, Tumor↗
PubMedDate not supplied

[Anaplastic carcinomas of the thyroid gland].

Anaplastic carcinoma of the thyroid gland is a tumor of great malignant potential. The majority of the patients die in the period of 6-24 months after diagnosis is made. A review of 90 cases of anaplastic carcinoma of the thyroid gland surgically treated in the Department for Endocrine Surgery of The Second Surgical Clinic and Center for Endocrine Surgery of the Clinical Centre of Serbia revealed that anaplastic carcinomas were 11.3% of all the thyroid carcinomas (796) diagnosed in the cited period. The patient's age varied from 40 to 80 (mean 63.7 years). The incidence in women is twice as large as in men (2.1:1). Intraoperative histopathologic diagnosis was made in all the patients. The variations in histological structure were noticed. Dominant histopathologic features included pleomorphic giant and spindle cells, with irregular hyperchromatic nuclei and many aberrant mitotic figures with necrosis and infiltration of blood vessels by neoplastic tissue in most of the cases.

Adult↗