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Biomedical subjects

R Jaffe

Publications and source records attributed to R Jaffe.

At least 289 records · Page 16Linked to original sources

Functional outcome comparison of semiconstrained and unconstrained total elbow arthroplasties.

Twenty-six patients, each of whom had undergone either a semiconstrained (linked) or an unconstrained (unlinked) total elbow arthroplasty, were examined specifically to evaluate the restoration of function with respect to activities of daily living. The functional outcomes of these 2 groups were then compared to identify any significant differences. All of the unlinked/unconstrained prostheses were Ewald total elbow arthroplasties; the linked/semiconstrained prostheses, all of which were performed by a single surgeon, were Mayo-Coonrad prostheses. Follow-up radiographs, taken to rule out loosening or failure of the prosthesis as a cause for functional deficits, were available for review for 25 elbows. There were 14 elbows in 13 patients who had semiconstrained prostheses and 12 elbows in 10 patients who had unconstrained total prostheses. Average age at the time of elbow replacement surgery was 62.8 years (range, 47-75 years) for the semiconstrained group and 63.1 years (range, 54-74 years) for the unconstrained group. The semiconstrained group consisted of 8 female and 6 male elbows; the unconstrained group consisted of 10 female and 2 male elbows. Follow-up averaged 35.5 months (range, 24-73 months) in the semiconstrained group and 73 months (range, 27-110 months) in the unconstrained group. Twenty-two operations were performed for rheumatoid arthritis, 3 for posttraumatic humeral nonunion, and 1 for posttraumatic degenerative arthritis. Two elbows required revision, one (in the semiconstrained group) for aseptic loosening and the other (in the unconstrained group) for metal synovitis and pain from a chronically dislocated prosthesis; both of these elbows were considered failures and excluded from the functional comparison. No significant differences in functional performance were found, and no elbows demonstrated progressive radiolucencies suggestive of loosening. With the exception of 1 patient (in addition to the patients who had revisions) with a dislocated unconstrained prosthesis, all patients were satisfied with the procedure. It appears that when it is properly performed, total elbow arthroplasty with either type of prosthesis yields satisfactory functional results.

Activities of Daily Living↗

Changes in uterine artery doppler velocimetry in pregnant patients undergoing glucose tolerance test may predict adverse outcome in later pregnancy: a preliminary study.

OBJECTIVE: Previous studies have demonstrated that high glucose levels often cause increased placental resistance to blood flow. The present study was undertaken to assess whether any changes in placental vascular resistance would occur following a standard glucose tolerance test. METHODS: Doppler velocimetry of uterine, intraplacental and umbilical vessels was performed before and after administration of glucose tolerance test. RESULTS: The uterine circulation demonstrated abnormal indices in patients that later developed placental insufficiency. CONCLUSION: This preliminary study demonstrated that following a glucose tolerance test significant changes seem to occur in the uteroplacental but not in the fetoplacental circulation of pregnancies destined to develop preeclampsia or intrauterine growth restriction.

Arteries↗

Significance of echogenic foci in the left ventricle of the fetal heart in a low-risk population.

OBJECTIVE: To determine if there exists a significant association between prenatally detected left ventricular echogenic foci and chromosomal abnormalities. METHODS: Over a 10-month period the presence of intracardiac echogenic foci was recorded on all low-risk patients referred for anatomical assessment. The study group consisted of 113 singleton fetuses and was compared to a control group with no foci. RESULTS: Among the study group with echogenic foci, 5 chromosomal abnormalities (three trisomies) were detected. In the control group only one chromosomal abnormality was diagnosed. CONCLUSION: An association exists between the finding of intracardiac echogenic foci in the fetus and the presence of chromosomal abnormalities.

Adult↗

Multiple cardiac rhabdomyomas detected in utero.

Prenatal fetal echocardiography studies detected large multiple cardiac rhabdomyomas and led to the diagnosis of tuberous sclerosis. Despite episodes of bradyarrhythmias and severe lung compression in utero, the neonate did well and was discharged home on day 20 of life. On day 30 of life, the infant expired at home from cardiac arrest secondary to arrhythmia.

Adult↗

Relationship between pretreatment electroencephalographic coherence measures and subsequent response to electroconvulsive therapy: a preliminary study.

Quantitative analyses of EEG recordings taken prior to a course of ECT in elderly depressed patients showed that normal anterior interhemispheric coherence in the delta frequency band was associated with more favorable clinical response to ECT, whereas lower coherence values were associated with incomplete therapeutic response. Clinical implications of these findings are discussed.

Aged↗

Cryotherapy in ankle sprains.

This study assesses recovery from ankle sprains. Thirty-seven final participants were categorized according to the severity of their injury and the use of cryotherapy (15 minutes, one to three times per day) versus heat therapy (15 minutes, one to three times per day) for a minimum of three days. Therapy commenced either less than one hour, from one to 36 hours, or greater than 36 hours after traumatic event. Sprains were graded into five categories based on severity of the injury, but only two categories, subject to conservative treatment, are considered in this study. The study showed that cryotherapy started within 36 hours after the injury was statistically more effective than heat therapy for complete and rapid recovery. Patients in a group with Grade four sprains (unable to bear weight because of pain) reached full activity in 13.2 days compared to 30.4 days in a group using cryotherapy initiated 36 hours after injury or to 33.3 days in a group using heat therapy. Therefore, early use of cryotherapy, continued with adhesive compression, is an effective treatment of ankle sprains yielding earlier complete recovery than late cryotherapy or heat therapy.

Adolescent↗

Adverse interaction between clonidine and verapamil.

OBJECTIVE: To report two cases of a possible adverse interaction between clonidine and verapamil resulting in atrioventricular (AV) block in both patients and severe hypotension in one patient. CASE SUMMARIES: A 54-year-old woman with hyperaldosteronism was treated with verapamil 480 mg/d and spironolactone 100 mg/d. After the addition of a minimal dose of clonidine (0.15 mg bid), she developed complete AV block and severe hypotension, which resolved upon cessation of all medications. A 65-year-old woman was treated with extended-release verapamil 240 mg/d. After the addition of clonidine 0.15 mg bid she developed complete AV block, which resolved after all therapy was stopped. DISCUSSION: An adverse interaction between clonidine and verapamil has not been reported previously. We describe two such cases and discuss the various mechanisms that might cause such an interaction. Clinicians should be acquainted with this possibly fatal interaction between two commonly used antihypertensive drugs. CONCLUSIONS: Caution is recommended in combining clonidine and verapamil therapy, even in patients who do not have sinus or AV node dysfunction. The two drugs may act synergistically on both the AV node and the peripheral circulation.

Aged↗

Pancreatic pathology in trisomy 13: specificity of the morphologic lesion.

Pancreases from 8 patients with trisomy 13 were studied. Ectopic splenic tissue was present in 6: 3 had accessory spleens and ectopic splenic tissue embedded in the pancreas, one had intrapancreatic splenic tissue without an accessory spleen, and one had an accessory spleen without intrapancreatic splenic tissue. The intrapancreatic splenic tissue was multiple, generally poorly or nonencapsulated, and contained pancreatic acini, islets of Langerhans, and ducts lined by tall columnar epithelium with goblet cells. The rest of the pancreas in these and other cases of trisomy 13 had microcyst formation and focal proliferations of small ducts similar to those seen in the splenic tissue. This constellation of features appears to be distinctive of trisomy 13.

Abnormalities, Multiple↗

Congenital Budd-Chiari syndrome.

Budd-Chiari syndrome, due to thrombotic occlusion of hepatic veins or ostia, is unusual in infants. Review of the literature reveals no documented case symptomatic at birth. We describe a male infant with ascites present at birth. A liver biopsy at 7 weeks of age showed sinusoidal dilatation, but the diagnosis of Budd-Chiari syndrome was made only at autopsy, 4 months later. The cause was not determined although maternal drug abuse was suspected.

Ascites↗

Review of human dendritic cells: isolation and culture from precursors.

There is no single characteristic or marker that identifies a dendritic cell. This review of the methods used for dendritic cell identification stresses that changes occur over the lifetime and changing functional status of the cell. Human dendritic cell populations have been obtained from adult peripheral blood, umbilical cord blood, bone marrow, thymus, and monocytes as starting substrates. Most recently dendritic cell populations have been grown from separated hematopoietic precursors, suggesting that there is a common granulocyte-monocyte-dendritic cell progenitor. Whether monocytes and dendritic cells can be modulated back and forth remains an open question. Granulocyte-monocyte colony stimulating factor (GM-CSF) appears to be critical to the development and function of these enriched and cultured cells. The characteristics of the cells produced by these various methods are tabulated. Important to the understanding of Langerhans cell biology is the variation in CD1 expression under different circumstances.

Adult↗

Hypothesis: pathogenesis of skip areas in long-segment Hirschsprung's disease.

The existence of skip areas in a subset of patients with long-segment Hirschsprung's disease (LSHD) is a rare phenomenon that poses practical and theoretical challenges. In this paper, three new cases are described and compared with preceding reports in the medical literature. In addition, an analogous distribution of ganglion cell precursors is reported in the developing large intestines of murine embryos, homozygous for the lethal spotted (ls) allele. In ls/ls embryos, which were destined to have "classic" short-segment aganglionosis coli, a transient phase was observed in which ganglion cells were present in the middle colon, but absent from the cecum and distal large intestine. This "skip area" is attributed to an extramural phase of neuroblast migration which is unique to the colon. Persistence of an abnormal pattern of neuroblast migration, similar to that observed transiently in ls/ls embryos, is invoked as an explanation for skip areas in humans with LSHD.

Animals↗