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Biomedical subjects

R J Yu

Publications and source records attributed to R J Yu.

At least 37 records · Page 2Linked to original sources
PubMed1984

Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids.

Hyperkeratinization is a primary or fundamental event in a majority of today's skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesion is determined by strength of intercellular bonding. Intercellular bonding is weakened by water and diminished by retinoids and alpha hydroxy acids (AHAs). Conversely, bonding is strengthened or enhanced by dehydration, vitamin A deficiency, and some alpha acetoxy acids (AAAs). Agents that control or modify keratinization can be useful in treatment of many skin disorders.

Animals↗
PubMed1971

Pigment production of Cryptococcus neoformans grown with extracts of Guizotia abyssinica.

Brown pigment(s) formed in Cryptococcus neoformans when grown on media containing extracts of the seeds of Guizotia abyssinica cannot be extracted by common organic solvents or by 6 n HCl or 2 n NaOH. A similar pigmentation was observed in C. neoformans when grown on a medium containing caffeic acid isolated from the hydrolyzed methanol extract of G. abyssinica seeds. Its methyl ester and the diacetate thereof, as well as the following structurally related compounds, 3-hydroxytyramine, 3,4-dihydroxybenzoic acid, 3,4-dihydroxyphenylethanolamine, and 4-hydroxy-3,5-dimethoxycinnamic acid, brought about similar pigmentation. However, 2,4-, 2,5-, 2,6-, and 3,5-dihydroxybenzoic acids, tyrosine, phenylalanine, cinnamic acid, 4-hydroxycinnamic acid, and 4-hydroxy-3-methoxycinnamic acid did not cause coloration in C. neoformans.

Cinnamates↗