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Biomedical subjects

R J Siegle

Publications and source records attributed to R J Siegle.

At least 37 records · Page 2Linked to original sources
PubMed1989

Multidisciplinary surgical approach to the treatment of perinasal nonmelanoma skin cancer.

A subgroup of midfacial basal and squamous cell carcinomas invade extensively into the surrounding soft tissues and at times into bone, cartilage, and the nearby cavities. Their management can be optimized by using the combined skills of the Mohs micrographic surgeon and the head and neck surgeon. Relevant tumor biology and anatomy of this area are presented as a background for the discussion of the mechanics involved in tumor extirpation. Reconstructive philosophies and alternatives are reviewed.

Basal Cell Carcinoma↗
PubMed1988

Verrucous carcinoma arising in ulcerative lichen planus of the soles.

Verrucous carcinoma is a low-grade squamous cell carcinoma. Chronic inflammation is an important factor in its pathogenesis. This is the first case of plantar verrucous carcinoma arising in a lesion of ulcerative lichen planus. This paper also lends further support to the successful use of Mohs micrographic surgical technique as the treatment of choice for verrucous carcinoma.

Aged↗
PubMed1988

Transplantation of human basal cell carcinoma to C57/BALB/C bgJ/bgJ-nu/nu (beige-nude) mouse.

The purpose of this study was to evaluate the transplantation of BCC to the C57/BALB/C bgJ/bgJ-nu/nu (beige-nude) mouse. This animal has two gene defects which are expressed as impairment of natural killer cells (NK cells) as well as the absence of a thymus. The results demonstrate that human BCC can be successfully transplanted to the C57 beige-nude mouse without the need for supplemental immunosuppression. It may be that the impairment of NK cell activity in the beige-nude mouse model plays a significant role in tumor transplantation.

Animals↗
PubMed1987

Immune responses to bovine collagen implants. Significance of pretreatment serology.

Bovine collagen implants are in widespread use for the correction of soft tissue deficiencies. A small portion of the population responds adversely to these implants, evidenced by either positive skin tests or treatment site reactions. Antibodies against bovine collagen implants have been detected in the sera of virtually all patients with adverse treatment reactions and in small percentages of untreated individuals and treated individuals without adverse reactions. In this study we examined the levels of anti-bovine collagen implant antibodies in 150 individuals prior to bovine collagen implant therapy and then monitored these patients for adverse reactions to skin tests and bovine collagen implant treatments. Statistical analyses were performed to determine the value of pretreatment serology in predicting positive skin tests or adverse reactions. It was determined that individuals with greatly elevated levels (greater than 2 standard deviations [SDs] above the mean reactivity of pretreatment sera) of anti-bovine collagen implant antibodies prior to treatment were approximately sixfold more likely to suffer adverse reactions than patients with no elevation of antibodies prior to treatment.

Animals↗
PubMed1987

Iododerma occurring after orally administered iopanoic acid.

A 45-year-old man with multiple myeloma developed iododerma after oral cholecystography with iopanoic acid. The lesions appeared two days after two exposures to iopanoic acid given within one week. To our knowledge, this is the first reported case of iododerma in association with multiple myeloma and orally ingested radiocontrast dye.

Administration, Oral↗
PubMed1986

Effects of topical clindamycin on intestinal microflora in patients with acne.

Thirty-two patients with acne completed a randomized, double-blind study using topical 1% clindamycin phosphate or its vehicle applied twice daily for 8 weeks for a study of its effects on the intestinal microflora. Two clindamycin patients and one vehicle patient had Clostridium difficile in stools prior to therapy. Of the remaining twenty-nine patients, four of nineteen patients who used clindamycin and none of ten patients who used vehicle had C. difficile detected during treatment; the difference was not statistically significant. There was no diarrhea in the clindamycin group, even though clostridial cytotoxin was found transiently in two patients. Self-limited diarrhea occurred in one vehicle-treated patient, whose stool culture was negative but whose stool specimen showed a positive reaction for C. difficile cytotoxin. With the use of a bioassay, clindamycin was not detected in urine or stool of any patient. No significant changes in Bacteroides fragilis counts in stools were observed in either group.

Acne Vulgaris↗
PubMed1986

The biology of basal cell carcinomas--a revisit and recent developments.

This paper will review some of the present information on the biology of basal cell carcinoma. Recent developments include a better understanding of the basement membrane components surrounding the tumor nodules, as well as identifying the most actively dividing cells in solid basal cell carcinoma by autoradiographic techniques. The implications of a recently developed animal model will also be discussed.

Animals↗
PubMed1986

Infiltrative basal cell carcinoma: a nonsclerosing subtype.

Infiltrative basal cell carcinoma is a distinct histologic subtype of basal cell carcinoma (BCC). Criteria for its diagnosis are presented and its nonsclerotic nature emphasized. Analysis of 174 consecutive BCCs referred for Mohs micrographic surgery showed the infiltrative subtype (29 tumors) to be significantly more destructive and difficult to treat than the more common nodular BCC.

Basal Cell Carcinoma↗
PubMed1986

Treatment of chromomycosis with a CO2 laser.

The successful employment of a carbon dioxide (CO2) laser in the eradication of localized chromomycosis is described. A review of alternative medical and surgical modalities used in treating this disorder is presented. The potential benefits of CO2 laser vs. cold steel surgery are discussed.

Aged↗
PubMed1985

Characterization of the humoral immune response to bovine collagen implants.

The use of bovine collagen implants (BCIs) for the correction of dermal contour deformities is becoming widespread. A small percentage of patients receiving treatment with BCIs suffer adverse reactions that appear to be of an immune nature. Circulating antibodies to BCIs are found in all patients suffering adverse treatment reactions and in small numbers of normal individuals and BCI-treated patients not suffering adverse reactions. These antibodies are always IgG, although quite often IgA is also present. The anti-BCI antibodies are quite stable, suffering virtually no loss of activity after storage at room temperature for 54 days. Immunoblotting studies indicate that no singular component of the BCI collagen is the prime antigenic component; multiple regions of the collagen molecule are recognized by patients' antibodies.

Animals↗
PubMed1984

Cutaneous candidosis as a complication of facial dermabrasion.

Cutaneous candidosis is a common skin condition. Facial candidosis is rare. Described herein are three cases of facial candidosis complicating dermabrasion, a previously undescribed condition. Why this may occur, why it is uncommon, and its differential diagnosis and therapy are discussed. The side effects and complications of dermabrasion in general are presented.

Adult↗
PubMed1984

Dapsone-induced peripheral neuropathy. Case report and review.

A severe motor and a minor sensory neuropathy developed in a man being treated with dapsone (4,4'-diaminodiphenylsulfone) for dermatitis herpetiformis. He had received dapsone for 16 years before any signs of neurotoxicity became evident. Electrodiagnostic and clinical features were consistent with an axonal neuropathy. Clinical characteristics of dapsone-induced neuropathy include a motor neuropathy affecting the extremities, usual onset within five years after the initiation of dapsone therapy, dapsone dosage usually equal to or greater than 300 mg/day, and, almost always, complete recovery from the neuropathy after dapsone-dose reduction or withdrawal. The patient was found to be a slow acetylator of sulfamethazine, and therefore is a slow acetylator of dapsone. An HLA typing was done on the patient. New cases of dapsone-induced neuropathy should be HLA typed and have acetylation profiles in an attempt to identify future high-risk patients. This case is noteworthy for the length of time of dapsone usage (16 years) and the low daily dosage of dapsone (100 mg) taken prior to the development of neuropathy.

Adult↗
PubMed1984

Intradermal implantation of bovine collagen. Humoral immune responses associated with clinical reactions.

A special collagen implant (Zyderm) (ZCI) is a biomaterial used for the correction of dermal contour deformities. Although infrequent, reactions believed to be of an immunologic nature have followed treatment. To investigate whether humoral immunity is associated with these reactions, we studied 40 patients for the presence of anti-ZCI antibodies using an enzyme-linked immunosorbent assay. Ten patients who had had adverse treatment reactions uniformly exhibited circulating anti-ZCI antibodies. Twenty-nine of 30 control patients, including nine who had received ZCI without adverse reaction, failed to produce the high levels of antibodies found in all clinical reactors. This difference was statistically significant. Additional investigations confirmed that the antibodies studied were directed primarily against the bovine collagen component of the ZCI. These data suggest that the humoral immune system is capable of recognizing ZCI and that the presence of antibodies to the ZCI correlates with the occurrence of adverse reactions.

Adult↗
PubMed1984

Phenol alcohol technique for permanent matricectomy.

A simple technique for partial or complete destruction of the nail matrix with the use of phenol alcohol is outlined. A retrospective analysis of 30 random patients suggests that it has a low morbidity, is easy to perform, and has a high success rate. Therefore, it offers an excellent option to cold steel surgery, especially for the nonsurgically oriented dermatologist.

Administration, Topical↗
PubMed1983

Treatment site reactions to Zyderm Collagen Implantation.

Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti-Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction.

Acne Vulgaris↗