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Biomedical subjects

R J Pye

Publications and source records attributed to R J Pye.

36 records · Page 2Linked to original sources
PubMed1983

Seborrhoea is not a feature of seborrhoeic dermatitis.

The sebum excretion rate from forehead skin was measured in 44 patients with classic seborrhoeic dermatitis and 200 control subjects. The mean excretion rate was normal in the 29 men with seborrhoeic dermatitis and significantly reduced in the 15 women with the disease. This study showed that seborrhoeic dermatitis is not usually associated with seborrhoea, and therefore "dermatitis of the sebaceous areas" may be a more accurate term.

Adolescent↗
PubMed1979

Erosive pustular dermatosis of the scalp.

We report six patients with a previously undescribed but characteristic pustular dermatosis confined to the scalp. All the patients were elderly women who developed chronic, extensive, pustular, crusted and occasionally eroded lesions of the scalp which produced scarring alopecia. Investigations were essentially negative and skin biopsies showed only non-specific changes of atrophy and chronic inflammation, sometimes with increased plasma cells in the infiltrate. The condition did not respond to antibiotics, but was suppressed by potent topical steroids.

Aged↗
PubMed1977

Effect of oral contraceptives on sebum excretion rate.

Oral contraceptives containing a high dose of oestrogen reduce the sebum excretion rate (SER) and improve acne vulgaris, but more progestogenic preparations may exacerbate acne. The effect on the SER of several oral contraceptives with varying progestogenic potencies was studied in 81 women. The predominantly progestogenic pills (Eugynon 30, Gynovlar) produced no significant change in SER, whereas the rate in women taking a more oestrogenic pill (Minovlar) was significantly reduced compared with the rate in controls. Progestogens therefore do not exacerbate acne by inducing seborrhoea, but in the doses we studied they nullified the inhibitory effect of oestrogens on the sebaceous glands. Acne-prone women who require an oral contraceptive should be given a predominantly oestrogenic preparation.

Acne Vulgaris↗
PubMed1976

Treatment of rosacea by metronidazole.

A double-blind trial in twenty-nine patients with rosacea showed that, after 6 weeks' treatment, metronidazole was therapeutically superior to a placebo (P less than 0-02). It was particularly effective against papules and pustules. The mode of action of metronidazole and other antibiotics in rosacea is not known.

Administration, Oral↗
PubMed1976

Skin surface lipid composition in rosacea.

Skin surface lipid composition was measured in thirty-one patients with rosacea and their age-matched controls. Patients with rosacea had normal lipid composition, and there was no correlation between the lipid composition and the severity of the disease. Tetracycline therapy produced no measurable change in lipid composition.

Adult↗
PubMed1976

The treatment of psoriatic nail dystrophy with intradermal steroid injections.

Thirty-seven patients with psoriatic nail dystrophy were treated with intradermal nail-fold injections of either triamcinolone acetonide or triamcinolone hexacetonide, using the Port-O-Jet needleless injector. Mild nail-matrix changes showed a very good response to treatment, whilst nail-bed and/or hyponychial changes causing onycholysis and the more severe types of dystrophy usually showed little improvement. Although in occasional cases this may be a useful form of treatment, we would not recommend its general use in patients with psoriatic nail dystrophy.

Female↗
PubMed1976

Contact dermatitis due to Nyloprint.

The Nyloprint process is becoming more frequently used in Great Britain. We report a case of contact dermatitis in a 60-year-old man who was employed in the production of Nyloprint formes. The process is described in detail. Patch tests showed him to be very sensitive to an acrylamide derivative, which is used as a monomer in this process.

Acrylamides↗
PubMed1975

The sebum excretion rate in rosacea.

The sebum excretion rate (SER) was measured in fifty-five patients with rosacea and 126 control subjects. The mean SER in the patients with rosacea was not increased, nor was there any correlation between SER and severity of rosacea. Our data suggest that seborrhoea plays no part in the pathogenesis of rosacea.

Adult↗