Mutagenesis in Escherichia coli. II. Evidence for a common pathway for mutagenesis by ultraviolet light, ionizing radiation and thymine deprivation.
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DNA, Bacterial↗
Biomedical subjects
R J Munson
Publications and source records attributed to R J Munson.
Ultraviolet and gamma-ray mutagenesis in E. col: is there a common mechanism?
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DNA Replication↗
On the nature of the lethal and mutagenic action of ultraviolet light on frozen bacteria.
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Bacteria↗
Radiosensitization by N-ethylmaleimide: observations with sensitive and resistant strains of Escherichia coli.
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DNA, Bacterial↗
The sensitivity of Escherichia coli to ionizing particles of different LETs.
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Alpha Particles↗
Differential induction and repair of ultraviolet damage leading to true revesions and external suppressor mutations of an ochre codon in Escherichia coli B-r WP2.
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Coliphages↗
Site of lethal damage by ionizing radiation in Escherichia coli B-r growing exponentially in minimal medium.
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Chromosomes↗
Excision-repair of DNA damage in an auxotrophic strain of Escherichia coli.
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DNA, Bacterial↗
Ultraviolet damage to bacteria and bacteriophage at low temperatures.
The survival of Escherichia coli B/r WP2 (tryptophan-requiring) from ultraviolet irradiation when suspended in 0.067M phosphate buffer (pH 7) has been studied over the temperature range 22 degrees to -269 degrees C. In unfrozen suspensions there was no appreciable change in sensitivity between 22 degrees and -10 degrees C. The sensitivity in the presence of ice progressively increased by a factor of 7 when the temperature was lowered to -79 degrees C. Between -79 degrees and -196 degrees C the sensitivity decreased to less than four times the sensitivity at 22 degrees C and was not appreciably different at -269 degrees C. Evidence from experiments with bacteriophage T1 and E. coli WP2 HCR(-) (a strain unable to excise thymine dimers) indicates that a new, qualitatively different lesion, less amenable to repair, may replace the thymine dimer in E. coli irradiated at -79 degrees C.
Cold Temperature↗
Mutation in Escherichia coli B/r WP2 try by reversion or suppression of a chain-terminating codon.
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Coliphages↗
Noninvasive CT determination of arterial blood concentration of meglumine iothalamate.
A quantity that often must be determined in physiological imaging studies is the blood concentration of the tracer over time. This is usually performed by direct arterial or venous blood sampling. We studied the relationship between the concentration of meglumine iothalamate in arterial blood and values determined from voxels containing large blood vessels in a series of CT images at the same location over time. After correction for volume averaging based on a single venous blood sample, there was an excellent correlation between the two blood curves. Differences between the curves were shown to be inconsequential by a simulation of transcapillary transport determinations. We thus conclude that determination of plasma concentration from CT images is a reliable technique for CT transcapillary transport studies.
Animals↗