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Biomedical subjects

R J Meech

Publications and source records attributed to R J Meech.

15 recordsLinked to original sources
PubMed1991

AIDS and surgeons.

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AIDS Serodiagnosis↗
PubMed1985

Non-specific vaginitis: diagnostic features and response to imidazole therapy (metronidazole, ornidazole).

Detailed quantitative aerobic, anaerobic, fungal and mycoplasma flora was obtained for 43 women presenting with complaints of vaginal discharge and malodour. Clinical response was associated with eradication of the abnormal anaerobic flora, despite persistence of G vaginalis in nine (26%). Topical imidazole therapy appeared to have some advantage over oral therapy. Gram stains of vaginal swabs were found to be the most useful laboratory investigation.

Administration, Oral↗
PubMed1985

Pathogenic mechanisms in recurrent genital candidosis in women.

A detailed analysis of the microbiological flora and investigation of the host immune response to Candida albicans was performed on 22 women presenting with a history of recurrent genital candidosis, as defined by at least four clinical episodes, with at least two episodes microbiologically proven, due to C albicans in the preceding 12 months. Disease due to C albicans could occur at low counts (10(2)-10(3)/ml) or very high counts (greater than 10(8)/ml). Immunological investigations indicated that both hypersensitive and anergic states occur, the nature of the host response determining the clinical features noted on presentation. Polymicrobial mixed infections were also noted in six women. Recognition of the nature of the host response is important in understanding the pathogensis of recurrent candidosis and devising effective therapeutic regimes.

Adult↗
PubMed1983

Candidosis.

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Antifungal Agents↗
PubMed1982

Tetracycline and minocycline in the management of non-gonococcal urethritis: a comparison.

A clinical trial compared the relative efficacy of tetracycline hydrochloride 250 mg qid and minocycline hydrochloride 100 mg bid given for an initial period of ten days to 59 patients suffering from non-gonococcal urethritis (NGU). Those patients with persistent symptoms or signs on completion of the initial course were given a second course for a further ten days at the same dosage. The treatments were equivalent. A significant number of patients not clinically cured after one course of treatment responded satisfactorily to a second course.

Adolescent↗
PubMed1982

Polymicrobial nature of vaginitis in young women: a microbiological and therapeutic study.

Thirty-six young females attending the Student Health Service with vaginitis were investigated by serial semiquantitative aerobic, anaerobic, fungal, mycoplasma and viral cultures over a 10 day period and results were correlated with signs and symptoms. Antifungal therapy (econazole pessaries and cream) resulted in clearance of candida from 13 out of 16 patients where there was no increase in the anaerobic flora. In the four subjects where candida was isolated along with Gardnerella vaginalis plus abnormal anaerobic flora, only one cleared with econazole, the remaining three clearing during therapy with metronidazole. In the nine subjects with Gardnerella vaginalis and abnormal anaerobic flora, metronidazole relieved symptoms despite failure to eradicate G. vaginalis in seven indicating the pathogenic role of the anaerobic flora rather then G. vaginalis. Mycoplasma hominis, Ureaplasma urealyticum and gram negative enteric bacilli were not implicated as primary agents in causing vaginitis.

Adolescent↗