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Biomedical subjects

R J Markert

Publications and source records attributed to R J Markert.

At least 19 recordsLinked to original sources

Development and transferability of a cost-effective laparoscopic camera navigation simulator.

BACKGROUND: Laparoscopic camera navigation (LCN) is vital for the successful performance of laparoscopic operations, yet little time is spent on training. This study aimed to develop an inexpensive LCN simulator, to design a structured curriculum, and to determine the transferability of skills acquired. METHODS: In this study, 0 degrees and 30 degrees LCN simulators were developed for use on a videotrainer platform. Transferability was tested by enrolling 20 medical students in an institutional review board-approved, randomized, controlled, blinded protocol. Subjects viewed a video tutorial and were pretested in LCN on a porcine Nissen model. Procedures were videotaped and the LCN performance was scored by a blinded rater according to the number of standardized verbal cues required and the percentage of time an optimal surgical view (%OSV) was obtained. Procedure time also was recorded. Subjects were stratified and randomized. The trained group practiced on the LCN simulator until competency was demonstrated. The control group received no training. Both groups were posttested on the porcine Nissen model. RESULTS: The constructed simulators required 35 man hours for development, cost $25 per board for materials, and proved to be durable. The trained group demonstrated significant improvement in verbal cues (p = 0.001), %OSV (p < 0.001), and procedure time (p = 0.001), whereas the control group showed improvement only in verbal cues (p < 0.02). At posttesting, the training group demonstrated significantly better scores for verbal cues (2.1 vs 8.0; p = 0.02) and %OSV (64% vs 45% p = 0.01) than the control group. CONCLUSION: These data suggest that the LCN simulator is cost effective and provides trainees with skills that translate to the operating room.

Adult↗

Length of esophageal cancer and degree of luminal stenosis during upper endoscopy predict T stage by endoscopic ultrasound.

BACKGROUND AND STUDY AIMS: Endoscopic ultrasonography (EUS) is considered to be the most accurate modality for T staging of esophageal cancer. This study attempted to determine whether endoscopic features such as the length and degree of luminal stenosis in esophageal cancer can predict the T stage on EUS. PATIENTS AND METHODS: Thirty-five patients with newly diagnosed esophageal adenocarcinoma or squamous-cell carcinoma undergoing EUS prior to initiation of any treatment were included in the study. The length of the tumor was assessed prospectively during esophagogastroduodenoscopy (EGD) before EUS in 22 patients. Radial EUS was then performed in these patients. The other 13 patients had sufficient luminal stenosis to prevent complete advancement of the echo endoscope through the tumor. In these 13 patients, the length of the esophageal cancer was not examined, but the T and N stage up to the level of maximum advancement of the echo endoscope through the tumor were noted. RESULTS: All 13 patients with luminal stenosis had at least a T3 (n = 12) or T4 (n = 1) lesion up to the level of maximum advancement of the echo endoscope. Among the 22 patients in whom the length of the esophageal cancer was measured, the mean length in the 13 patients with a T1 or T2 lesion on EUS was 2.6 cm. The mean length in the nine patients with T3 esophageal cancer was 7.1 cm. The difference in the mean length of T1 or T2 lesions (2.6 cm) was significantly different ( P < 0.001) from the mean length of T3 lesions (7.1 cm). Using a clinical diagnostic testing approach, when > or = 5 cm length was used as a criteria for diagnosing T3 lesions, the sensitivity was 89 %, specificity 92 %, positive predictive value 89 %, and negative predictive value 92 %. There was also a suggestion of increased chances of lymph-node metastases with increasing length of esophageal cancer. CONCLUSIONS: In esophageal carcinoma, endoscopic features such as the length of the cancer and the degree of luminal stenosis correlate with T staging on EUS. Esophageal cancers that are > or = 5 cm in length, or are sufficiently stenotic to prevent passage of an endoscope, are much more likely to be T3 or higher-stage lesions, while those that are < 5 cm in length have a greater chance (92 %) of being T1 or T2.

Adenocarcinoma↗

Stress, negative social exchange, and health symptoms in university students.

Although social support has been studied extensively in terms of its role in the relationship between stress and health, less attention has been devoted to the impact of negative social interactions. In this investigation, the authors examined the unique contributions of positive social support and negative social exchange in the relationship between stress and health symptoms, using data from 206 undergraduates at a large state university. Negative social exchange accounted for more variance in physical health symptoms than did life-event stress, daily hassles, or social support. The relationship between negative social interaction and physical symptoms was not the result of variance shared with psychological well-being. The importance of attending to negative aspects of social interaction among university students in terms of their health and well-being is discussed.

Adolescent↗

Social implications of blepharoptosis and dermatochalasis.

PURPOSE: To investigate the social implications of blepharoptosis and dermatochalasis. METHODS: Two hundred ten individuals rated whole-face photographs of a series of patients based on 11 different personal characteristics: intelligence, threat, friendliness, health, trustworthiness, hard work, mental illness, financial success, attractiveness, alcoholism, and happiness. Preoperative and postoperative photographs of both male and female patients with bilateral blepharoptosis and/or dematochalasis were used. The paired t test was used to compare preoperative versus postoperative ratings on the 11 characteristics. RESULTS: The preoperative photographs were rated more negatively than were the postoperative photographs (p < 0.01) on all 11 characteristics for both male and female patients by the 210 study subjects. CONCLUSIONS: Members of our society view individuals with blepharoptosis and dermatochalasis negatively. These social attitudes may lead to unjust bias toward affected patients, and surgical correction probably provides benefits beyond improved visual function.

Adolescent↗

Psychosocial implications of blepharoptosis and dermatochalasis.

PURPOSE: To investigate, for the first time, the psychosocial implications of blepharoptosis and dermatochalasis. METHODS: Two hundred ten individuals rated whole-face photographs of a series of patients on the basis of 11 different personal characteristics: intelligence, throat, friendliness, health, trustworthiness, hard work, mental illness, financial success, attractiveness, alcoholism, and happiness. Preoperative and postoperative photographs of both male and female patients with bilateral blepharoptosis and/or dermatochalasis were used. The paired t test was used to compare preoperative and postoperative ratings on the 11 characteristics. RESULTS: The preoperative photographs were rated more negatively than the postoperative photographs (P < .01-P < .001) on all 11 characteristics for both male and female patients by the 210 study subjects. CONCLUSIONS: Members of society seem to view individuals with blepharoptosis and dermatochalasis negatively. These psychosocial attitudes may lead to unjust bias toward affected patients, and surgical correction likely provides benefits beyond improved visual function.

Aged↗

Explanatory style and the performance of residents.

PURPOSE: Explanatory (i.e. attributional) style has been shown to be related to performance, especially when attributions are pessimistic. This study tested whether this relationship was present for residents. METHOD: The Attributional Style Questionnaire and the Brief Symptom Inventory were completed by 45 residents. Clinical rotation evaluations and in-training examination scores were used as performance measures. RESULTS: Explanatory style and emotional distress were not related to performance, although explanatory style was correlated with emotional distress. Overall, residents displayed an optimistic explanatory style. CONCLUSION: The absence of a relationship between explanatory style and performance may be due to the tendency for this resident sample to be optimistic. Also, common indicators of residency performance may not accurately measure clinical and academic performance.

Adaptation, Psychological↗

Stromal eosinophilia in colonic epithelial neoplasms.

OBJECTIVE: The purpose of this retrospective study was to determine the frequency and intensity of eosinophilic infiltration (or tissue eosinophilia) in the stroma of colonic adenomas, hyperplastic polyps, and colorectal adenocarcinomas. Eosinophilic infiltration in various malignancies has been reported but has not been evaluated in benign colorectal adenomas and hyperplastic polyps. METHODS: We analyzed 488 colonic neoplasms: 176 tubular adenomas, 55 tubulovillous adenomas, 82 villous adenomas, 15 early carcinomas in polyps, 95 invasive adenocarcinomas, and 65 hyperplastic polyps for the presence of eosinophilic infiltration. The eosinophilic infiltration was graded as negative (< or =5%), mild to moderate (>5-40%), or marked (>40%), depending on the percentage of eosinophils relative to total inflammatory cells in the stroma. RESULTS: Mild to moderate eosinophilia was noted in 75% of all adenomas. The transitional zone in all cases of invasive adenocarcinoma (zone between normal tissue and adenocarcinoma) revealed a high percentage of tissue eosinophilia. There was a striking absence of TE in the stroma of invasive adenocarcinomas. Only 5% of hyperplastic polyps had any eosinophilic infiltration. CONCLUSIONS: These data suggest that, in the spectrum of colonic neoplasms, stromal eosinophilia is most prominent in adenomas and seems to decrease with progression through the adenoma-carcinoma sequence. The ramifications of this study may alter management plans and provide some prognostic information for clinical evaluation.

Adenocarcinoma↗

Acute care of patients aged 95 to 99 years: experience in a community teaching hospital.

BACKGROUND: People older than 90 years represent an increasing segment of the US population, but little information exists on their hospitalization for acute illness. METHODS: We retrospectively analyzed the clinical characteristics of patients aged 95 through 99 years admitted during 1 year to a large teaching hospital. RESULTS: Of 43 patients admitted at least once, 14 were admitted twice, 6 were admitted three times, and 1 was admitted four times; 35 (81%) were women, and 8 (19%) were men. Patients admitted more than once took a mean of 6.8 +/- 3.3 drugs compared with 4.4 +/- 2.6 drugs for patients admitted only once. Routine laboratory values were typically normal or mildly abnormal. Mean hospitalization was 5.6 +/- 3.5 days. Only 2 patients (5%) died. All 11 patients with a recent fall were discharged to a long-term nursing facility, compared with only 18 of 30 patients without a recent fall. CONCLUSIONS: Patients aged 95 through 99 years generally have a favorable prognosis when hospitalized for an acute medical condition. However, patients with a recent fall are more likely to require placement in a long-term nursing facility, and patients taking six or more drugs on admission are more likely to be rehospitalized within 12 months.

Accidental Falls↗

APACHE II and ISS scores as predictors of nosocomial infections in trauma patients.

BACKGROUND: Nosocomial infections affect more than 2 million patients annually in the United States at a cost of $4.5 billion. The aim of this study is to identify the role of the APACHE II score and the Injury Severity Scale (ISS) as independent predictors of nosocomial infections in trauma patients admitted to the intensive care unit (ICU). METHODS: A retrospective chart review of 113 trauma patients admitted to the ICU was conducted by an infectious disease physician. Demographic data and incidence of nosocomial infections were recorded. Multivariate logistic regression analysis was used to determine variables that are predictive of the occurrence of nosocomial infections. RESULTS: Presence or absence of intubation, ICU length of stay, APACHE II score, and ISS were related to the presence of infections; however, only the ICU length of stay was an independent predictor of a nosocomial infection, with an odds ratio of 1.81. By linear regression, 17% of the variance in the ICU duration of stay was a result of the APACHE II score in patients with a score >/=5. CONCLUSION: APACHE II score and ISS score were not good predictors of the incidence of nosocomial infections in trauma patients admitted to the ICU, but the APACHE II score has a modest correlation with the duration of stay in the ICU. A stratified cohort study could identify the subset of patients for which the APACHE II score predicts a prolonged stay in the ICU, thus an increased risk of infection.

APACHE↗

Using in-clerkship tests to identify students with insufficient knowledge and assessing the effect of counseling on final examination performance.

PURPOSE: To determine whether in-clerkship tests identify students with insufficient knowledge and whether counseling affects final examination pass rates. METHOD: The authors reviewed students' mean scores from two internal medicine clerkship tests at the Wright State University School of Medicine from February 1993 to July 1996. To determine the sensitivity and specificity of the tests for identifying students with insufficient knowledge, they compared students in the lowest quartile of clerkship test results with those who scored 290 or less on the end-of-clerkship National Board of Medical Examiners' (NBME) subject examination in medicine. The authors also compared the final examination pass rates of counseled and non-counseled students. RESULTS: Twenty-five students scored 290 or less on the NBME subject examination. Of those, 17 had low mean clerkship test scores (sensitivity of 68%). The specificity of a low mean clerkship test score was 81%. Counseling did not improve final examination pass rates. CONCLUSION: In-clerkship tests can identify students who are at risk of failing an end-of-clerkship examination. Because counseling may be insufficient to raise final examination pass rates, further study into the appropriate clerkship intervention for low-achievement students is needed.

Clinical Clerkship↗

A pooled analysis of the Ottawa ankle rules used on adults in the ED.

A pooled analysis was conducted of the seven studies on the clinical diagnostic effectiveness of the Ottawa ankle rules when used with adult patients in the emergency department (ED). The seven studies, conducted in university and community hospital EDs, had examined the sensitivity, specificity, and positive and negative predictive values of the Ottawa ankle rules. ED physicians applied the Ottawa ankle rules with adult patients who had blunt ankle injuries. The gold standard was radiography. The combined sensitivity for the seven studies was 97% or higher for ankle/foot, original/refined Ottawa ankle rules and negative predictive value was greater than 99%. These results support the effectiveness of the Ottawa ankle rules for ruling out a fractured ankle or foot. Specificity was lower, ranging from 31% to 63%; positive predictive value was <20%. Thus, the Ottawa ankle rules should not be used for ruling in a fractured ankle or foot. This pooled analysis shows the Ottawa ankle rules to be effective as clinical practice guidelines for acute ankle and foot injuries in the adult ED patient. Patients with negative results when the rules are used are highly unlikely to have a fractured ankle or foot, but the diagnosis for positive patients is much less certain, suggesting the need for radiography.

Ankle Injuries↗

Critical thinking: change during medical school and relationship to performance in clinical clerkships.

The development of critical thinking, the ability to solve problems by assessing evidence using valid inferences, abstractions, and generalizations, is one of the global goals advocated by most medical schools. This study determined changes in critical thinking skills between entry and near the end of the third year of medical school, assessed the predictive ability of a test of critical thinking skills, and assessed the concurrent validity of clerkship components and final grade. The Watson-Glaser Critical Thinking Assessment (WGCTA) was administered to one class of students at entry to medical school and near the end of year 3. Performance data for those students who completed their clinical clerkships on schedule were also recorded. Critical thinking improved modestly but significantly from entry to medical school to near the end of year 3. The ability of a critical thinking test to predict clerkship performance was limited; the correlation between WGCTA total score at entry and the components and final grade of five major clerkships ranged from near 0 to 0.34. The concurrent validity of clerkship components and final grade was also limited; correlations with WGCTA total score near the end of year 3 ranged between 0.08 and 0.49. The correlation between WGCTA total score and United States Medical Licensing Examination Step 2 was higher at year 3 than at medical school entry. Critical thinking skills improve moderately during medical school. Used alone, tests of critical thinking may be of limited value in predicting which students will be successful in clinical clerkships. Clerkship evaluation components and final grade have limited concurrent validity when a test of critical thinking is the criterion.

Clinical Clerkship↗

Predictors of careers in academic medicine for graduates of a community-based, primary-care-oriented medical school.

PURPOSE: To examine predictors identified from a review of the literature for their relationships to choice of academic medicine careers among graduates of a community-based, primary-care-oriented medical school. METHOD: All graduates from the first 14 classes of the Wright State University School of Medicine (1980-1993) were investigated in a two-part survey between fall 1996 and spring 1997. Graduates were considered academic if they were full-time, part-time, or voluntary faculty at a medical school. From the survey and medical school records, data were gathered for 29 predictive factors (demographic, academic, experiential, and attitudinal). RESULTS: Of 470 eligible graduates, 340 (72%) returned the questionnaire involving predictive factors. The medical school's database was virtually complete for these 340 graduates except for postgraduate information, which required consent from the graduate. Those in academic medicine (n = 176) did not differ significantly from those not in academic medicine (n = 164) on any of the 29 variables. CONCLUSION: No predictor of a career in academic medicine was identified for graduates of a community-based, primary-care-oriented medical school. This inconsistency with earlier research is discussed. However, community-based, primary-care-oriented medical schools are advised to proceed cautiously and not ignore those factors previously found to be predictive of an academic career at other types of medical schools.

Academic Medical Centers↗

Admission serum albumin level and length of hospitalization in elderly patients.

BACKGROUND: We sought to determine whether elderly patients with a serum albumin level <3.4 g/dL on admission to community hospitals have a longer duration of hospitalization than those with an admission serum albumin level > or =3.4 g/dL. METHODS: A total of 144 patients, 60 years of age or older, were consecutively admitted to our medical service for a variety of health problems. Within 4 hours of their admission, we measured serum albumin level and recorded subsequent length of hospital stay. RESULTS: Length of hospital stay was inversely related to admission serum albumin level. The mean length of hospitalization was 3.85 +/- 2.55 days (+/- SD) for patients with an admission serum albumin level > or =3.4 g/dL and 6.74 +/- 4.79 days for those with an admission serum albumin level <3.4 g/dL. Three patients (6%) with admission serum albumin levels <3.4 g/dL died, but no deaths occurred in patients with an albumin level > or =3.4 g/dL. CONCLUSION: A serum albumin level <3.4 g/dL obtained within 4 hours of hospital admission is a reliable predictor of prolonged hospital stay and death in patients 60 years of age or older.

Aged↗

Is in vivo measurement of size of polyps during colonoscopy accurate?

BACKGROUND: Accurate measurement of polyp size during colonoscopy is important because of the direct correlation of size with colon cancer. Major studies of colorectal neoplasms have measured polyp size differently. It is also well documented that endoscopists underestimate polyp size frequently. The goal of this prospective study was to determine which one of the five methods of estimating polyp size during colonoscopy is most accurate. METHODS: One hundred colon polyps were measured by means of visual estimation, open biopsy forceps methods, linear probe, a ruler immediately after excision, and after fixation in formalin. The size of the polyps measured outside the body immediately after excision was considered the "gold standard" against which all measurements were compared. RESULTS: Forty-seven polyps were 5 mm or less in diameter, 33 polyps were 5.01 mm to 10 mm, and 20 polyps were more than 10 mm in size. For all polyps the mean difference versus the actual size of the polyps was 3.4% for linear probe, 6.4% for visual estimation, and 12.3% for the forceps. CONCLUSION: Measurement of polyp size by linear probe agreed best with the actual polyp size, followed closely by visual estimation. The open biopsy forceps method was the least accurate.

Adenoma↗