Lithium: an anaesthetic risk.
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Biomedical subjects
Publications and source records attributed to R J Kerry.
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In a group of patients suffering from manic depressive illness treated with lithium carbonate occasional large increases in creatine phosphokinase (C.P.K.) activity were seen. These were found to occur at times when the patients were stable in mood and clinically well. The serum lithium levels were adequate in all cases at the time of raised C.P.K. activity. Raised C.P.K. activity can be an indication that the disease is active but is controlled by lithium.
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A double-blind crossover comparison of medazepam 10 mg three times a day against amylobarbitone 60 mg three times a day in outpatients with neurotic anxiety showed that medazepam was superior in relieving symptoms. At this dose of medazepam drowsiness or ataxia was rarely a problem.
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