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Biomedical subjects

R J Kaplan

Publications and source records attributed to R J Kaplan.

36 records · Page 2Linked to original sources
PubMed1978

Topical use of caffeine with hydrocortisone in the treatment of atopic dermatitis.

In a double-blind study, topically applied caffeine 30%-hydrocortisone 0.5% in hydrophilic ointment was compared to betamethasone valerate 0.1% cream and to hydrocortisone 0.5% in hydrophilic ointment. Eighty-three patients were evaluated over a three-week period for pruritus, erythema, scaling, lichenification, excoriation, oozing, and global impression. The betamethasone and caffeine-hydrocortisone groups performed significantly better than the hydrocortisone group on three of the seven scales: lichenification, excoriation, and global impression. Also, the betamethasone group differed significantly from the hydrocortisone group on six of the seven scales, but did not differ significantly from the caffeine-hydrocortisone group on any scale. It is suggested that caffeine is effective because it elevates local levels of cyclic adenosine-3',5'-monophosphate by inhibiting phosphodiesterase.

Administration, Topical↗
PubMed1977

Disseminated histoplasmosis in an immunosuppressed patient.

A renal transplant recipient was receiving prednisone and azathioprine therapy when he developed fever, cough, and erythema-nodosum-like lesions on the extremities. Disseminated histoplasmosis was diagnosed by skin biopsy. Disseminated histoplasmosis should be considered when a patient under immunosuppressive therapy develops a lesion similar to erythema nodosum or erysipelas with panniculitis.

Azathioprine↗
PubMed1977

Pustular blastomycosis.

A 53-year-old Negro man had North American blastomycosis with acute onset of widespread pustular eruptions. Several tests suggested that the patient might have had a deficiency of delayed hypersensitivity.

Blastomycosis↗
PubMed1976

Chronic urticaria and intermittent anaphylaxis. Reactions to lophendylate.

In a case of chronic, severe urticaria and intermittent episodes of anaphylaxis due to an iophendylate injection (Pantopaque) given in the course of myelography, almost complete relief was obtained from the removal of approximately 8 ml of residual iophendylate from the spinal canal. Data obtained from direct skin testing, Prausnitz-Küstner testing, peptide inhibition of Prausnitz-Küstner testing, and IgE levels quantitated before and after removal of iophendylate indicate that these symptoms were mediated via an IgE anti-iophendylate reaction.

Anaphylaxis↗
PubMed1976

Squamous-cell and basal-cell carcinomas in black patients.

Squamous-cell and basal-cell carcinomas of the skin are rare in black patients. Etiologic factors, body distribution, and aggressiveness of these cancers in blacks are discussed. The roles of ultraviolet light and pigment dispersion are noted.

Black People↗