Biomedical subjects
R J Joynt
Publications and source records attributed to R J Joynt.
Financial threats to hospital libraries.
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Lucretia W. McClure. Medical Library Association President 1990-1991.
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Vascular dementia: too much, or too little?
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Neural transplants: are we ready?
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HTLV-III/LAV and the monocyte/macrophage.
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Amitotic neuroblastoma cells used for neural implants in monkeys.
The potential utility of cultured neuroblastoma cells as donor tissue for neutral implants into the mammalian brain has been examined. Cells from a human neuroblastoma cell line, IMR-32, were labeled with [3H]thymidine and chemically rendered amitotic. These differentiated IMR-32 cells were grafted into the hippocampi of five adult African Green monkeys, and graft survival was evaluated for up to 270 days after transplantation. Autoradiographically labeled grafted cells were identified in four animals. Processes from grafted cells could be followed for distances of up to 150 micrometers into the host brain. No evidence for neoplastic growth of the transplant was found. Thus, grafted neuroblastoma cells can survive for prolonged periods in the primate brain and may serve as a practical source of donor tissue for neural implants.
Return to work after stroke.
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Cerebral dominance.
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Landmark perspective: A new look at death.
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Neuropeptides in aging and dementia.
Although senile dementia of the Alzheimer's type (SDAT) is a common disease associated with advancing age, recent studies have suggested that SDAT should not be considered synonymous with old age but a disease process separate from normal aging. This study examined the morphology of two neurochemically-defined neuronal populations (i.e., neurophysin, somatostatin) in the cortex and hypothalamus to determine if structural changes in these neuropeptide systems associated with advancing age are similar to those seen with SDAT. Our findings suggest that morphological changes consistent with neuronal degeneration occur in somatostatin but not neurophysin-containing neurons in cases diagnosed to have SDAT, and these structural changes are different from those seen in aged brain without central nervous system disease. These data support the concept that senile dementia of the Alzheimer's type is not a single neurochemical related disease, but may be associated with anatomical lesions and biochemical imbalances among a number of neuropeptide and neurotransmitter systems.