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Biomedical subjects

R J Hunt

Publications and source records attributed to R J Hunt.

At least 37 records · Page 2Linked to original sources

The distribution and interrelationship of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, and BANA scores among older adults.

In a random sample of subgingival dental plaque samples from 375 blacks and 300 whites aged 65 and older, immunofluorescence assays for 3 target pathogens including Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia, and BANA enzyme analysis were carried out. Blacks had significantly greater proportions of P. gingivalis and P. intermedia in their subgingival plaque and had significantly higher BANA scores. These assay results were investigated for concordance with each other and with 2 cariogenic salivary bacteria, Streptococcus mutans and lactobacilli. In general for both races, the periodontal pathogens were more likely to occur in combination with each other than with either S. mutans or lactobacilli. P. gingivalis and P. intermedia were more frequently associated with each other than with A. actinomycetemcomitans. There was a significant negative concordance between BANA and A. actinomycetemcomitans in whites and a significant positive concordance between BANA and P. intermedia in blacks.

Black or African American↗

Conservative management of femoral diaphyseal fractures in four foals.

Femoral fractures in young horses can occur as a result of severe trauma and generally have a poor prognosis despite treatment. Four young horses with femoral diaphyseal fractures were managed with conservative treatment consisting of prolonged rest, analgesics, hind limb support, and corrective farriery. A favorable outcome in the form of pasture soundness with potential for limited athletic usefulness was obtained in 3 out of the 4 cases. This report supports the use of conservative treatment of selected diaphyseal femoral fractures in young horses.

Animals↗

Tension-band wiring and lag screw fixation of a transverse, comminuted fracture of a patella in a horse.

A transverse, comminuted fracture of the patella was treated surgically by combining tension-band wiring and lag-screw fixation in a horse. Partial patellectomy or smaller detached fragments of the patella was performed. Satisfactory healing of the fracture was evident 10 weeks after surgery, and there were no complications. Implants were not removed. The horse was sound at a trot 4 months after surgery and was used for pleasure riding 8 months later.

Animals↗

Assessing dental practice quality by evaluating radiology items.

The DEMCAD dental office assessment instrument was developed to evaluate practice quality using Donebedian's quality assessment model of structure, process, and outcome. This previously validated instrument takes about six hours to complete. Subsequent analysis was undertaken to determine whether an abbreviated office assessment based on the evaluation of radiology items was sufficiently sensitive, specific, and practical to be used as a screening instrument for identifying dental offices with very low evaluation scores. Data for this analysis were obtained from 300 volunteer general dental practices evaluated in the field testing of the DEMCAD instrument. The nine radiology structure items predicted very poorly the overall structure scores. However, 13 radiology process items predicted overall process scores quite accurately. Four of the 13 radiology process items (periodontal diagnoses recorded, interdental bone shown on x-rays, caries diagnoses recorded, and current x-rays mounted) produced a combined R2 of .58. These four radiology variables predicted the 10 percent of the dental practices with the lowest overall process score with 87 percent sensitivity and 93 percent specificity. This analysis showed that an abbreviated dental practice process quality assessment using oral radiology items in an audit of patients' records may be feasible as a screening test for dental office assessment.

Alveolar Process↗

Repair of a ruptured calcaneal tendon by transposition of the tendon of the peroneus longus muscle in a goat.

Traumatic rupture of the calcaneal tendon was diagnosed in a 3-year-old female goat. Clinical features included tarsal hyperflexion and diffuse swelling in the area of the calcaneal tendon. Surgical repair consisted of debridement of devitalized tissue and transposition of the tendon of the peroneus longus muscle to bridge the calcaneal tendon defect. Adequate postoperative immobilization followed by gradual introduction of tendon loading allowed a favorable outcome.

Animals↗

Five-year incidence of tooth loss in Iowans aged 65 and older.

The prevalence of missing teeth has been described for US adults, but little is known about the incidence of tooth loss in any segment of the population. This study investigated the 5-yr incidence of tooth loss in a random sample of Iowans aged 65 yr and older residing in two rural counties. These people had an average of 20 teeth at baseline and approximately 40% lost at least one tooth in the subsequent 5 yr. The incidence of tooth loss was highest for mandibular molars and lowest for mandibular canines. Men were more likely than women to lose teeth. Although we were able to identify a number of statistically significant potential risk factors for tooth loss, the multivariate models that incorporated all these factors were not good predictors of which people were at highest risk for tooth loss.

Aged↗

Effect of examining half the teeth in a partial periodontal recording of older adults.

Limited evidence to date has suggested that half-mouth examinations can be used in epidemiological surveys for accurate estimation of the prevalence of periodontal conditions. This study investigated the accuracy and efficiency of half-mouth periodontal examinations of mesial and buccal sites by comparing whole-mouth findings from those sites with findings that would have been obtained by examining only two randomly selected quadrants of teeth in three older dentate adult populations: 263 whites in Iowa, 309 whites in North Carolina, and 384 blacks in North Carolina. Mean half-mouth scores for gingival recession, pocket depth, attachment loss, and Extent and Severity Index were almost identical to those of mean whole-mouth scores, with correlations between means exceeding 0.93. However, the proportions of the population having selected levels of moderate or severe periodontal disease in mesial and buccal sites were underestimated by as much as 13%. This study showed that half-mouth examinations can be accurate and efficient in estimating mean periodontal measures, but may underestimate the prevalence of periodontal conditions.

Aged↗

Intracranial trauma associated with extraction of a temporal ear tooth (dentigerous cyst) in a horse.

Heterotopic polyodontia is typically associated with a sinus and a fistulous tract with a secreting membrane which extends to an ectopic tooth attached to the temporal bone. Recommendations for treatment include complete excision of the tract, the dental component, and the lining of the alveolar socket. Iatrogenic cerebral trauma was encountered during surgical extraction of an ectopic tooth. At post-mortem examination a second ectopic tooth was found compressing the right side of the cerebellum.

Animals↗

Testicular seminoma associated with torsion of the spermatic cord in two cryptorchid stallions.

Two adult horses had colic attributable to spermatic cord torsion and strangulation of abdominally retained neoplastic testes. Both horses had caudal abdominal soft tissue masses palpable per rectum. One horse was treated successfully by surgical removal of the testis, and the other was euthanatized without treatment. Histopathologic diagnosis of the involved testes was testicular seminoma. Spermatic cord torsion of an abdominally retained testis should be considered in the differential diagnosis of signs of abdominal pain in cryptorchid stallions, especially those with a palpable caudal abdominal mass.

Animals↗

The prevalence of periodontal attachment loss in an Iowa population aged 70 and older.

Survey dental examinations were conducted in 262 dentate elderly people aged 70 and older and residing in two rural Iowa counties. Over 60 percent of the elderly in these countries were dentate. Buccal and mesial sites of all teeth were assessed for gingival recession, pocket depth, and attachment loss. Mean loss of periodontal attachment was 2.1 mm, and was slightly greater in older age groups and in men. More gingival recession was found on buccal sites and deeper pocketing was found on mesial sites regardless of age group, sex, or tooth type. However, the clinical magnitude of these differences was small. The prevalence of advanced periodontal breakdown was relatively low, with less than 15 percent of the subjects having at least one site with attachment loss of 7 mm or more. However, moderate periodontal breakdown was highly prevalent in this older population.

Aged↗

An evaluation of radiographic equipment and procedures in 300 dental offices in the United States.

As part of the development and testing of a dental practice quality assessment instrument, data were gathered regarding the radiological practices of a nationwide sample of 300 general dentistry offices. The distribution of assessment scores was compared for practice size (solo versus nonsolo) and practice age (1-19 years versus 20 or more years). Practice habits varied widely, from a high of 99% of the offices using a leaded apron to a low of 23% of the offices having a written policy regarding the use of ionizing radiation. Most offices successfully managed administrative items such as mounting and dating radiographs. However, for items such as radiographic exposure, tissue coverage, and radiographic interpretation, general performance was fair.

Dental Offices↗

Validation of oral status indicators.

In planning programmes and developing policy, dental public health officials rely on epidemiological data in the form of composite measures such as the DMFT index. However, the DMFT is often not sufficiently sensitive to detect differences in oral health between population groups. Measures that selectively weight components of the DMFT may be better dental indicators. Sheiham, Maizels and Maizels (1987) suggested a functional measure (FM) that weights filled and sound teeth equally and a tissue health (T-health) measure that differentially weights decayed, filled, and sound teeth. For the present analysis, these indicators were divided by 28 to make their range 0 to 1. The modified indexes are called FMI and THI. Carpay et al. (1988) also suggested a dental health index (DHI) that scores a subset of teeth. Data from 797 participants in the 1980 Iowa Survey of Oral Health that included eight independent variables were used to perform stepwise regression on DMFT, FMI, THI, and DHI to assess how well the independent variables correlated with these four dental indicators. R-square values were 0.37 for FMI and 0.36 for THI, but only 0.19 for DHI and 0.12 for DMFT, suggesting that the FMI and THI were more sensitive as dental health indicators. In addition, calculations made on aggregate data published from three national surveys show that the FMI and THI can detect changes in oral health over time. Because the FMI and THI are as easy to measure and calculate as the DMFT, but appear to be more sensitive, they show promise as indicators of oral health status.

Adolescent↗

Effect of endotoxin administration on equine digital hemodynamics and starling forces.

Using a pump-perfused extracorporeal isolated digital preparation, the effects of a 30-minute infusion of either saline solution (control) or endotoxin on equine digital hemodynamics and microvascular function were determined. Digital blood flow and arterial, venous, and capillary pressures were recorded at 15-minute intervals for 150 minutes. From these data, total vascular resistance and pre- and postcapillary resistances were calculated. Isogravimetric capillary filtration coefficient, vascular compliance, and the osmotic reflection coefficient were determined after the last hemodynamic measurements were taken. Changes in hemodynamic values of control equine digits were not observed. During the 120 minutes after infusion of endotoxin, digital blood flow decreased 43%, and total vascular resistance increased 89%. Precapillary resistance increased 122%, but postcapillary resistance did not change significantly. Changes in vascular compliance or the capillary filtration coefficient were not observed in response to either treatment. The osmotic reflection coefficient, an index of permeability, did not differ significantly between digits of the endotoxin-treated and control groups. These data indicate that the increase in vascular resistance during endotoxemia may have been attributable to arterial/arteriolar constriction and that neither the permeability nor the surface area of the exchange vasculature within the digit was significantly affected by endotoxin. Although marked alterations in vascular function are seen after administration of endotoxin, these changes do not parallel those documented in association with experimentally induced laminitis.

Animals↗

Hemodynamic responses of the equine digit to intravenous and digital arterial infusion of dopamine.

In 6 adult horses anesthetized with pentobarbital, the hemodynamic responses of the equine digit to infusion of dopamine were evaluated by use of an isolated extra corporeal pump perfused digital preparation. Digital blood flow was maintained at a constant rate that was independent of systemic hemodynamic changes. Three sequential experiments were performed on each horse. In the first experiment (n = 6), dopamine was infused IV at rates of 1.0, 2.5, and 5.0 micrograms/kg/min. For the second experiment (n = 5), dopamine (400 micrograms/ml) was infused into the digital artery at the rates of 0.07, 0.7, and 1.2 ml/min. The third experiment (n = 5) consisted of a 5-minute intra-arterial infusion of phentolamine followed by the intra-arterial infusion of dopamine while continuing the infusion of phentolamine. Digital venous, arterial, and capillary pressures, total digital vascular resistance, and precapillary to postcapillary resistance ratios were determined in each experiment. Systemic infusion of dopamine did not induce changes in the hemodynamics of the digital vasculature. Digital arterial infusion of dopamine alone resulted in a dose-dependent increase in arterial pressure, total digital vascular resistance, and an increase in the precapillary to postcapillary resistance ratio. Phentolamine attenuated the vasoconstrictive response elicited by intra-arterial infusion of dopamine.

Animals↗

Effect of residence in a fluoridated community on the incidence of coronal and root caries in an older adult population.

Eighteen-month caries incidence among older adult residents of fluoridated and nonfluoridated communities was compared. Rates for both coronal and root caries were consistently lower among long-term residents of the fluoridated communities than among life-long residents of nonfluoridated communities. Coronal caries incidence was significantly lower for people who had resided in fluoridated communities for more than 30 years (1.95 vs 1.33 surfaces). Root caries incidence was significantly less among residents for more than 40 years (0.56 vs 1.11 surfaces). Fluoridation appeared to be beneficial for the older adults examined, even though the exposure to fluoridated water began in adulthood.

Aged↗

Treatment of patent urachus associated with a congenital imperforate urethra in a calf.

Patent urachus is a common condition in calves which is frequently associated with omphalitis. A membranous urethral diaphragm prevented closure of the urachus in a female calf. The patent urachus was complicated by an ascending infection of the intraabdominal umbilical remnants. Following surgical removal of the urachus and umbilical vessels along with transection of the membranous diaphragm the calf experienced an uncomplicated recovery. This case stresses the importance of assuring urethral patency when managing a case of patent urachus.

Abnormalities, Multiple↗

The prevalence of AIDS-associated oral lesions in a cohort of patients with hemophilia.

Oral and perioral lesions have been widely reported in homosexual males and intravenous drug abusers who are seropositive for the human immunodeficiency virus (HIV) or have acquired immunodeficiency syndrome (AIDS). Several case reports have also noted some AIDS-associated lesions among persons with hemophilia, but the prevalence of these lesions in hemophilia populations is not known. This study investigated the prevalence of oral and perioral lesions in a cohort of patients receiving care at a hemophilia treatment center. In a sample of 32 patients with a factor VIII deficiency and 5 patients with a factor IX deficiency who underwent oral examinations, more than 80% were HIV seropositive. Cervical lymphadenopathy was present in more than half of the patients who were HIV seropositive but was absent in those who were HIV seronegative. Intraoral AIDS-associated lesions were present only in patients for whom a diagnosis of AIDS had been made, indicating that oral lesions among persons with hemophilia who are HIV seropositive may be less prevalent than among homosexual males or intravenous drug abusers who are HIV seropositive.

Acquired Immunodeficiency Syndrome↗

Incidence of coronal and root caries in an older adult population.

Incidence rates for new root caries and new coronal caries in noninstitutionalized older adults are unknown. In this study, a representative sample of 451 elderly Iowans received dental examinations at the start of the study and again after 18 months. This dentate cohort had a mean of 0.87 new surfaces of coronal decay per person per year and a mean of 0.57 new surfaces of root decay per person per year. Coronal caries occurred at an annual rate of 1.4 surfaces per 100 susceptible coronal surfaces. Root caries occurred at an annual rate of 2.6 surfaces per 100 susceptible root surfaces. This study shows that both coronal and root caries were active in this older population, indicating a need for emphasis on the prevention and treatment of dental caries in older adults.

Aged↗