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Biomedical subjects

R J Huebner

Publications and source records attributed to R J Huebner.

At least 145 records · Page 8Linked to original sources
PubMed1971

Specific inhibition of mammalian ribonucleic acid C-type virus deoxyribonucleic acid polymerases by rat antisera.

Inhibition of the ribonucleic acid (RNA)- and deoxyribonucleic acid (DNA)-dependent DNA polymerase activities of mammalian C-type viruses was obtained with sera from rats bearing murine leukemia virus-induced transplant tumors. Polymerase activities of nonmammalian (viper) C-type virus and murine mammary tumor virus were not inhibited by such sera nor by serum from a rat immunized with the DNA polymerase of feline leukemia virus purified by isoelectric focusing. The latter serum appeared to inhibit preferentially the DNA-dependent DNA polymerase activity of mammalian C-type viruses showing no inhibition of RNA-dependent DNA synthesis.

Animals↗
PubMed1970

Feline leukemia and sarcoma viruses: susceptibility of human cells to infection.

Human embryonic cells are highly susceptible to infection with feline leukemia and sarcoma viruses. These viruses were propagated in human cultures without antigenic modification or loss of infectivity for cat or human cells. Virus stocks contained at least 10(6) infectious units of virus per milliliter for human cells. Virus present in 10(-6) dilution of virus stock replicated to detectable amounts as early as 7 days after virus infection. The feline sarcoma virus induced morphological transformation of human cells.

Animals↗