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Biomedical subjects

R J Hawley

Publications and source records attributed to R J Hawley.

76 records · Page 5Linked to original sources
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TRH-induced reflex changes in patients with ALS.

A trial of Thyrotropin Releasing Hormone (TRH) 5.0 mg/kg body weight subcutaneously every other day for two weeks produced transient increased tone in muscles, along with other (side-) effects in patients with Amyotrophic Lateral Sclerosis (ALS). One patient's extensor plantar transiently changed to a flexor plantar reflex after injection, probably due to disproportionate increase in tone of the calf muscles. No significant changes in F-waves or H-reflexes were seen. No increase in useful voluntary strength, or in strength measured by Medical Research Council (MRC) testing or strain gauge isometric strength testing was seen. However, dyspnea was seen within 10 minutes of TRH injection.

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Reproduction of radicular symptoms by paraspinal muscle EMG needling.

With a frequency of 0.3-0.5%, patients who had cervical and lumbosacral radiculopathies had their symptoms of radicular pain or paresthesia reproduced during needling of the paraspinal muscles at the level of the lesion. The occurrence of the patient's symptoms during paraspinal EMG needling is an insensitive but specific diagnostic sign which helps establish the level of a root lesion.

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