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Biomedical subjects

R J Harrison

Publications and source records attributed to R J Harrison.

At least 73 records · Page 4Linked to original sources
PubMed1971

Vitamin B 12 levels in erythrocytes in hypochromic anaemia.

Vitamin B(12) levels in erythrocytes were low in untreated hypochromic anaemia, rose to abnormally high levels during therapy with iron alone, and finally slowly fell to normal. These changes were similar to those previously found in pernicious anaemia in response to vitamin B(12) therapy and in folate-deficiency anaemia in response to folic acid, thus changes in erythrocyte B(12) levels are not always due directly to changes in B(12) metabolism but may be secondary to changes in the levels of other haematinic factors.

Anemia, Hypochromic↗
PubMed1971

Ocular myopathy.

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Adult↗
PubMed1970

Familial thyroxine-binding globulin deficiency.

Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemical results disclosed the diagnosis and emphasize that serum protein bound iodine levels should be interpreted carefully and tests, such as triiodothyroinine (T3) or T4 resin uptake, used to prevent erroneous diagnoses of hypothyroidism.

Adult↗
PubMed1970

Vitamin B12 levels in erythrocytes in normal subjects and in pernicious anaemia.

A reliable method is described for the assay of vitamin B(12) activity in erythrocytes using Lactobacillus leichmannii. The results are shown for age, sex, and blood group in normal subjects, and before, during, and after therapy in vitamin B(12) deficiency anaemia. The normal range is 85-225 pg/ml (mean = 155 +/- 35 pg/ml). Raised levels were found in the newborn, and subnormal levels in subjects aged 70 years and over and in males aged 10 to 19 years. There were no differences in erythrocyte vitamin B(12) levels between the ABO or Rhesus blood groups. In pernicious anaemia low levels are found before treatment (mean = 91 pg/ml), followed by a rapid rise during vitamin B(12) therapy (mean peak = 482 pg/ml), and falling more slowly towards normal after the initial haematological response.

ABO Blood-Group System↗