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Biomedical subjects

R J Hafner

Publications and source records attributed to R J Hafner.

At least 37 records · Page 2Linked to original sources

Attitudes of psychiatric patients and their relatives to involuntary treatment.

In 1979 a Guardianship Board assumed responsibility in South Australia for the welfare of those mentally ill or handicapped people unable to look after their own health or safety, or to manage their own affairs. This study examines the attitudes to guardianship and involuntary treatment of 79 patients referred to the Board from a psychiatric hospital, all of whom were under guardianship at the time of the study. Forty-seven of their relatives took part in the project, which included measures of patients' psychiatric symptoms and relatives' punitiveness. Although almost 70% of patients objected to Guardianship in principle, they made more positive than negative statements about it. Nearly 60% rated involuntary treatment, including medication, as helpful. Patients reported a level of psychiatric symptoms less than half of that of a psychiatric outpatient sample. Relatives were strongly in favour of Guardianship, stating frequently that it allowed an improved relationship between themselves and the patient. Patients who believed that they were suffering from a mental illness were comparatively happy about being under Guardianship, and a belief that the patient was mentally ill was significantly associated with reduced extrapunitiveness in relatives.

Activities of Daily Living↗

Morbid obesity: effects on the marital system of weight loss after gastric restriction.

Eighty morbidly obese married women and 69 of their husbands completed a self-report measure of personal and marital adjustment before the women proceeded to gastric restriction surgery. Fifty-five women and 41 husbands repeated the measure 12 months after surgery, at which time the women had lost a mean of 35.4 kg. Women rated themselves as significantly more attractive and sociable, and rated their husbands as significantly less sociable and interesting, than before surgery. Husbands rated their wives as excessively sociable after surgery, the reverse of their previous view. The data offered some support for a family systems view of morbid obesity, but the systemic effect appeared weak, and is probably not a major contributor to wives' morbid obesity in most cases.

Adult↗

Essential hypertension: hostility, psychiatric symptoms and marital stress in patients and spouses.

Scores on self-report questionnaire measures of hostility, psychiatric symptoms, marital dissatisfaction, and assertion discomfort/behaviour were compared for male (n = 26) and female (n = 25) patients with essential hypertension and their spouses, and matched normotensive controls. Correlations and factor analysis revealed clinically meaningful associations between elevated psychiatric symptoms, hostility, and assertive behaviour. These differed for male and female patients, especially regarding assertive behaviour. The findings suggest that communication training might be helpful for a sizeable proportion of married patients with essential hypertension.

Adult↗

Quality of life after gastric bypass for morbid obesity.

One year after gastric restriction surgery, 70 per cent of 118 women completed a questionnaire about lifestyle and eating behaviour changes. Mean weight loss was 35.4 kg. Patients reported a moderate reduction in appetite, and most avoided specific foods which they previously enjoyed, usually because of epigastric discomfort and/or nausea and vomiting. Patients had initiated or resumed a mean of 1.8 activities, most of which involved physical exercise. Sexual interest, enjoyment and frequency were all increased. Raised sexual satisfaction correlated strongly with overall outcome satisfaction. Seventy-two per cent of respondents rated themselves as very pleased, and 18 per cent as fairly pleased, with the overall results of the operation, and responses to the open-ended questions were often strikingly enthusiastic. However, most patients emphasized the difficulty of adjusting to radically new eating habits in the first 2-3 months after surgery, during which they experienced their greatest need for social support and encouragement.

Adult↗

Psychological status before and after gastric restriction as predictors of weight loss in the morbidly obese.

Before gastric restriction, 118 morbidly obese women were psychiatrically assessed by clinical interview and self-report questionnaire. One year after surgery, 71 repeated the questionnaires. Weight was assessed at yearly intervals until the four year follow-up (n = 91). The maximum mean weight loss of 35 kg occurred at one year follow-up, when questionnaire respondents reported a slight overall improvement in personal and marital adjustment, and 72% rated themselves as very pleased with the results of surgery. Subsequently, 70% of patients regained weight, although the mean annual increase was only 1.9 kg. Marital dissatisfaction was a significant positive predictor of weight at one year, and generalized anxiety was a significant negative predictor of weight at four years. An increase in phobia scores at one year predicted subsequent maintenance of weight loss, whereas an increase in extrapunitiveness (mainly irritability and criticism of others) predicted subsequent weight gain.

Adult↗

Persistent auditory hallucinations and their relationship to delusions and mood.

Twelve patients who met DSM-III-R criteria for schizophrenia and had persistent auditory hallucinations completed a diary three times daily for 2 to 3 weeks. Using 5-point equal interval rating scales, nearly all patients were able to record consistently the nature of their hallucinations, the intensity of their delusional beliefs, and the mood and clarity of their thinking. For at least half the patients, there was a statistically significant relationship between the loudness and intrusiveness of hallucinations and the intensity of delusional beliefs; the more intrusive and distressing were the hallucinations, the more anxious and depressed were the patients. The findings suggested that more emphasis might be placed on altering patients' mood in the treatment of persistent hallucinations. The diary approach to research into auditory hallucinations appears promising.

Adult↗

Obsessive-compulsive disorder: an exploration of some unresolved clinical issues.

The study data were obtained from a questionnaire survey of a South Australian community support group for obsessive-compulsive disorder (OCD). The response rate was 47%, yielding 81 questionnaire sets completed by members who, on the basis of their questionnaire responses, were judged to meet DSM-III-R criteria for OCD. The clinical and demographic characteristics of the respondents were very similar to those of previously reported clinical populations. Mean age at onset of OCD was 18 years and mean duration 17 years; 55% of respondents rated their current OCD as extremely or very severe. Seventy-seven percent had received psychiatric treatment (mean 55 occasions) and 47% had attended clinical psychologists or professional counsellors (mean 20 occasions). Those who reported prominent fears of losing control of motor behaviours had received a significant excess of outpatient and inpatient psychiatric treatment. Most respondents reported the presence of all 4 identified components of OCD, of which the obsession/rumination component was central. Levels of OCD correlated strongly with levels of overall psychopathology, and fertility rates were significantly reduced in those patients who reported the most symptoms.

Adult↗

Husbands' adjustment to wives' weight loss after gastric restriction for morbid obesity.

This study examined the personal and marital adjustment of husbands before and one year after their wives had gastric restriction surgery for morbid obesity. Seventy-five married women and their husbands were assessed by clinical interview and self-report questionnaires before surgery. Forty-three husbands (57 per cent) returned questionnaires at the 12 month follow-up, and in 36 cases both partners did so. Four couples separated in the first year after surgery. Husbands' self-reported personal adjustment before surgery was essentially normal, but their marital dissatisfaction was significantly elevated. Twelve months after surgery, their scores improved on the measure of psychoneurotic symptoms, and on assertion discomfort, extrapunitiveness and marital dissatisfaction. However, there was a significant reduction in assertion behaviour. In contrast, wives (who had lost an average of 35.4 kg) reported significant increases in extrapunitiveness and assertion behaviour, the latter increase being associate with raised marital dissatisfaction in husbands. This finding suggested that husbands' adaptation to wives' increased assertiveness is often a problem in the first year after surgery, confirming reports in the clinical literature.

Adaptation, Psychological↗

The FIRO model of family therapy: implications of factor analysis.

Schutz's FIRO model contains three main elements: inclusion, control, and affection. It is used widely in mental health research and practice, but has received little empirical validation. The present study is based on factor analysis of the resources to FIRO questionnaire of 120 normal couples and 191 couples who were attending a clinic for marital/psychiatric problems. Results confirmed the validity of the FIRO model for women only. The differences between the sexes reflected a considerable degree of sex-role stereotyping, the clinical implications of which are discussed.

Adult↗

Lysis of Escherichia coli by the bacteriophage phi X174 E protein: inhibition of lysis by heat shock proteins.

Lysis of Escherichia coli by the cloned E protein of bacteriophage phi X174 was more rapid than expected when bacteria were shifted from 30 to 42 degrees C at the time of E induction. Since such treatment also induces the heat shock response, we investigated the effect of heat shock proteins on lysis. An rpoH mutant was more sensitive to lysis by E, but a secondary suppressor mutation restored lysis resistance to parental levels, which suggests that the sigma 32 subunit itself did not directly increase lysis resistance. At 30 degrees C, mutants in five heat shock genes (dnaK, dnaJ, groEL, groES, and grpE) were more sensitive to lysis than were their wild-type parents. The magnitude of lysis sensitivity varied with mutation and strain background, with dnaK, dnaJ, and groES mutants consistently exhibiting the greatest sensitivities. Extended protection against lysis occurred when overproduction of heat shock proteins was induced artificially in cells that contained a plasmid with the rpoH+ gene under control of the tac promoter. This protective effect was completely abolished by mutations in dnaK, dnaJ, or groES but not by grpE or groEL mutations. Altered membrane behavior probably explains the contradiction whereby an actual temperature shift sensitized cells to lysis, but production of heat shock proteins exhibited protective effects. The results demonstrate that E-induced lysis can be divided into two distinct operations which may now be studied separately. They also emphasize a role for heat shock proteins under non-heat-shock conditions and suggest cautious interpretation of lysis phenomena in systems where E protein production is under control of a temperature-sensitive repressor.

Bacterial Proteins↗

Sex differences in the phenomenology of schizophrenic disorder.

The content and structure of delusions were compared in 30 women and 30 age-matched men with Schizophrenic Disorder. Men showed an excess of homosexual persecutory delusions and of grandiose delusions involving social status and personal power. Women showed an excess of delusions of fertility and of jealousy, and were more often than men objects rather than subjects in their grandiose delusions. There was an excess of women who reported co-objects of persecution, and who personally knew their persecutors, nearly always men. These differences mirrored aspects of the social environment, especially with regard to sex-role stereotyping.

Adult↗

The use of seclusion: a comparison of two psychiatric intensive care units.

The use of seclusion within a psychiatric intensive care unit in a South Australian metropolitan mental hospital was documented over a ten week period. The seclusion rate within the unit was 32% of all admissions and 34% of new admissions. The overall seclusion rate for the hospital was 5.4% of all admissions and 6.3% of new admissions, somewhat higher than in the United Kingdom but considerably lower than in the Eastern United States. A comparison was then made between consecutive new admissions (30 secluded and 30 non-secluded) to this unit and to a similar unit without a seclusion room in the other mental hospital in the State. Although seclusion offered no clear advantages in terms of duration of admission, levels of medication or relapse rates, it appeared to reduce the level of dangerousness in the unit, thereby enhancing staff morale. The overall mean daily total of neuroleptic medication was about 1,200 mg chlorpromazine equivalent, somewhat less than in comparable units in the United States and Europe.

Adult↗

Use of seclusion in a psychiatric intensive care unit.

OBJECTIVE: To evaluate the use in a psychiatric intensive care unit of a newly introduced seclusion room for the management of acutely disturbed and/or violent patients. METHOD: A specially designed seclusion chart was used to document fully events immediately before, during, and immediately after seclusion. Data from the charts over a 6-month period provided the basis for the study. RESULTS: The seclusion rate of about 2% of all admissions is less than that reported in the UK and the USA, suggesting that the facility is not used exclusively. Nursing staff welcomed seclusion as a means of reducing levels of dangerousness in the unit, but emphasized that it should be monitored carefully in order to prevent inappropriate use.

Clinical Protocols↗

Residents' evaluation of a therapeutic community.

OBJECTIVE: To determine former residents' views of a therapeutic community and factors associated with a good response to therapy. METHOD: Retrospective, using a self-report questionnaire. RESULTS: Of 51 contactable former residents, 32 completed the questionnaire. Responses were generally very positive, although the best outcome was reported by those who held a social-interpersonal rather than a biological view of psychiatric disorder, and who scored close to normal on a measure of intropunitiveness. Respondents emphasized the crucial role of feedback and confrontation by staff and co-residents in changing their unhelpful behaviour and attitudes, although a few thought that confrontations were too forceful. The mean duration of psychiatric disorder (mainly substance abuse and personality disorder) was more than 4.5 years. Many respondents emphasized the failure of orthodox treatments to help them, adding that their disorders would probably have continued indefinitely without treatment in a therapeutic community.

Adult↗

Marriage duration, marital adjustment and psychological symptoms: a cross-sectional study.

One hundred and nine couples completed questionnaire measures of psychological symptoms, personality, and marital adjustment. They were divided into groups of short, intermediate, and long marriage duration. Psychological symptoms and marital adjustment remained fairly stable over time, although wives scored significantly worse than husbands on most measures in the intermediate duration group. In the short marriages, half the variance in marital satisfaction was predicted by the partner's marital questionnaire score, but when this variable was eliminated from the regression equation, psychological symptoms (phobic anxiety in wives and depression in husbands) were the main predictors of marital satisfaction. In the intermediate group, hostility levels were the main predictors of marital satisfaction. In the long marriages, marital satisfaction was predicted mainly by personality factors (assertiveness in husbands and personal flexibility in wives) and by levels of generalized anxiety. The findings suggest that couples who constructively resolve difficulties in expressing hostility within marriage are more likely to remain married than those who fail to do so.

Adaptation, Psychological↗

Obsessive-compulsive disorder: a questionnaire survey of a self-help group.

Ninety-three of 217 members of a self-help group for sufferers from obsessive-compulsive disorder (OCD) completed a detailed questionnaire concerning psychological symptoms, biographical data, and the family and social context of their disorder. Eighty-one respondents (49 women) met DSM-III-R criteria for OCD, and the data are based on these. The mean duration of OCD was 18 years, and 74% of respondents rated their symptoms as extremely, very, or fairly severe for at least 50% of the time since onset. Respondents had received a great deal of psychiatric and psychological treatment, and rated behaviour therapy and individual psychotherapy as the most effective. Women employed outside the home reported significantly less obsessional symptoms than those who were not. Significantly raised scores on a measure of perceived parental protection, and significant correlations between parental overprotection and the amount of psychiatric treatment, suggest avenues for new research in the area.

Adult↗

Psychological status of morbidly obese women before gastric restriction surgery.

One hundred and eighteen of 142 morbidly obese women had gastric restriction surgery after completing self-report questionnaire measures of psychosocial adjustment as part of their preoperative psychiatric assessment. Compared with an age-matched normal population, they scored significantly higher on measures of phobic anxiety, somatization, depression, hostility, and marital dissatisfaction, the last being associated mainly with later onset obesity. Factor analysis of questionnaire and weight data showed that weight was largely independent of psychological adjustment, although associations occurred when analysis was restricted to the data on married women, in which marital and self-assertion abnormalities loaded significantly on the same factor.

Adaptation, Psychological↗

Agoraphobia and parental bereavement.

The prevalence of parental bereavement was determined in 50 married female outpatients with a DSM-III diagnosis of agoraphobia and in a control group of married female outpatients diagnosed as having non-psychotic psychiatric disorders other than agoraphobia. The two groups were matched for age and overall severity of psychiatric symptoms. Compared with the general population, the patient control group reported a statistically significant excess of parental, but not maternal, bereavement. The agoraphobic group was significantly younger than the control group at the time of parental loss. These data, together with other reports, suggest a contribution of paternal bereavement before the age of 30 years to agoraphobia in married women and a contribution of recent parental bereavement ot psychiatric disorder in general.

Adult↗