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Biomedical subjects

R J HUEBNER

Publications and source records attributed to R J HUEBNER.

At least 19 recordsLinked to original sources
PubMed1965

RUBELLA COMPLEMENT FIXATION TEST.

Complement-fixing antigens specific for rubella were made in tissue cultures of RK-13 rabbit kidney cells and primary cultures of kidney from the African green monkey. The antigens were prepared with the infected cell monolayer diluted to 30 percent with supernatant fluid and frozen and thawed three times. Complement-fixing antibody appeared in patients with rubella soon after the termination of rash and persisted for at least 8 months. In 8 out of 12 individuals who had the disease 10 to 20 years before they were tested, no complement-fixing antibody was found, but neutralizing antibody was present.

Animals↗
PubMed1964

COMPLEMENT-FIXING ANTIGENS IN TISSUE CULTURES OF AVIAN LEUCOSIS VIRUSES.

Avian sarcoma and leucosis virus preparations grown in chick embryo tissue cultures contained complement-fixing antigens, which were demonstrated with the use of antiserums from hamsters carrying sarcomas induced by the Schmidt-Ruppin strain of avian sarcoma virus. The complement-fixing antigens shared by three different strains of avian leucosis and one strain of avian sarcoma viruses were largely "soluble" (having failed to sediment when centrifuged at 59,364g for 70 minutes). Sedimented particles, presumably virus particles, contained the common sarcoma-leucosis antigen as well.

Animals↗
PubMed1963

INHIBITION BY 5-IODODEOXYURIDINE OF THE ONCOGENIC EFFECTS OF ADENOVIRUS TYPE 12 IN HAMSTERS.

Subcutaneous tumors induced in newborn hamsters by type 12 adenovirus were suppressed when 0.5 mg of 5-iodo-2'-deoxyuridine (IUdR) was given at the same subcutaneous site as the virus. Although one injection of IUdR given immediately after the virus was effective, additional injections on subsequent days reduced further the number of hamsters developing tumors. These effects of lUdR are especially interesting since replication of infectious adenovirus 12 cannot be demonstrated in the hamsters at any time before or after tumor development.

Adenoviridae↗
PubMed1963

RUBELLA VIRUS: NEUTRALIZING ANTIBODY IN COMMERCIAL GAMMA GLOBULIN.

In 19 lots of standard commercial gamma globulin from humans, the titers of antibody neutralizing rubella virus varied from, 256 to 2048. The titers could not be correlated with geographic location of the donors, method of extraction, or tissue source. Samples of gamma globulin from rubella convalescents had titers of 4096. These titers were approximately 20 times higher than those in serum specimens from patients ill with natural or experimental infection. Serum antibody appears to persist for a number of years at nearly the original titers.

Animals↗