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Biomedical subjects

R J Grieve

Publications and source records attributed to R J Grieve.

28 records · Page 2Linked to original sources
PubMed1979

Exercise responses of healthy subjects in the evaluation of cardioselectivity of beta-blockers.

The effects of intravenous propranolol, metoprolol, acebutolol and placebo on exercise-induced changes in heart rate and peak flow rate (PFR) have been studied in a group of healthy subjects. The three beta-blockers produced significant and comparable reductions in exercise-induced tachycardia and the magnitude of the reduction was related to the log plasma concentration of each drug. Significant cardiac beta-blockade was detectable for three hours after giving propranolol and for four hours after metoprolol and acebutolol. The exercise-induced changes in PFR were small and variable and were not significantly affected by any of the drugs. We conclude that, contrary to published reports, exercise-induced changes in heart rate and PFR in healthy subjects do not provide a satisfactory test system for assessing the selectivity of beta-blockers.

Adrenergic beta-Antagonists↗
PubMed1979

Tumour markers in breast cancer.

The clinical usefulness of 8 potential tumour markers has been evaluated in 69 patients with Stage I and II breast cancer and 57 patients with Stage III and IV. Serum CEA concentrations were raised in 13% of patients with local and 65% of those with advanced breast cancer. In patients with clinical evidence of progression or regression of tumour, serum CEA levels changed appropriately in 83% of cases. Taking 4 of the markers (carcinoembryonic antigen (CEA), lactalbumin, alpha subunit and haptoglobin) serum concentrations of one or more were raised in 33% of patients with local disease and 81% of those with advanced breast cancer. However, marker concentrations were often only marginally raised, and are unlikely to provide sensitive guide to tumour burden. CEA, lactalbumin and alpha subunit were detectable in 68%, 43% and 40% respectively of extracts of primary breast cancers.

Breast Neoplasms↗
PubMed1977

Distribution of various coronary risk factors in an urban general practice.

Seven hundred and fifty asymptomatic European subjects aged 16 to 69 years from an urban general practice were screened for various coronary risk factors. Required information was completed for 98.9 percent of the total sample. The incidence of individual risk factors in males and females respectively were: smoking, 52.8 percent and 45.6 percent; obesity, 26.9 percent and 30.9 percent; definite hypertension, 5.6 percent and 4.0 percent; borderline hypertension, 5.3 percent and 5.1 percent; hyperlipidaemia, 12.8 percent and 8.0 percent; impaired glucose tolerance, 1.1 percent and 1.3 percent. Respective figures for males and females with regard to numbers of risk factors present were: one or more risks present, 68.5 percent and 66.9 percent; two or more, 26.5 percent and 23.5 percent; three or more, 8.0 percent and 4.5 percent; four risk factors present, 1.6 percent and 0.3 percent.

Adolescent↗