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Biomedical subjects

R J Graff

Publications and source records attributed to R J Graff.

At least 37 records · Page 2Linked to original sources
PubMed1976

Serum lactic dehydrogenase and irreversible renal allograft rejection.

The relationship between serum lactic dehydrogenase (SLDH) values and renal allograft rejection was examined in the dog and in man. Nine dogs with renal allografts and four with autografts had similar maximal elevations of SLDH during the first five postoperative days (mean, 420 +/- 213 and 433 +/- 80 I.U. per liter, respectively). During rejection of the allografts between days 7 and 14 the maximum SLDH was 810 +/- 285 I.U. per liter, and in autografts the peak SLDH was 233 +/- 22 I.U. per liter (p less than 0.01). The isoenzyme pattern of maximum SLDH during rejection was prominent in LDH5 and corresponded with renal tissue LDH isoenzyme composition. In 93 episodes of initial acute human renal allograft rejection reactions, the SLDH peaked above 500 I.U. per liter in 23 cases and remained below 500 I.U. per liter in 70 cases. SLDH levels above 500 I.U. per liter were associated with complete rejection of the kidney in 91 percent of patients and SLDH levels persistently below 500 I.U. per liter corresponded with reversal of rejection reaction in 99 percent of patients (p less than 0.01). Marked SLDH elevation is associated with severe, usually complete renal allograft rejection and may be useful in identifying patients with irreversible rejection reactions.

Animals↗
PubMed1975

Saphenous vein-popliteal artery fistula for chornic hemodialysis.

A saphenous vein arteriovenous fistula for chronic hemodialysis can be formed in the thigh by tunneling the vein subcutaneously, anastomosing the distal end to the popliteal artery, and leaving the proximal end attached to the femoral vein. Of seven fistulas, only one has thrombosed spontaneously. There were no instances of infection, vascular insufficiency, or high output cardiac failure. A saphenous vein-popliteal artery fistula can be a satisfactory method of maintaining vascular access in those patients who require chronic hemodialysis but who have no available sites in the upper extremities for construction of a fistula.

Arteriovenous Shunt, Surgical↗
PubMed1975

Marked histoincompatibility between and within sublines of AKR mice used in a syngeneic leukemia model.

Sublines of AKR mice differed significantly in their histoincompatibility to AKR/J mice, as indicated by their ability to reject AKR/J skin grafts and an AKR transplantable leukemia. Further, all sublines tested demonstrated some degree of heterogeneity, because isografts were rejected in 5-97% of the mice, depending on the subline. The presence of excessive heterogeneity among and within sublines poses a serious problem for experimental oncologists using these sublines in their tumor models.

Animals↗
PubMed1972

Myeloma proteins as tumor-specific transplantation antigens.

BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.

Animals↗