Search PubMed⌕ Search

Biomedical subjects

R J Genco

Publications and source records attributed to R J Genco.

284 records · Page 16Linked to original sources
PubMedDate not supplied

Antigens released from four oral bacteria in periodontitis.

Antigens fractionated from cultures of four oral bacteria were tested for binding of serum IgG, IgA and IgM from patients in early and established phase of periodontitis. Bacteroides gingivalis and A.actinomycetemcomitans released antigens that discriminated between serum from individuals with or without periodontitis. The discriminating antigens ranged from 10 to 43 kDa and included neutral sugar and protein but no lipids. Significantly increased levels of IgG and IgA antibodies to the antigens released from B. gingivalis were detected before bone loss was seen and predicted such disease progression.

Actinobacillus↗
PubMedDate not supplied

The role of antibody, complement and neutrophils in host defense against Actinobacillus actinomycetemcomitans.

A. actinomycetemcomitans is a facultative Gram-negative coccobacillus which has been implicated in the etiology and pathogenesis of localized juvenile periodontitis and has also been recognized for its potential to cause serious extraoral infections, particularly endocarditis. The polymorphonuclear neutrophil has been suggested to play a key role in host resistance to periodontopathic organisms, as indicated by the association between defective production or function of these phagocytic cells and severe periodontal disease. This association has engendered interest in the study of the interaction between neutrophils and A. actinomycetemcomitans, as well as the role of immunoglobulin and complement in facilitating this interaction. The objective of this review is to summarize current knowledge of the nature and consequences of the interaction between A. actinomycetemcomitans and the host defense triad consisting of neutrophils, complement and immunoglobulin.

Actinobacillus↗
PubMedDate not supplied

New horizons in periodontics. The challenge for diagnosis.

Contemporary periodontics offers successful treatment for most cases of periodontitis. The data analyzed in this paper suggest, however, that a large percentage of the population in our region suffers from established, overt periodontitis and does not receive periodontal therapy. Guidelines and the sensitivity and specificity of detection, using present-day clinical procedures of periodontal pocket probing and radiograph analysis, are described for the detection of patients with established, overt periodontitis.

Adult↗
PubMedDate not supplied

Identification of Bacteroides gingivalis by fluorescent antibody staining.

Reactivity with the conjugates to the 4 serogroups A, B, C and C-1 of the former taxon Bacteroides melaninogenicus and with antisera to B. gingivalis and to oral strains of B. melaninogenicus subsp. intermedius, was studied by fluorescent antibody staining (FAS) on strains representative of the black-pigmented Bacteroides: B. asaccharolyticus, B. melaningogenicus subsp. intermedius, B. melaninogenicus subsp. melaninogenicus, B. melaninogenicus subsp. levii, B. melaninogenicus subsp. macacae and B. gingivalis. The strains of B. gingivalis only reacted with the homologous antiserum and failed to react with any of the other immunoreagents tested indicating that the oral strains of asaccharolytic black- pigmented Bacteroides belong to a serogroup distinct from those currently serogrouped. This serological characteristic corroborates the definition of the new species B. gingivalis which has been proposed on the basis of phenotypic and genetic characteristics different from that of B. asaccharolyticus and can be used for their discrimination. FAS appears to be a reliable method for identification of B. gingivalis, a suspected major periodontopathic organism.

Bacteroides↗