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Biomedical subjects

R J Friedman

Publications and source records attributed to R J Friedman.

188 records · Page 11Linked to original sources
PubMedDate not supplied

A standardized method for assessment of elbow function. Research Committee, American Shoulder and Elbow Surgeons.

The American Shoulder and Elbow Surgeons have adopted a standardized form for assessment of the elbow. This form was developed by the Research Committee of the American Shoulder and Elbow Surgeons and subsequently adopted by the membership. The patient self-evaluation section contains visual analog scales for pain and a series of questions relating to function of the extremity. The responses to the questions are scored on a 4-point ordinal scale. The physician assessment section has 4 parts: motion, stability, strength, and physical findings. It is hoped that adoption of this method of data collection will stimulate multicenter studies and improve communication between professionals who assess and treat patients with elbow disorders.

Activities of Daily Living↗
PubMedDate not supplied

Complete brachial plexus palsy after total shoulder arthroplasty done with interscalene block anesthesia.

BACKGROUND AND OBJECTIVES: This report illustrates that brachial plexus palsy can result from either interscalene block or total shoulder arthroplasty. It is often impossible to determine which procedure caused the deficit; therefore, we believe the focus should be placed on treatment of the neurologic deficit. This report provides a suggested algorithm for diagnosis and treatment of postprocedure brachial plexus palsy. METHODS: Interscalene block was used as the operative anesthetic for our patient's total shoulder arthroplasty. Complete brachial plexus palsy was diagnosed postoperatively. RESULTS: The patient's postoperative treatment and recovery are described. CONCLUSIONS: Proper diagnosis and treatment of postprocedure brachial plexus palsy may improve recovery of function. Several precautions may reduce the likelihood of brachial plexus palsy following interscalene block for total shoulder arthroplasty.

Adult↗
PubMedDate not supplied

Hydroxyapatite composites designed for antibiotic drug delivery and bone reconstruction: a caprine model.

The purpose of this study was to investigate the feasibility of fabricating a drug delivery system that serves a dual function, to eradicate infection as well as to provide a scaffold for osseous integration. Two porous composite systems were fabricated using hydroxyapatite (HA) as the carrier for gentamicin sulfate (GS), an aminoglycoside antibiotic. Structural and mechanical properties of porous HA-GS composites were characterized and the in vitro release behavior of GS from fabricated composites was monitored and compared with the well-known polymethylmethacrylate (PMMA)-GS delivery system. Scanning electron microscopy revealed a macropore range of 150 to 200 microm and 100 to 190 microm for the sintered and unsintered HA-GS composites, respectively. The effect of GS inclusion on bone apposition and ingrowth was assessed using a caprine model. Plugs 10 mm x 6 mm of cylindrical tricalcium phosphate, sintered HA, and sintered HA-GS were implanted in the femoral diaphysis for a period of 6 weeks. Data collected during the in vitro study showed that GS can successfully be incorporated into HA and used as a drug delivery system to eradicate Staphylococcus aureus. In vivo data confirmed that the inclusion of GS within a ceramic matrix did not stimulate or inhibit osteointegration or bone apposition. In conclusion, the fabricated sintered HA-GS composite may be beneficial in the treatment of infected osseous sites as a drug delivery system.

Animals↗
PubMedDate not supplied

Kinematic MRI of the shoulder.

OBJECTIVE: Clinical evaluation of shoulder pain can be difficult. Pain in the shoulder is often dynamic/positional, and it can often be elicited only during specific activity or function. Soft tissue deforms or changes in shape through motion. These complex interrelationships at the glenoid humeral joint require dynamic studies to accurately evaluate normal anatomy and abnormal pathology. The objective of our study was to evaluate the use of a dynamic cyclic cine imaging to evaluate the glenoid humeral joint. MATERIALS AND METHODS: Kinematic MRI was performed using axial 5 mm sections of the gradient echo and dedicated shoulder surface coil. The patient's arm was placed in the Bonutti cine shoulder system and allowed fixed incremental rotational movement of the shoulder at 10 degrees intervals. Images were reformatted onto a dynamic cine motion by oscillating from internal to external rotation then back to internal rotation. A total of 24 asymptomatic shoulders and 35 symptomatic painful shoulders were studied. RESULTS: Normal variations in the glenoid labrum were readily identified. The glenoid labrum in external rotation is taunt and triangular with well-identified capsular attachments. In neutral rotation the labrum often has increased signal and the middle glenoid humeral ligament occasionally blends with the labrum, making identification difficult. In maximum internal rotation the labrum is rounded and occasionally infolded. Variations in signal through the labrum are not indicative of tears. Capsular attachment must be followed from maximum internal to external rotation to identify stripping. The middle and inferior glenoid humeral ligaments often blend with labrum and internal rotation; however, in external rotation they can be identified as distinct and separate structures. Subcoracoid impingement can be identified in maximum internal rotation with a narrowing of the subcoracoid space to < 11 mm and buckling of the subscapularis and lesser tuberosity against the coracoid process. CONCLUSION: Accurate evaluation of the capsular/labral complex requires cine studies for accurate diagnosis. Signal changes alone or labral morphology alone varies through rotation, and static MRI does not accurately assess these morphologic changes, which vary with extremity position. Capsular attachments can be identified with cine studies accurately and reproducibly. Subcoracoid impingement can be identified with a narrowing of the coracohumeral distance to < 11 mm in internal rotation, which is suggestive of pathology.

Humans↗
PubMedDate not supplied

Heel reconstruction with flexor digitorum brevis musculocutaneous flap.

A 4-year-old girl with an extensive soft tissue loss of the left heel is presented. Management by debridement followed by coverage with an innervated flexor digitorum superficialis musculocutaneous flap resulted in primary healing. Full weight-bearing ambulation was resumed 8 weeks postoperatively. The patient has been ambulating on the reconstructed heel for 18 months without difficulty. Technical aspects of the reconstruction are presented as well as a discussion of treatment alternatives.

Child, Preschool↗
PubMedDate not supplied

Animal models of orthopedic implant infection.

Prosthetic infection following total joint replacement can have catastrophic results both physically and psychologically for patients, leading to complete failure of the arthroplasty, possible amputation, prolonged hospitalization, and even death. Although with the use of prophylactic antibiotics and greatly improved operating room techniques the infection rate has decreased markedly during the years, challenges still remain for better preventive and therapeutic measures. In this review the in vivo experimental methods for studies of prosthetic infection are discussed, concentrating on (1) the animal models that have been established and the use of these animal models for studies of pathogenesis of bacteria, behavior of biofilm, effect of biomaterials on prosthetic infection rate, and the effect of infection on biomaterial surfaces, and (2) how to design and conduct an animal model of orthopedic prosthetic infection including animal selection, implant fabrication, bacterial inoculation, surgical technique, and the methods for evaluating the results.

Animals↗
PubMedDate not supplied

Malignant melanoma in the 1990s: the continued importance of early detection and the role of physician examination and self-examination of the skin.

Despite the exciting new techniques being developed to help diagnose early malignant melanoma, the current standard of care remains periodic examination of the skin. The combination of routine physician examination coupled with self-examination of the skin provides an opportunity for the identification of early malignant melanoma. Removal of such thin lesions can significantly reduce the ever-increasing mortality rate from this potentially serious form of cutaneous cancer.

Humans↗