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Biomedical subjects

R J Cowan

Publications and source records attributed to R J Cowan.

At least 55 records · Page 3Linked to original sources
PubMed1979

Plasmacytoma simulating meningioma on brain scan.

The flow study and static images of the brain scans of two patients with plasmacytoma of the skull were identical to the pattern most commonly seen with meningioma. There was a prominent blush on dynamic imaging which did not wash out combined with an intense uptake on static views adjacent to a meningeal surface. In patients with known multiple myeloma, the diagnosis of plasmacytoma of the skull or cranial cavity should be considered when this characteristic pattern is seen.

Aged↗
PubMed1979

Radionuclide sinography: diagnosis of lateral sinus thrombosis by dynamic and static brain imaging.

Four patients with lateral sinus thrombosis were studied by radionuclide (RN) dynamic studies and RN static brain scans. Findings included: (a) abrupt termination of RN activity in the midportion of a lateral sinus ("stump sign"); (b) nonvisualization on dynamic, increased visualization on static images ipsilateral to a prominent sinus groove on a plain skull radiograph; and (c) increased activity on static images with nonfilling on angiography. RN demonstration of the "stump sign" is pathognomonic of lateral sinus occlusion; the latter two patterns require radiographic demonstration of an ipsilateral sinus groove or angiography for significance.

Adult↗
PubMed1979

Radionuclide scanning in patients with advanced malignant melanoma.

The results of liver, bone, and brain scans in 84 patients with recurrent or metastatic malignant melanoma were reviewed. The liver scan was initially positive in 18% (14/78) and ultimately in 32% (25/78). Serum alkaline phosphatase and lactic dehydrogenase were elevated in 92%. These patients ultimately developed positive liver scans, while convincing hepatomegaly was noted in only 44%. Bone scans were eventually positive in 33% (16/49), all of whom had pain. Brain scans were positive in 15% (10/65), all of whom had CNS symptoms. In asymptomatic patients, bone and brain scans only rarely disclosed occult lesions.

Bone Neoplasms↗
PubMed1977

Localization of 99mTc-Sn-pyrophosphate in left ventricular aneurysms.

Concentration of 99mTc-pyrophosphate (99mTc-PPi) in the area of left ventricular aneurysms is discussed. In three cases clinical, laboratory, and electrocardiographic (ECG) evidence did not indicate that these patients currently had an acute myocardial infarction, but each patient had a clinical history and an ECG picture compatible with an old myocardial infarction. Cardiac catheterization revealed a large left ventricular aneurysm in all three cases. The reason for the preferential uptake of the radionuclide in the area of these aneurysms is not certain at this time.

Diphosphates↗
PubMed1976

Brain scanning in patients with recurrent breast cancer.

Brain scans were performed on 116 patients with recurrent breast cancer. Seventy-eight of 79 (98%) asymptomatic patients with recurrent disease had negative brain scans. Eleven of 37 (30%) patients with central nervous system (CNS) symptoms had scans indicative of intracranial metastases. There was no difference in the distribution of extracranial metastaic disease in patients who had positive brain scans when compared with those who did not. Brain scaning is of value in detecting intracranial metastases in patients with CNS symptoms. Brain scanning seems unnecessary, however, in the staging of patients with recurrent breast cancer who have no CNS symptoms.

Brain Neoplasms↗