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R J Corry

Publications and source records attributed to R J Corry.

At least 127 records · Page 7Linked to original sources
PubMed1983

Factors influencing male sexual impotence after renal transplantation.

Sexual impotence has been reported sixfold after sequential renal transplantation. The effects of race, age, diabetes mellitus, hypertension, uremia, arteriosclerosis (by ABI = ankle BP/brachial BP), penile blood flow (by PBI = penile BP/brachial BP), length of dialysis and transplantation, and patency of hypogastric arteries (by angiogram and operative description) on impotence were examined in a retrospective study of 61 male transplant patients followed from six to 108 months and a prospective study of 15 patients evaluated before and after transplantation with a six-month follow-up. Age (greater than forty years) was the only factor deleterious to male potency (potent patients 40.1 +/- 10.40 years vs impotent patients 48.6 +/- 10.06 years significant at p less than 0.006). Impotence did not correlate with ABI and PBI. Interruption of both hypogastric arteries is not necessarily related to impotence. Vascular impotence is more uncommon in renal transplant recipients than we had anticipated. Post-transplantation male impotence is perhaps best treated by penile prosthesis insertion.

Adolescent↗
PubMed1983

Abrogation of second-set rejection with cyclosporine.

Cyclosporine was evaluated for its ability to delay or prevent accelerated rejection in a model of the second-set immune response. Lewis rats sensitized by LBN skin grafts or subcutaneous heart fragments experienced accelerated rejection of heterotopic, vascularized LBN hearts with a mean survival time (MST) of approximately 5 days versus MST of 9.5 days for primary grafts. A short course of cyclosporine (10 mg/kg/day for 10 days) significantly prolonged graft survival in presensitized hosts to approximately 12 days (P less than 0.01) as compared with the nontreated controls. Adjunctive splenectomy failed to further extend graft survival; MSTs were 12.0 and 5.7 days with and without cyclosporine, respectively. A comparable abrogation of second-set rejection was also achieved with a short course of antithymocyte serum (MST of 10.6 days). Rejection promptly ensued in all of the above groups shortly after cessation of immunosuppression. In contrast, a maintenance regimen of cyclosporine, given in a tapering dose, markedly extended graft survival to from 77 to 100+ days. Again, however, rejection eventually occurred following withdrawal of the cyclosporine. These data suggest that cyclosporine can indeed effectively prolong allograft survival in presensitized hosts.

Animals↗
PubMed1983

The transmission of hepatitis B by renal transplantation.

A case of a renal transplant is reported with hepatitis B infection acquired directly from the cadaveric kidney of a previously unrecognized hepatitis B carrier. In retrospect, the recipient's serum became reactive for the virus 6 days postoperatively which was not recognized for ten weeks thereby placing at risk for secondary transmission almost 100 health care deliverers. Of interest, the other kidney from the same donor caused only antibody conversion in its recipient. This kidney was mechanically perfused prior to implantation while the infected recipient's transplant was cold stored.

Adult↗
PubMed1983

Long-term result of conservative surgical management of the ruptured renal transplant.

Seven instances of spontaneous allograft rupture have been identified in a series of 585 renal transplants. Edema from acute rejection was the only common feature found. Prompt diagnosis and intervention were required to control hemorrhage. Criteria for conservative therapy are presented. The use of mattress sutures buttressed with Teflon pledgets and topical hemostatic agent proved successful in two-thirds of the cases. Nephrectomy was performed in one instance where the graft was grossly infected and in another case where hemorrhage could not be controlled. Five of seven patients have enjoyed long-term normal renal function.

Adolescent↗
PubMed1983

Colorectal perforation in renal transplant recipients.

Of 525 patients who received 585 renal transplants, seven developed colonic perforations from 6 to 27 days post-transplantation. Six were undergoing antirejection therapy at the time of perforation. Prompt diagnosis was made and colonic resection carried out immediately under broad spectrum antibiotic coverage. Primary gastrointestinal reconstruction was performed in one instance and colonic exclusion in the others. One patient died from the insult; three are alive eight to 42 months after perforation; and three succumbed to late unrelated problems at two, three, and 24 months. Early diagnosis, immediate thorough debridement of the peritoneal cavity, and colonic exclusion carry the best prognosis.

Adult↗
PubMed1982

Effect of transfusion of donor on allograft survival.

It has been reported by two European transplant centers that blood transfusion of cadaver donors with third-party blood prior to nephrectomy increases renal allograft survival rates by approximately 30% at 1 year. A retrospective analysis in our center was performed on 293 kidney recipients, 110 of whom received kidneys from untransfused donors. Actuarial analyses revealed no significant differences in graft survival rates between all nontransfused donor kidneys and all transfused donor kidneys. Considering only first transplant recipients, there was no difference in graft survival rates between nontransfused donor kidneys and transfused donor kidneys. In addition, when only preoperatively transfused recipients receiving first transplants were examined, there was no difference in graft survival rates between nontransfused donor kidneys and transfused donor kidneys. Animal studies were performed with (Lewis x Brown Norway)F1 (LBNF1) hybrid rat hearts transplanted heterotopically to the abdomens of Lewis rat recipients. Six LBNF1 heart grafts had a mean survival time of 8.0 +/- 1.1 days. Five LBNF1 rats received 2 ml of heparinized whole blood from Charles River (CD) rats 24 hr before heart transplantation to Lewis recipients. The transfused LBNF1 grafts had a mean survival time of 6.6 +/- 0.9 days. Therefore, donor blood transfusion does not appear to prolong graft survival in this retrospective human study or in the animal model.

Animals↗
PubMed1982

Pelvic hemodynamics and male sexual impotence after renal transplantation.

Sexual impotence has been reported to increase sixfold after sequential renal transplantations. This study examined the effects of age, diabetes mellitus, systemic hypertension, uremia, arteriosclerosis, penile blood flow, and patency of hypogastric arteries on impotence. Sixty-one male transplant patients were followed up from six to 108 months. An age of greater than 40 years was the only factor deleterious to potency (P = .006). Interruption of both hypogastric arteries is not necessarily related to impotence. Post-transplantation male impotence is perhaps best treated by penile prosthesis insertion. A hemodynamic classification is proposed.

Adolescent↗