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Biomedical subjects

R J Cadoret

Publications and source records attributed to R J Cadoret.

At least 55 records · Page 3Linked to original sources
PubMed1980

Depression in family practice: long-term prognosis and somatic complaints.

Somatic pain, functional, and anxiety complaints of 154 depressed patients were followed during the course of their initial depression and were found to parallel the depression: these complaints increased in number just prior to diagnosis of depression and decreased to normal levels after one year's treatment of the depression. Persistence of these types of somatic symptoms after one year's treatment predicted eventual chronicity of the depression. Older patients were also more likely to develop chronic depressions, and there was some indication that those individuals who had an initial remission of a depression followed by a second depression which then became chronic had longer first depressions.

Adolescent↗
PubMed1979

Depression in family practice: changes in pattern of patient visits and complaints during subsequent developing depressions.

This study was done to characterize changes in patient behavior during specific time periods immediately before first, second, third, and fourth episodes of depression. Forty-three patients from a group of 154 depressed patients examined in an earlier study developed 59 subsequent episodes of depression, and these were the patients used in this study. Suitable age and sex matched controls were also examined for the same time periods. The depressed patients and controls were patients in a rural solo practice. The depressed patients showed increased number of patient initiated visits, increased incidence of hospitalization, increased number of functional complaints, increased number of pain complaints, and increased feelings of tension as compared to controls during the seven months prior to the diagnosis date of the first and each succeeding episode of depression. The study results indicate that increased numbers of office visits, functional complaints, pain complaints, and anxiety complaints can be harbingers of a clinical depression, whether it be the index (first) or a subsequent depressive illness.

Depression↗
PubMed1978

Psychopathology in adopted-away offspring of biologic parents with antisocial behavior.

A study of 246 adoptees aged 10 to 37 years separated at birth from biologic parents is used to study genetic heritability of antisocial behavior and to delineate the extent and quality of "antisocial spectrum" conditions. Evidence is presented for a genetic factor in adoptee antisocial behavior and for the following as "spectrum" conditions: (1) hysteria in adult females (Briquet's syndrome) or multiple somatic complaints without medical explanation in younger female subjects and (2) mood swings possibly associated with the symptom of audible thoughts.

Adolescent↗
PubMed1978

Evidence for genetic inheritance of primary affective disorder in adoptees.

Offspring of psychiatrically disturbed and normal biologic parents, adopted away at birth, were followed up as adults. The psychiatric status of the adoptees was determined by adoptive parent and adoptee interviews. The incidence of depression was significantly higher in the affective-parented adoptees (3 depressed of 8 adoptees) than in the remaining adoptees whose biologic parents had other psychiatric conditions or were apparently psychiatrically well (8 depressed of 118). The results suggest a genetic factor in affective disorders.

Adolescent↗
PubMed1978

Depression in primary care: changes in pattern of patient visits and complaints during a developing depression.

The purpose of this study was to characterize changes in patient behavior associated with a developing depression. The records of 154 depressed patients from a solo family practice were examined for type and number of complaints, number of visits, and amount of hospitalization during two periods of time. In addition, 154 patients were used as controls and matched to the depressive patients by age, sex, and season of year seen. Two similar time periods were examined in the controls. The depressed group in comparisons both with itself and with the control group showed, in the seven months prior to the diagnosis of depression, these changes: (1) increase in number of patient-initiated office and home visits; (2) increased incidence of hospitalization; and (3) increased number of presenting complaints of three types: ill-defined "functional" complaints; pain of undetermined etiology in a wide variety of sites: head, chest, abdomen, and extremities; and "nervous" complaints, mainly increased tension and feelings of anxiety. The study results indicate that increased number of office visits and "functional" somatic complaints or anxiety-tension feelings should suggest depression.

Adolescent↗
PubMed1977

Genetic aspects of manic-depressive disease in family practice.

Bipolar affective disorder (manic-depressive disease) is a mental disturbance characterized by phases of both depression and mania. Mania is essential to the diagnosis and is characterized by elevated mood, flight of ideas, and increased psychomotor activity. Current psychiatric literature not only shows that this disease is familial but has also demonstrated, through linkage studies, that an X-linked dominant mode of inheritance adequately explains the strong prevalence of bipolar affective disorder in some families. The family discussed here shows many of the known clinical aspects of bipolar affective disorder. It serves as an example consistent with the X-linked dominant mode of inheritance. Knowledge of the genetic background of this disease aids the family physician by helping to identify members of the family likely to have acquired this condition. The family physician can then look for future problems in them and in their offspring, leading to earlier diagnosis and more effective management. Thus, a member of a bipolar family with supposed unipolar illness (depression only) might be better served with the prophylactic use of lithium carbonate because of his likelihood of possessing a bipolar genotype. The prophylactic use of this drug has been shown effective in reducing the frequency, duration, and intensity of both manic and depressive mood swings.

Adult↗
PubMed1976

Studies of adoptees from psychiatrically disturbed biological parents. III. Medical symptoms and illnesses in childhood and adolescence.

Analysis of data gathered from interviews with adoptive parents supports the hypothesis that female adoptees of antisocial biological backgrounds might have higher percentages of somatic symptoms. The authors compared female adoptees of antisocial parentage with male and female controls, male adoptees of antisocial parentage, and male and female adoptees whose biological parents had other psychiatric conditions. They stress the importance of this hypothesis in the diagnosis and management of childhood and adolescent "medical" and behavioral problems.

Adolescent↗
PubMed1975

Studies of adoptees from psychiatrically disturbed biologic parents. II. Temperament, hyperactive, antisocial, and developmental variables.

Temperament, hyperactivity, antisocial behavior, and developmental milestones were assessed in two groups of adoptees by interviewing the adoptive parents. One group, the "experimental," was born of psychiatrically disturbed biologic parents (N = 59). The second group, the "control," had psychiatrically "normal" parents (N = 54). Infants in each group were separated from their biologic parents at birth and had no further contact with them. Male "experimental" adoptees had excess number of temperament traits characteristic of the "difficult" child, as well as an excess of antisocial behaviors when contrasted with male control subjects. No differences between control and experimental females were found for these variables. Hyperactive behavior in the adoptees of each sex was associated more with antisocial parentage than in those of "normal" parentage.

Adolescent↗
PubMed1975

Non-psychotic disorders in the families of process schizophrenics.

The present study was designed to test the hypothesis of "schizophrenic spectrum" disorders. The families of 60 process schizophrenics were systematically interviewed with structured interview forms, and evaluated for psychiatric illness according to strict diagnostic criteria. The interviewed persons were then separated into two groups for comparative analysis according to a positive (FH+) or negative (FH-) family history for schizophrenia. The frequencies of affective disorder and all non-psychotic conditions did not differ to a convincingly significant degree between the two groups. Our data thus fail to support the "schizophrenic spectrum" hypothesis in which neurosis and sociopathy occur as a consequence of a genetic loading for schizophrenia.?

Adult↗
PubMed1975

Studies of adoptees from psychiatrically disturbed biological parents: psychiatric conditions in childhood and adolescence.

Psychiatric problems were assessed in two groups of adoptees by interviewing the adopting parents. One group of 59 adoptees, the "experimental', were born of psychiatrically disturbed biological parents; the other group, the "control' of 54 adoptees, had psychiatrically "normal' biological parents. Both groups had been separated from biological parents at birth. The incidence of psychiatric conditions requiring professional care was significantly higher in the experimental than in the controls (37 per cent vs. 14 per cent). In the experimental group more males than females were disturbed (59 per cent vs. 30 per cent). Most of the excess of disordered males were diagnosed hyperactive. There was some evidence of correlation of the type of psychiatric diagnosis of the biological parent with that of the adoptee.

Adolescent↗