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Biomedical subjects

R J Brown

Publications and source records attributed to R J Brown.

At least 127 records · Page 7Linked to original sources

Multivariate analyses of anthropometric and psychometric variables in probands with affective disorders and their families.

Data on 121 subjects, probands with affective disorders, their spouses and first degree relatives, are analyzed by multivariate methods to determine the relationships between physical types and propensity to illness. 56 variables are used: 39 anthropometric measures, age, sex, and 15 psychometric scales. In a canonical analysis between the anthropometric measures and the psychiatric scales, each canonical variable is found to be largely identified with a single psychometric component, as found in a principal components analysis of the psychometric scales. The two major anthropometric components, size and linearity, do not have any clear relationship with the psychometric components. However, a discriminant analysis that takes each individual as being in one of four clinical groups, normal, unipolar depressed, bipolar affective disorder or other, indicates a clear relationship between the anthropometric measures and mental illness; wide face and deep chest are associated with patients who have bipolar affective disorder. Half of the variables studied are sufficient to give virtually the same amount of discrimination as all 56 variables.

Affective Symptoms↗

Renal fibrosarcoma in the northern fur seal.

A 2-week-old northern fur seal female pup (Callorhinus ursinus) found dead in the Pribilof Islands had an irregular mass at the anterior pole of the right kidney. Histopathological examination revealed a fibrosarcoma.

Animals↗

Quantitative in vitro vasoactivity of 5-hydroxytryptamine on the human basilar artery.

The importance of autacoidal substances in the genesis of cerebral vascular constriction and spasm is an unresolved issue. Comparative vasoactivity of 5-hydroxytryptamine (5HT) and norepinephrine (NE) on the human basilar artery was quantitatively assessed in vitro. 5HT was decidedly more vasoactive in this preparation. Three patterns of vasoactivity were noted with 5HT. Type I was an immediate sustained increase in tension lasting more than 30 minutes. Average increase in tension was 2988 mg (range 120-8600). Type II consisted of a sharp immediate increase in tension to average 1555 mg (range 240-4500) followed by gradual dissipation to base-line levels within 15 minutes. Type III pattern was a lesser immediate increase (372 mg; range 100-850) and more rapid dissipation over ten minutes. NE-induced Type I and Type III activity was present in only six of 20 segments. This study demonstrates that 5HT is vasoactive in human cerebral arteries. Type I sustained contractions may possibly be implicated in spasm. It is hypothesized that such autacoid-induced contraction may contribute to vascular wall ischemia, necrosis, and irreversible constriction as seen in human vasospasm.

Adult↗