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Biomedical subjects

R J Britten

Publications and source records attributed to R J Britten.

173 records · Page 10Linked to original sources
PubMed1971

Transcription of nonrepeated DNA in neonatal and fetal mice.

The transcription of nonrepeated DNA sequences was measured by hybridization of RNA from neonatal and fetal mice to mouse DNA using three different techniques. The measurements indicate that a large part (about 70%) of the rapidly-labeled fetal RNA is transcribed from nonrepeated DNA sequences. It appears that more than 12% of the single-copy DNA sequences are represented in the RNA of newborn mice.

Animals↗
PubMed1966

Nucleotide sequence repetition: a rapidly reassociating fraction of mouse DNA.

The separated complemnentary strands of a minor component in mouse DNA reassociate with each other much more rapidly than do the complementary strands of other DNA's including those of the principal part of mouse DNA. This difference in capacity of the strands to reassociate can be used to effect a preparative separation of the minor component from the principal fraction. The rate constant for reassociation of the minor component, compared with those of viral and bacterial DNA's, indicates that the minor component consists of a short nucleotide sequence present in about one million copies.

Amino Acid Sequence↗
PubMedDate not supplied

Lipopolysaccharide activates the sea urchin immune system.

Profilin is a small, actin-binding protein that functions at the intersection of signal transduction and cytoskeletal modifications. Increases in the number of profilin messages per cell correlate with sea urchin coelomocytes activation in response to injury. Here we show that coelomocytes respond to immune challenge from lipopolysaccharide with significant elevations in profilin transcripts per coelomyocyte.

Animals↗