Classification of cutaneous squamous cell carcinoma.
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Carcinoembryonic Antigen↗
Biomedical subjects
R J Barr
Publications and source records attributed to R J Barr.
Microvenular hemangioma.
Ten examples of a distinctive vascular tumor are reported. These benign acquired lesions typically occur as small, enlarging lesions that favor the extremities, particularly the forearms, of young to middle-aged adults. Clinically, they are purple to red lesions generally thought to be hemangiomas. Histologically, there is a pattern of irregular, branching venules with inconspicuous lumina and lack of cellular atypia. Because the lesions do not conform to existing classifications of vascular tumors, they have been designated with the histologically descriptive name of microvenular hemangioma. Although speculative, they are felt to represent a form of acquired venous hemangioma.
Adolescent↗
Histologic atypia in clinically benign nevi. A prospective study.
Histologic features of dysplastic nevi include varying degrees of pattern atypia, cytologic atypia, and host response. The purpose of this prospective study was to determine the prevalence of these histologic features in benign acquired nevi. Fifty-eight junctional and compound nevi from 26 volunteer subjects were excised and examined. All nevi met each of the following criteria: 5 mm or less in diameter, symmetric, round or slightly oval, uniform pigmentation, distinct and regular margins, and no erythema. One or more of the histologic features associated with dysplastic nevi were present in 87.8% of the lesions; two or more were present in 69%; and all three histologic features were found in 29.3%. These results indicate that histologic features of dysplastic nevi occur in benign common acquired nevi.
Adult↗
Cellular angiolipoma.
Three examples of cellular angiolipoma are presented. They occurred as part of multiple, occasionally painful, subcutaneous nodules on the extremities and trunk of healthy men. There was no familial tendency. Grossly, the cellular angiolipomas were small lesions, approximately 1 cm. Histologically, dense cellular angiomatous tissue comprised more than 95% of the lesions. Much of this component contained prominent spindle cells. Lesser degrees of involvement in the other subcutaneous nodules illustrated the continuum of histology between cellular angiolipomas and more typical angiolipomas. The differential diagnosis of cellular angiolipomas includes spindle cell lipoma, Kaposi's sarcoma, and other vascular tumors. The most important distinguishing features are encapsulation, intravascular fibrin thrombi, septation, association with other more typical angiolipomas, and occurrence in healthy individuals.
Adult↗
Bannayan-Zonana syndrome associated with lymphangiomyomatous lesions.
Bannayan-Zonana syndrome is an autosomal dominant condition that has not been well described in the dermatology literature. The typical case is characterized by macrocephaly, multiple angiomas, and multiple encapsulated or infiltrating lipomas. As in other autosomal dominant hamartoneoplastic syndromes, the degree of expression within one family frequently varies widely. Our patient had macrocephaly and angiomas, as well as lipomas with peculiar histologic features similar to lymphangiomyomas. Her father had a large nevus flameus on his leg, and lipomas with normal histologic appearance. The paternal grandfather had multiple encapsulated lipomas with normal histologic appearance. Neither father nor grandfather had macrocephaly.
Angiokeratoma↗
Dermal thymus. A light microscopic and immunohistochemical study.
Two rare cases of distinctive thymic remnants occurring in the skin are described. The lesions were present at birth, and involved the side of the neck. One child had a complete cleft lip and palate. The other had multiple congenital anomalies consistent with a rare syndrome entitled branchio-oculo-facial syndrome. Microscopically, lobular foci were present in the dermis and consistent with both prethymic and thymic remnants. Immunohistochemical studies using antibodies to T cells and B cells showed a distribution similar to that seen in normal thymus. Dermal thymus appears to be a distinct entity and may be associated with other faciobranchial defects.
Abnormalities, Multiple↗
Idiopathic multicentric osteolysis: report of two new cases and a review of the literature.
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Genes, Dominant↗
Linear granuloma annulare.
Granuloma annulare is a benign dermatosis with multiple clinical presentations and a common histologic picture, which is characterized by areas of degenerated collagen surrounded by palisading histiocytes. A case of granuloma annulare that presented as progressive, asymptomatic, symmetric truncal bands is described. The varied clinical presentations and possible pathogenetic mechanisms of granuloma annulare are reviewed.
Granuloma↗
Subcutaneous myospherulosis.
Myospherulosis is an uncommon subcutaneous disorder believed initially to be caused by an endosporulating fungus. Recently investigators have disproved an infectious cause and have shown that the disease represents an alteration in red blood cells, usually produced by petrolatum or lanolin, with an accompanying foreign-body-type response. We report the case of a 57-year-old woman who had received a penicillin injection approximately 40 years before she developed a cystic mass in the right buttock. Examination of the mass revealed the classic histologic findings of this disease.
Buttocks↗
Topical cyclosporine: effects on allergic contact dermatitis in guinea pigs.
Cyclosporine (CSA) is an effective immunosuppressive agent and is used in tissue transplantation. The present investigation was undertaken to determine the effect of topical delivery of CSA on allergic contact dermatitis in guinea pigs. Topical 15% CSA in an azone (1-dodecylazacycloheptan-2-one)-containing vehicle blocked local elicitation in previously dinitrochlorobenzene (DNCB) sensitized animals that received a single topical application just prior to elicitation. Elicitation was not blocked at a distant site, indicating a local effect of topical CSA. In contrast, topical CSA when applied twice daily for a total of 5 applications during sensitization only, did not block subsequent elicitation. These experiments suggest that cyclosporine may be beneficial in the therapy of human contact dermatitis, as well as other T cell mediated dermatoses.
Administration, Topical↗
Neurofollicular hamartoma: a light microscopic and immunohistochemical study.
Neurofollicular hamartoma is an unusual, previously undescribed neoplasm characterized by a proliferation of spindle cells and hyperplastic pilosebaceous units. Five cases were reviewed. The lesions presented as single, asymptomatic, smooth, flesh-colored papules. Four were on the nose, and one on the adjacent nasolabial fold. Immunoperoxidase studies performed on two cases utilizing antibodies to S-100 antigen were positive in both. These lesions share some histological and clinical features with angiofibroma and neurofibroma.
Adult↗
The orthopaedic consequences of civil disturbance in Northern Ireland.
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Blast Injuries↗
Familial expansile osteolysis.
Familial expansile osteolysis (FEO) is a unique bone dysplasia, which has, over five generations, affected 42 members of a Northern Ireland family. The disease follows a classic autosomal dominant pattern of inheritance. The condition is distinct enough in its clinical features and natural history to be recognized as a new and unique disease. There are both general and focal skeletal changes, the latter having a predominantly peripheral distribution and an onset from the second decade. Progressive osteoclastic resorption accompanied by medullary expansion leads to severe and painful disabling deformities with a tendency to pathologic fracture. Most affected members of the family have an associated early-onset deafness and loss of dentition as a result of unique middle ear and dental abnormalities. The serum alkaline phosphatase and urinary hydroxyproline are elevated to a variable degree, whereas other biochemical indices are normal. The response of the disease to a therapeutic trial using parenteral dichloro-methylene-diphosphonate (dichloro-MDP) produced an initial rapid biochemical response, which was not sustained.
Bone Diseases, Developmental↗
Identification of differentiation-specific antigens in psoriatic versus normal skin using monoclonal antibodies.
Human cell hybrids derived from fusions between carcinoma (HeLa) and normal epidermal keratinocytes can be used as immunogens to generate monoclonal antibodies against keratinocyte differentiation-specific antigens. We examined the immunofluorescent staining patterns of these monoclonals in normal human and psoriatic (lesional and uninvolved) skin tissue sections. The immunofluorescent staining patterns indicate that the monoclonal antibodies are recognizing a number of different keratinocyte antigens. Three monoclonals (HLK7, HLK3, and HLK20) displayed different immunofluorescent reactivity in these tissues. These new monoclonal antibodies will be useful tools to study the differentiation abnormalities in psoriasis and may serve as a marker of the psoriatic diathesis.
Antibodies, Monoclonal↗
Cervical osteomyelitis after rigid oesophagoscopy: brief report.
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Acute Disease↗
A model of human melanoma in cyclosporine-immunosuppressed rats.
A human malignant melanoma maintained in athymic nude mice has been successfully implanted and grown in cyclosporine (Cys)-immunosuppressed Lewis rats. Suspended melanoma cells (10(6)) or solid tumor sections measuring 2-4 mm in diameter were implanted s.c. in rats receiving parenteral Cys doses of 15-50 mg/kg each day for 1 week, and 3 times per week thereafter. Eighty-five percent of solid tumor sections implanted in animals receiving 25 mg/kg resulted in tumor growth, whereas no tumors grew from cell suspension injection sites. The average maximum tumor growth rate was 2 cm3/day, with a doubling time of 8 days. Tumors retained pretransplant gross and microscopic morphology, karyotype, and labeling index. Possible advantages of this model over the athymic nude mouse include greater longevity, larger animal and tumor size, and less stringent aseptic environmental requirements. This model may prove useful for further study of the pathophysiology of melanoma and for testing of new antimelanoma therapies.
Animals↗
Vascular injury associated with low-velocity dislocations of the knee.
Complete dislocation of the knee is a relatively rare condition. When it occurs as a result of high-velocity injury, such as in a road traffic accident, associated vascular injury is generally suspected. In low-velocity injuries, however, distal pulses are often maintained throughout, and the possibility of vascular injury may erroneously be discounted. We report four cases of low-velocity dislocation of the knee, only one of which had an overt vascular disruption, but three of which had arterial damage. On the basis of our experiences, we recommend arteriography in all cases of complete dislocation of the knee.
Accidental Falls↗
Syringomatous hyperplasia and eccrine squamous syringometaplasia associated with benoxaprofen therapy.
Two patients are described, each of whom developed multiple eruptive lesions on sun-exposed areas within days after starting benoxaprofen therapy. The lesions were 2- to 5-mm papules suggestive of syringomas, and microscopically showed squamous metaplasia of eccrine ducts and focal necrosis of eccrine keratinocytes as well as prominent eccrine hyperplasia. In both cases, the lesions resolved completely after benoxaprofen therapy was discontinued. A theoretical basis for these findings is discussed.
Adenoma↗