In imipramine and amitriptyline poisoning the electrocardiographic abnormalities comprise arrhythmias, widening of the QRS complex, and marked changes in die S-T segment. These features were found to be of value in the differential diagnosis of unknown poisoning. The unusual configuration of qR with raised S-T segment in V1, simulating myocardial infarction, was seen in one of our patients and has been noted in four cases reported by other workers.

Adolescent↗

PubMed1968

Rupture of sinus of Valsalva.

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Adult↗

PubMed1967

Non-volatile organic acids of grasses.

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Acids↗

PubMedDate not supplied

Single- versus multiple-dose comparative trial of desipramine hydrochloride: a double-placebo method.

In a double-blind comparative trial utilizing the double-placebo method, depressed neurotic patients whose effective titrated dose of desipramine hydrochloride was 75, 100, or 150 mg were maintained, with equal efficacy, on once-a-day or multiple daily dose regimens. The data confirm that the safety of the once-a-day maintenance regimen (as measured by vital signs, laboratory tests, ECGs, and clinical adverse reactions) is comparable to the safety of the multiple daily dose regimen.

Adolescent↗

PubMedDate not supplied

Vertically integrated flows, discharge potential, and the Dupuit-Forchheimer approximation.

We summarize observations made by various researchers regarding the discharge potential, vertically integrated flows, and the Dupuit-Forchheimer approximation. If a regional flow model is formulated in terms of the discharge potential and the boundary conditions can be written in terms of the discharge potential and the boundary discharges, then the discharges are correct throughout the model domain, without embracing any additional simplifying assumptions.

Environmental Monitoring↗