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Biomedical subjects

R J Ancill

Publications and source records attributed to R J Ancill.

At least 55 records · Page 3Linked to original sources
PubMed1974

Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions.

Leucocytes from 38 patients with Crohn's disease were tested for evidence of migration inhibition in the presence of preparations of colon from a patient with this disease. The occurrence of migration inhibition showed a positive correlation with clinically active disease and a negative correlation with immunosuppressive treatment. It was not seen with leucocytes from 12 healthy subjects.

Adult↗
PubMed1974

Mixed-lymphocyte reaction as a measure of immunological competence of lymphocytes from patients with Crohn's disease.

Peripheral blood lymphocytes from 12 patients with Crohn's disease and from a group of normal volunteers have been tested for transformation under stimulation of allogeneic cells in a mixed lymphocyte culture and by phytohaemagglutinin (PHA) in vitro. There was a significant depression of transformation in the mixed lymphocyte culture where lymphocytes from the Crohn's disease patients constituted the responding population. With PHA stimulation, no difference in transformation was seen between the patients and the control group. This is interpreted as indicating a depression in cellular immunity in Crohn's disease.

Adolescent↗
PubMed1974

An evaluation of the rosette inhibition test in Crohn's disease.

Serial rosette inhibition tests were performed on nine patients with Crohn's disease undergoing immunosuppressive therapy in an attempt to estimate the minimum amount of drug necessary to maintain immunosuppression. The rosette inhibition titre was found to be higher in immunosuppressed patients than in normal subjects. However, there was no consistent correlation of the rosette inhibition titre with the degree of activity of the disease. The test is therefore not sufficiently discriminative to be used as a basis on which to control drug dosage.

Adolescent↗
PubMed1972

The pharmacology of the rat ureter in vivo.

1. A method of recording the peristaltic frequency and the rate of transport of fluid (perfusion rate) in the rat ureter in vivo is described.2. Acetylcholine and atropine did not alter ureteral activity. Histamine increased the rate of peristalsis by up to 15% and the rate of perfusion by up to 10%. Low doses of 5-hydroxytryptamine increased peristaltic frequency whereas high doses decreased peristaltic frequency; all doses reduced the rate of perfusion.3. Morphine reduced the rate of perfusion by 5-10% at all dose levels, but only the highest dose used reduced the frequency of ureteral peristalsis.4. (-)-Adrenaline, (-)-noradrenaline and (+/-)-isoprenaline reduced the frequency of peristalsis. The order of potency was isoprenaline>noradrenaline>adrenaline. The response was dose-related and blocked by propranolol, which itself did not affect ureteral activity.

Acetylcholine↗