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Biomedical subjects

R Ishikawa

Publications and source records attributed to R Ishikawa.

82 records · Page 5Linked to original sources
PubMed1981

[Protective effect of fluosol-DA in acute cerebral ischemia (author's transl)].

Fluosol-DA (Perfluorochemical Blood Substitutes) are small particle fluorocarbons suspended in an emulsion and have a high propensity for carrying oxygen and carbon dioxide. Fluosol-DA was investigated for the modification of acute focal cerebral ischemia and compared with mannitol. A total of 36 adult cats was divided into three groups and underwent transorbital microtourniquet ligation of the middle cerebral artery (MCA). Control animals were given intravenous isotonic saline. Animals in the experimental groups were treated with either intravenous Fluosol-DA or Mannitol. All animals were nursed in an oxygen chamber and four cats from each group were sacrificed at 1, 3 and 6 hours after MCA occlusion. The results of macroscopic and histological examination of the brain suggested Fluosol-DA had a remarkable protective effect on acute focal cerebral ischemia which was in keeping with the observed neurological outcome. It is suggested that Fluosol-DA may support flow in the microcirculation and the small particles of Fluosol-DA may be able to reach the area of ischemia via collaterals by decreasing blood viscosity, preventing narrowing of the arteriolar and capillary lumen and increasing the cerebral blood flow.

Acute Disease↗
PubMed1979

The ocular hypertensive response following experimental acid burns in the rabbit eye.

Following application of 50 microliter of 2N hydrochloric acid to the rabbit cornea, the intraocular pressure rapidly increases and remains markedly elevated for up to 3 hr. The initial rapid increase in intraocular pressure appears to be the result of acid-induced shrinkage of the outer collagenous coats of the eye. The sustained rise in intraocular pressure is mediated in part by prostaglandin release. Increased prostaglandin-like activity, determined in the aqueous after an acid burn, was greatly inhibited by pretreatment of rabbits with indomethacin and to a much lesser extent by pretreatment with imidazole. Both indomethacin and imidazole essentially abolished the sustained elevation of intraocular pressure after an acid burn. Analysis of changes in pH and protein level in the aqueous implies that the stimulus for prostaglanding release within the eye is the penetration of hydrogen ions into the aqueous humor, with resultant intraocular trauma.

Animals↗
PubMedDate not supplied

Protective effect of Fluosol-DA in acute cerebral ischemia.

Fluosol-DA (Perfluorochemical Blood Substitutes) are small particle fluorocarbons suspended in an emulsion and have a high propensity for carrying oxygen and carbon dioxide. Fluosol-DA was investigated for the modification of acute focal cerebral ischemia and compared to mannitol. A total of 36 adult cats were divided into 3 groups and had transorbital microtourniquet ligation of the middle cerebral artery (MCA). Control animals were given intravenous isotonic saline. Animals in the experimental groups were treated with either intravenous Fluosol-DA or mannitol. All animals were nursed in an oxygen chamber and 4 cats from each group were sacrificed at 1, 3 and 6 hours after MCA occlusion. The results of macroscopic and histological examination of the brain suggested Fluosol-DA had a definite protective effect on acute focal cerebral ischemia which was in keeping with the observed neurological outcome. It is suggested that Fluosol-DA may support flow in the microcirculation and that the small particles of Fluosol-DA may be able to reach the area of ischemia via collaterals by decreasing blood viscosity, preventing narrowing of the arteriolar and capillary lumen and increasing the cerebral blood flow.

Animals↗