Search PubMed⌕ Search

Biomedical subjects

R Ishii

Publications and source records attributed to R Ishii.

At least 145 records · Page 8Linked to original sources
PubMed1982

Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism.

Of 281 eyes that had had Sato's anterior-posterior radial keratotomy for myopia or myopic astigmatism, 80 (50 patients) underwent follow-up examinations ten to 20 years later. Sixty of the 80 eyes had bullous keratopathy. The onset of this disease occurred when the patient was about 40 years old, regardless of the patient's age at the time of surgery. Seven corneal buttons were obtained from patients with bullous keratopathy who required penetrating keratoplasty. Light and electron microscopy disclosed subepithelial bullae, degenerate or absent Bowman's zone, and thickened Descemet's membrane. Flattened fibroblastic endothelial cells were observed in three of the seven cases. This type of radial keratotomy surgery seems to produce severe corneal decompensation many years later, possibly as a result of damage from the corneal incisions in combination with endothelial losses from aging.

Adolescent↗
PubMed1981

[Effect of hydrogenated ergot alkaloids on cerebral metabolism of the patients with neurological deficits after subarachnoid hemorrhage (author's transl)].

Cerebral blood flow and metabolism were measured in 9 patients with neurological deficits after subarachnoid hemorrhage using the 133Xe intra carotid injection methods. Regional cerebral blood flow (r-CBF) values were calculated with initial slope method (2 minutes flow index), their values were compared with the blood flow response to arterial PCO2 and to administration of hydrogenated ergot alkaloids (HEA). In case of repeated examination after short interval CBF values were corrected using the rate of reproducibility. The content of oxygen, glucose, lactate, and pyruvate in the arterial and the internal jugular blood were measured , and CMRO2, CMR glucose, CMR lactate, values were calculated: 1st step: The measurement of r-CBF was performed immediately after the infusion of 1.5 mg HEA for 15 minutes. The focal ischemic lesions decreased, mean CBF value increased by 8% significantly, arterio-venous difference of oxygen value increased by 20% significantly and CMRO2 value increased by 26% significantly after HEA administration. 2nd step: 1.8 mg HEA was infused for one week. EEG findings were improved after administration of HEA. The pressure and the lactate levels of cerebrospinal fluid decreased, but the effect of HEA must be carefully distinguished from natural recovery. Administration of HEA increased the CMRO2 values and consequently increased the mean CBF values.

Adult↗
PubMed1979

Regional cerebral blood flow in patients with ruptured intracranial aneurysms.

Eighty-five studies of regional cerebral blood flow (rCBF) were performed on 49 patients with ruptured intracranial aneurysms. The changes in rCBF were analyzed under various pathophysiological conditions, The degree of flow abnormalities correlated well with the clinical severity of neurological deficits. All of the patients with diffuse vasospasm of severe grade, to less than half of their control value, showed focal areas of decreased flow below 30 ml/100 gm/min, in addition to a reduction in mean CBF. The relief or disappearance of vasospasm in angiograms was followed by the increase of rCBF in the ischemic focus and mean CBF. Marked reduction in rCBF was found in patients with intracerebral hematoma and ventricular dilatation. Impaired CO2 response and autoregulation were found in patients with severe neurological deficits, a severe degree of vasospasm and marked depression of CBF. In this series direct operation was delayed in patients with impaired vascular reactivity as well as marked decrease of mean CBF below 30 ml/100 gm/min; good clinical results were obtained in thses patients.

Adult↗