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Biomedical subjects

R Inaba

Publications and source records attributed to R Inaba.

At least 37 records · Page 2Linked to original sources
PubMed1997

Low back pain among different groups of subjects exposed to hand-arm transmitted vibration.

OBJECTIVES: The purpose of this study was to investigate the prevalence of low back pain (LBP) among various groups of subjects exposed to hand-arm transmitted vibration, and to compare the prevalence of LBP of these subjects with that of non-exposed groups. METHODS: The subjects of this study were 13 groups of males and 3 groups of females of working population leaving in a certain city located in the central part of Japan. By means of a questionnaire, interviews, field visits, or annual health examination, information on age, working career, working posture, various types of tools used, and experience of having LBP during the 12 months preceding the completion of the questionnaire were collected. The subjects' age ranged between 22 and 69 years. All subjects were classified into 5 categories, and the prevalence of LBP was obtained for them. RESULTS: On the whole, complaints of LBP among male and female green tea and strawberry farmers were most frequent. There was a large variation (16.0-72.2%) in the prevalence of LBP among subjects operating vibrating tools. Among three groups of health care professionals, the prevalence of LBP was in the range of 36.5-53.0%. The senior doctors had less complaints of LBP. The prevalence of LBP among subjects who had sedentary jobs was in the range of 41.7-45.9%, and almost as high as that in blue-collar workers using vibrating tools. The prevalence of LBP among females exposed to hand-arm transmitted vibration was between 26.1 and 63%. The prevalence rates of LBP among vibration exposed subjects were plotted against the vibration magnitude of tools used by the same subjects reported in our previous study; however, no significant correlation could be obtained between the prevalence of LBP and vibration values. CONCLUSIONS: Exposure to segmental vibration is less likely to be a risk factor in increasing prevalence of LBP. A higher prevalence of LBP in some groups provide strong evidence for a dominant work-related etiology in developing LBP. Regarding data presented in this study and by a review on scientific literature, suggestions for improving working posture were presented. It seemed that to decrease the risk of LBP among these subjects, special attention should be paid to stimulating the adoption of an ergonomic working posture and to ergonomic training.

Adult↗
PubMed1997

Subjective symptoms among motorcycling traffic policemen.

OBJECTIVES: This study investigated the prevalence of subjective symptoms among current and former motorcycling policemen. METHODS: The subjects of this study consisted of 46 current and 72 former motorcycling traffic policemen from a certain city located in the central part of Japan. They were requested to reply to questions on a self-administered questionnaire regarding age, work history, and subjective symptoms (16 items) during the month preceding the completion of the questionnaire. RESULTS: Shoulder stiffness and low-back pain were frequently encountered. On the whole, the prevalence of subjective symptoms was higher among the current motorcycling policemen, even though they were younger. Assessing the prevalence of subjective symptoms by the median value of experience of motorcycle riding revealed that the high-exposure subgroup in the group that currently ride motorcycles had higher prevalence rates for all the symptoms. CONCLUSIONS: The prevalence of subjective symptoms among currently motorcycling traffic policemen seems to be transient, and it declines after the cessation of motorcycle riding or the reallocation to other worktasks, such as office work.

Adult↗
PubMed1997

[CDw90 (Thy-1) expression on CD34 positive cells in peripheral blood stem cell harvest].

In this study, we investigated CDw90 (Thy-1) expression in CD34+ cells and hematopoietic colony-forming ability in purified CD34+ Thy-1+ and CD34+ Thy-1 fractions in the peripheral blood at the PBSCH. The high proliferative potential colony-forming cells (HPP-CFC), which are considered to be more primitive hematopoietic stem cells, were found more frequently in the purified CD34+ Thy-1+ fraction than in the purified CD34+ Thy-1- fraction. Thus, it is useful to decide the optimal time of PBSCH to measure the CD34+ Thy-1+ cells as well as CD34+ cells in the peripheral blood by flow-cytometry. In CD34+ acute myeloblastic leukemia (AML) cells, the co-expression rate of CD34 and Thy-1 was negative, suggesting that it may be possible to estimate the contamination of CD34+ AML cells by the Thy-1 expression rate in CD34+ cells at PBSCH.

Antigens, CD34↗
PubMed1997

[Evaluation of the relation of job stress and food intake to hyperuricemia].

To evaluate the relation of job stress and food intake to hyperuricemia, a case-control study was performed in male subjects who had undergone complete physical examinations. Cases (n = 113) were those with hyperuricemia of over 7.5 mg/dl and controls (n = 113) were those with serum uric acid of less than 7.5 mg/dl. Stepwise regression analysis was performed using sixteen items which were significantly related to hyperuricemia by McNemar's method. Consequently, four items; "negative attitude toward work (Odds ratio 5.22, p < 0.01)", "tendency to become competitive in the job and other areas (Odds ratio 5.54, p < 0.01)" in type A behavior, "high meat consumption (Odds ratio 6.94, p < 0.01)", and "high fat intake (Odds ratio 4.05, p < 0.01)", were significantly related to hyperuricemia.

Adult↗
PubMed1997

[Health conditions and life styles of residential elderly. Part 1. Characteristics and factors related to being healthy elderly persons from a survey of health life style].

A survey was conducted in a highland community of Gifu prefecture on 815 residential elderly persons, over 65 years old, utilizing self-administered questionnaires to study the degree of association between life style factors and health conditions. A total of 718 valid participants (90.6% of the total) were analyzed and cross-examined by applying Breslow's seven health factors, daily behavior factors, physical health consciousness, social mobility factors (13 behavior factors which were determined by the Institute of the Elderly) to determine associations with respondents health conditions. Of the participants, 310 were male and 408 were female with mean ages of 73.8 +/- 6.9 years old and 74.0 +/- 6.9 respectively. The survey results indicated that there were no prominent gender differences over the mobility rate and physical health consciousness among participants. However, it was also found that in the male participants the per person prevalence of past history of illness was higher than in females. In the daily activity analysis, female participants indicated a higher prevalence of difficulty in walking and balance maintenance while ascending and descending stairs. In the general daily activity analysis, male participants had a higher requirement for an aide. In social mobility, male participants recorded a high degree of self-reliance by being physically, socially, and intellectually active and the female participants by fulfilling their social responsibilities. Breslow's seven health indicators were applied and their evaluation points were calculated as 3.9 +/- 1.7 for male participants and 3.5 +/- 1.8 for female participants which showed a significantly higher score for the male participants. The survey also indicated that factors which increase the Breslow score for males, were having a spouse, hobbies, a satisfactory life, a habit of exercising, and non-smoking which in females an appropriate sleeping habit (not less than 7 hours), and working, were the positively related factors.

Activities of Daily Living↗
PubMed1996

[Self-assessed quality of mastication in relation to remaining teeth and self-assessed health status in elderly persons].

To explore factors related to quality of mastication, information about teeth status and self-assessed health status were obtained by a self-administered questionnaire from participants in a dental screening program. Invitation letters for participation in the program were distributed by members of the neighborhood association to 1.275 residents of a town in Gifu prefecture aged 65 years or older. Participation rate in the dental screening program was 40.5%. A total of 513 participants (245 males and 268 females) completed the program and the questionnaire. The results were as follows. 1. Overall, 32% had 20 teeth or more and 88.4% had bridge(s) and/or denture(s). 2. The mean number of remaining teeth were 12.9 for males and 12.5 for females. There was no statistical difference in the number of remaining teeth between males and females. The mean numbers of remaining teeth among those aged 65-69 years was 15.7 and two thirds of them had lost the Lower First Molar. 3. Those who reported to be satisfied with their present mastication were 83.3% of men and 86.3% of women. The proportions were not influenced by age or sex. 4. Quality of mastication was related to self-reported "good physical condition' and "not easily tired'. 5. The proportion of those satisfied with their mastication was large in the groups with remaining teeth index 0-8 and > or = 17, and small in the group with remaining teeth index 9-16, showing a U-shaped curve for satisfaction rate against remaining teeth index. These results suggest a relationship of quality of mastication on health status. The importance of primary dental care for the elderly persons is underlined.

Aged↗
PubMed1995

A synthetic peptide corresponding to a critical intracellular signaling region of the human IL-4 receptor inhibits IL-4-induced proliferation.

We have previously identified a critical region for growth signal transduction in the cytoplasmic domain of the human IL-4 receptor (hIL-4R). Since the entire cytoplasmic domain of this receptor lacks known catalytic activities such as the tyrosine kinase domain, it is likely that the IL-4R associates with other signal-transducing molecules through this critical cytoplasmic region. We test here whether a synthetic peptide corresponding to this critical cytoplasmic region, designated SP-1, interferes with IL-4-induced proliferation by competing with the IL-4R for binding to intracellular signal-transducing molecules. Our data indicated that 100 micrograms/ml SP-1 peptide completely inhibits human IL-4 (hIL-4)-induced proliferation of Ba/F3 transfectants expressing the full-length hIL-4R (hIL-4R-Ba/F3 transfectants). In contrast, a wide concentration range of an unrelated synthetic peptide, designated SP-2, did not affect hIL-4-induced proliferation of hIL-4R-Ba/F3 transfectants. This difference between SP-1 and SP-2 peptides was not due to their differential uptake by cell, since approximately 100 times more SP-2 peptide could be found in cytoplasmic extracts than SP-1 peptide in experiments using radiolabeled peptides. The specificity of SP-1-mediated inhibition of IL-4-induced proliferation was supported by the fact that the SP-1 peptide had no effect on IL-3-induced proliferation of the same hIL-4-Ba/F3 transfectants. In addition, the SP-1 peptide did not affect either IL-2-induced proliferation of Ba/F3 transfectants expressing the human IL-2 receptor beta chain (hIL-2R beta) or hIL-4-induced proliferation of Ba/F3 transfectants expressing a chimeric receptor consisting of the hIL-4R extracellular domain and the hIL-2R beta cytoplasmic domain. SP-1 was unable to inhibit IL-4-induced proliferation of other IL-4-responsive cell lines such as human erythroleukemic cell line TF-1 and mouse T cell lines HT2 and CTLL-2. In addition, SP-1 caused only a 50% inhibition of Ba/F3 cell proliferation induced by mouse IL-4. The failure of SP-1 to inhibit IL-4-induced proliferation in these various cell lines while producing excellent inhibition of hIL-4-induced proliferation of hIL-4R-Ba/F3 transfectants appeared to be related to the number of IL-4Rs expressed on each cell type.(ABSTRACT TRUNCATED AT 400 WORDS)

Amino Acid Sequence↗
PubMed1995

Subjective complaints in orthopedists and general surgeons.

The aim of this study was to investigate the prevalence of subjective complaints among two groups of health care personnel. Using a mail questionnaire, 63 male orthopedists and 78 male general surgeons were asked to respond to questions on their subjective musculoskeletal complaints as well as their age, occupational career, and daily working time. In the final analysis, 54 orthopedists and 63 general surgeons who were aged < or = 59 years and had worked for at least 5 years in clinical practice were considered. The mean age was 43.3 (SD 7.6) years for the orthopedists and 41.8 (SD 9.5) years for the general surgeons. Their mean employment time was 18.1 (SD 8.9) years and 16.6 (SD 9.5) years, respectively. The average working time per day was 9.5 h. In general, the orthopedists had a higher prevalence of subjective complaints than the general surgeons. Problems in the shoulders and lower back were the most frequently reported complaints, followed by neck problems. There were significant differences (P < 0.05) between the two groups regarding stiffness in the shoulders, stiffness in the lower back, pain in the neck, and numbness in the fingers. When subjective complaints were compared between the junior (employment time: < 20 years) and senior (employment time: > or = 20 years) staff, the junior orthopedists had significantly higher prevalence rates for stiffness in the shoulders, pain in the neck, and stiffness in the lower back.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

[Relationship between chilliness of the limbs and daily-life conditions in young females].

In winter, many people have trouble with chilliness in their arms and legs. Many women are especially sensitive to cold, and for them the chilliness of the hands and the feet is difficult to ease even after entering a warm room, or taking a bath. They even feel pain owing to coldness of their limbs in daily life. This symptom has been called "hiesho" in Japanese. The problem of this chilliness is difficult to study because this symptom, in general, can be cured when spring comes. Coldness of the limbs has been considered to be one of the symptoms of the climacteric disturbance among middle-aged females. Recently, however, it was reported that many young females also feel pain owing to coldness of the hands and legs in their daily life during winter. This study investigates the problems of chilliness in the limbs of young females in their daily life. By means of a questionnaire, 642 female college students aged from 18 to 20 years answered questions concerning: (1) physical characteristics, (2) physical conditions in their daily life, (3) physical conditions in winter, and (4) physical conditions in summer. The replies to the questionnaires were tested using the chi 2 test. The major results were as follows: 1. Half of the subjects were sensitive to cold, and had difficulty sleeping owing to chilliness of their limbs in winter even in a warm environment. For the following results the subjects who were sensitive to cold had significant differences (p < 0.05) compared to non-sensitive subjects to cold.(ABSTRACT TRUNCATED AT 250 WORDS)

Activities of Daily Living↗
PubMed1995

[Relationships between biting force and the morphology of the maxilloface].

The maximum biting force of 40 male students aged 26.1 +/- 3.9 years was assessed to evaluate the relationships between biting force and the morphology of the maxilloface. The evaluations were made using roentgenographic cephalogram measurements and oral model measurements. The results obtained were as follows. 1. The subjects who had strong maximum biting force (MBF) were those with high posterior facial height, high posterior inferior facial height, long length from the Ar-Me line to the gonion, and long length between the adhesion of the masseteric muscles. 2. The subjects who had strong MBF had a small gonial angle, and their occlusal plane and mandibular plane approached the anterior cranial base and eye-ear-plane, that is, the subjects with strong MBF were considered to be persons with a deep overbite. 3. There was a significant positive correlation between MBF and discrepancy values using oral model measurements (p < 0.01). No significant correlations were noted between MBF and the sum of teeth size. 4. There was a significant positive correlation between MBF and maximum grip strength (p < 0.01), back strength (p < 0.01) and the long jump (p < 0.05), and there was a significant negative correlation between MBF and 50m running (p < 0.01), but no significant correlations were noted between MBF and 1500m running.

Adult↗
PubMed1995

[Salivary calcium and total protein in relation to dental caries].

To evaluate the relationship between salivary components (calcium: Ca, total protein: T-Pro) and dental caries, we collected nonstimulated and expectorated saliva from 131 primary school children aged 11 years old. All salivary samples were taken in the morning (11:00-11:30 A.M.) on Feb. 17, 1994, while the subjects were at rest. The salivary Ca concentration (mg/dliter), total salivary protein concentration (mg/mliter) and salivary flow rate (mliter/min) were measured based on the salivary sample taken for each person for 30 minutes at most. For each subject the Ca secretion rate (micrograms/min), T-Pro secretion rate (micrograms/min) and Ca/T-Pro ratio were determined. The numbers of permanent teeth erupted, and decayed, missing and filled (DMF) teeth for each subject were obtained from dental records. For the entire group we observed that the numbers of DMF teeth were highly correlated with the numbers of permanent teeth erupted, hence for further analysis we restricted the subjects to 18 boys and 29 girls who were classified as dental age IIIC-IVA (according to Hellman's classification). Multiple linear regression analysis was employed using the number of DMF teeth as a dependent variable. When we included the variables for the Ca/T-Pro ratio, numbers of erupted permanent teeth, sex and salivary flow rate into the model as independent variables, there was a statistically significant association (P < 0.05) between the Ca/T-Pro ratio and the numbers of DMF teeth. However, in other models there was no significant association between the numbers of DMF teeth with Ca concentration, Ca flow rate, total protein concentration, or total protein flow rate.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium↗
PubMed1995

Immunomodulatory effects of Maharishi Amrit Kalash 4 and 5 in mice.

To evaluate the immunomodulatory effects of two kinds of Ayurvedic food supplements (Maharishi Amrit Kalash 4 and Maharishi Amrit Kalash 5, M-4 and M-5), superoxide anion (O2-) production of peritoneal macrophages and the response of spleen cells to concanavalin A (Con A) were examined in mice given an aqueous emulsion of M-4 and M-5 p.o. at doses of 50 and 100 mg/kg for 10 days. O2- production of peritoneal macrophages in the M-5 (50 mg/kg)-treated group was significantly higher than that in the control group. The indices of stimulation of spleen cells by Con A were significantly (3 to 4 times) higher in groups treated with M-4 and M-5 at all doses than in the control group. These results indicate that M-4 enhances lymphocyte responsiveness and M-5 enhances not only lymphocyte responsiveness but also macrophage function. It is also suggested in this study that M-4 and M-5 have mitogenic effects on lymphocytes.

Adjuvants, Immunologic↗
PubMed1995

Some aspects of occupational safety and health in green tea workers.

The objectives of this study were to evaluate the health and safety conditions of 36 male and 27 female green tea workers who were aged 40-69 years and had worked for at least 5 years in green tea production procedures. The Mean +/- SD of age was 57.1 +/- 5.8 years in males and 54.4 +/- 6.4 years in females. The mean working career was 26.1 +/- 9.5 years and 24.3 +/- 9.1 years, respectively. The most commonly subjective complaints developed while at work was pain in the lower back at a rate of 72.2% in males and 63.0% in females. Regarding persistent subjective complaints, female workers had significantly (P < 0.05) higher prevalence rate for breath shortness (25.9%) compared to that of male workers (5.6%). It was observed that the male workers whose occupational career was equal to or more than 28 years had significantly higher prevalence rates for stiffness in the neck and pain in the arms, compared to those of male workers whose occupational career was less than 28 years. The prevalence of nasal allergy was 11.1% either in the male or female workers. The total rate of accidents during working hours in the male workers was 22.2%, and that in the female subjects was 18.5%. The mean frequency weighted vibration magnitude produced by using tea-leaf plucker was in the range of 2.4-3.5 m/s2. The mean equivalent A-weighted noise level while using the same equipment was 100.6 +/- 5.0 dB(A). The need for occupational safety and health programs in these small farm settings are discussed.

Adult↗
PubMed1995

Operating vibrating tools and prevalence of subjective complaints in vibration syndrome.

The aim of this paper is to evaluate the prevalence of subjective symptoms and signs related to vibration syndrome in various groups of subjects exposed to hand-arm vibration (HAV). In 9 groups of subjects occupationally exposed to HAV, one group of subjects previously exposed to HAV, one control group, and 2 groups of general population (males and females), the prevalence of finger blanching, numbness in the hands, stiffness in the hands, and pain in the hands were investigated. The age of subjects ranged from 25 to 59 years. In subjects exposed to HAV, hand-transmitted vibration levels (HTVLs) were measured by means of vibration dosimeters, and the frequency-weighted acceleration levels [(Lh,w)eq,t] were determined as the vibration levels. The prevalence of vibration-induced white finger (VWF) in the exposed subjects was in the range of 0.0-9.6%, and that in subjects who were previously exposed to HAV was 4.1%. The prevalence rates of finger blanching in males and females of the general population were 2.7 and 3.4%, respectively. The highest prevalence rate of VWF was observed among subjects exposed to HTVLs of 2.7-5.1 m/s2. The prevalence of numbness of the hands fluctuated among the groups; i.e., in the exposed groups: in the range of 6.5-30.4%; in those previously exposed to HAV: 16.4%; and was 13.4% in males and 29.5% in females of the general population. The prevalence rates of stiffness in the hands were in the range of 7.6-65.2% in the exposed workers, 13.7% in those previously exposed to HAV, and was 5.5% in males and 20.9% in females of the general population. The prevalence of pain in the hands was between 7.4 and 17.4% in the exposed groups, 1.4% in those who stopped exposure to vibration, and 1.2% in subjects without segmental vibration exposure. Among the subjective symptoms, only VWF showed a significant positive correlation with the measured vibration acceleration; Y = -0.9 + 1.9 X, r = 0.8, P = 0.01. It was concluded that VWF is the most appropriate signs in decisions concerning quantitative recommendations for segmental vibration exposure.

Adult↗
PubMed1994

Isolation and fluorescence in situ hybridization mapping of 60 cosmid clones on human chromosome 18.

We have mapped 60 new cosmids on the short and long arms of chromosome 18 either by R- or by DAPI-banding and simultaneous fluorescence in situ hybridization. These markers were isolated from hybrid MS126-21 made from a human-rodent hybrid cell line that retained human chromosome 18. Twenty-two of the cosmid probes map on the short arm, and 31 probes cluster in the distal half of the long arm between bands 18q21.1 and 18q23, while 7 other probes are mapped more proximal to the centromere around bands 18q11.1-q12.3. The technique of fluorescence in situ hybridization has proven to be a very efficient methodology for gene mapping. These 60 probes will be useful in the elucidation of genetic alterations associated with diseases such as tetrasomy 18p syndrome, 18q- syndromes, and colorectal cancer.

Animals↗
PubMed1994

Prevalence of Raynaud's phenomenon in different groups of workers operating hand-held vibrating tools.

In eight groups of subjects operating various hand-held vibrating tools and aged from 30 to 59 years, the prevalence rates of vibration-induced white finger (VWF) and numbness, pain, or stiffness in the upper and lower extremities were investigated. Hand-transmitted vibration levels (HTVLs) were measured on the back of the hand, by means of unidirectional (x-axis) vibration dosimeters, and the frequency-weighted acceleration levels [(Lh,w)eq,t] were determined as the vibration levels. The prevalence rates of VWF and numbness of the hands in these subjects were compared to the prevalence rates of Raynaud's phenomenon (RP) and numbness of the hands in 1027 males and 1301 females not occupationally exposed to vibration (age range: 30-59 years). It was observed that in subjects exposed to HTVLs of between 1.1 and 2.5 m/s2, the prevalence of VWF was between 0.0% and 4.8%. The prevalence of VWF reached 9.6% in a group of workers exposed to HTVLs of 2.7-5.1 m/s2. The latter group showed a significant difference (P < 0.05) in the prevalence of VWF compared to the 2.7% prevalence of RP in male subjects of the general population. The prevalence of VWF in female subjects exposed to vibration (4.3%) was not significantly different from the prevalence of RP in females of the general population (3.4%). The prevalence rates of numbness of the hands were in the range of 6.5%-30.4% in the exposed groups and in the range of 13.4%-29.5% in the general population. Among the subjective symptoms, only VWF showed a significant positive correlation with HTVLs (R2 = 0.5, P < 0.05). It was concluded that in decisions concerning quantitative recommendations for vibration exposure, the prevalence of VWF should be employed. With a view to decreasing the risk of developing VWF, estimated vibration safety values for 4 h and 2 h daily exposures are discussed.

Adult↗