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Biomedical subjects

R Ihle

Publications and source records attributed to R Ihle.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Comparative study of the efficacy of the DBVCy protocol (daunoblastin, bleomycin, vincristine, cytostasan) and the ABVD protocol in advanced Hodgkin's lymphoma. A prospective inter-clinic study within the framework of the Hauptforschungsrichtung Geschwulsterkrankungen].

In MOPP-resistant patients with Hodgkin-lymphoma stage III B and IV the well known ABVD-protocol was compared with the DBVCy-protocol (daunorubicin, bleomycin, vincristine, cytostasan) in a randomized prospective trial. 73 patients were evaluable, 35 received ABVD, 38 DBVCy. 4 out of 35 (11%) in the ABVD-group and 9 out of 38(24%) in the DBVCy-group reached complete remission. The median duration of the remission for DBVCy was 4,5 months, for ABVD 3,4 months (no significance). Median survivals (61 months in DBVCy and 37 months in ABVD) did not show significant differences; but the DBVCy-scheme seems to be better tolerabel. With the given evaluation can not be proved a difference between the two groups, but it is not likely, that one of the regimen is very much better or very much worse as the other.

Adult↗
PubMed1983

[Risk of leukemia in aplastic anemias].

Nowadays an increased risk of leucaemia in patients with aplastic anaemias (insufficiency of the bone marrow) is regarded as certain. If the literature of the last 10 years is analysed, the data concerning a leucaemic transformation amount to values between 0 and 16%. Among our clinical material of 108 patients, 38 of them living, 10 patients (correspondingly 9%) showed a leukaemic transformation. The temporary latency between diagnosing of the aplastic syndrome and the leucaemic transformation was maximally 20 years. By cytomorphological investigations, particularly of the judgment of anomalies of erythroblasts, no certain prognosis concerning a possible development of leucaemia. Also cultivation methods of myelopoietic stem cells by means of diffusion chamber and agar culture technique do not seem to allow a certain evidence on prognosis.

Anemia, Aplastic↗
PubMed1982

[Anthracyclin-cardiomyopathy (author's transl)].

Doxorubicin is one of the most effective antineoplastic drugs in clinical practice. Its clinical usefulness extends from acute leucemia and lymphoma to a wide range of solid tumors. However, the use of this drug is limited by its cardiac toxicity, that is often life-threatening. A number of clinical approaches discussed in this paper have been used to circumvent the problem of doxorubicin-induced congestive heart failure. A summarizing survey of the literature has led to establish two principles for prevention of doxorubicin-induced congestive heart failure with clinical meaning in the moment: --the way of administration --the clinical use of Ca-antagonist. The two principles provide an objective basis for preventation of congestive heart failure. The pathobiochemical background, analysed in this paper in detail, demonstrates that the same metabolic condition exist in the myocardial cell as in red blood cell. These interactions are the basis for a further analysis of metabolism in the cell, especially the redox metabolism of glutathione.

Animals↗
PubMed1978

[Methods and techniques of sampling and performing of cytologic lymph node smears (author's transl)].

Within the diagnostics of lymphoma the indication for cytodiagnosis and the coice of gaining material and its preparation (punction and exstirpation of lymph nodes with making smears in a squeezing manner to effect simulated tissue pattern) are the basis of an appropriate and effective work of the cytologist. The good diagnostic efficiency of the cytodiagnosis of lymph nodes is in no proportion to the totally insufficient application of those methods by physicians of various medical disciplines in the hospitals and outpatient departments. The lack of an adequate teaching of students and postgraduates is a main reason for the described situation. In order that each physician may have the possibility to apply the cytodiagnosis of lymph nodes within his diagnostic programms, some special references are given for the gaining and preparation of lymph node material.

Cytodiagnosis↗
PubMed1978

[Non-secreting plasmacytomas].

In non-secernent plasmocytomas there are no characteristic changes of serum protein. Diagnostic difficulties may be overcome by cytomorphological examinations, immunofluorescence and electron microscopy. By referring to 4 own observations the value of the electron microscopic characteristics of plasma cells is demonstrated. Subtile investigations in protein diagnostics are required for avoiding incomplete monoclonal immunoglobulins which may greatly enter the kidneys to be overlooked. Generally the prognosis of non-secernent plasmocytomas is not worse than that of other forms.

Aged↗
PubMed1977

[Bone-marrow insufficiency].

In a survey the definition of the notions insufficiency of the bone marrow, panmyelopathy, panmyelophthisis and aplastic anaemia, the subdivision into congenital and acquired forms as well as to the clinical course, the epidemiologic situation as well as the distribution according to age and sex are described. More in detail the author enters the etiological factors, in which cases the etiological classification of the individual case may be connected with considerable difficulties. Exogenic noxae are subdivided into factors dependent on dose and independent on dose as pathogenetic principles. In this connection professional noxious substances as well as unwished side-effects of medicaments are discussed more in detail. Despite all variety the possibilities of therapy are limited.

Adolescent↗
PubMed1975

[Hematologic function tests in early diagnosis].

The functional tests in form of tolerance tests allow an insight into the adaptibility of the organism to changed inner and outer conditions. The majority of haematological functional tests demands a temporary and economic expediture which excludes it a priori as screening test. According to a previously published phase program for the haematological functional diagnosis a report is given on simple methods for judging the disturbed partial functions of the blood.

Adaptation, Biological↗