Action of detergents on membranes: differences between lipid extracted from red cell ghosts and from red cell lipid vesicles by Triton X-100.
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Biomedical subjects
Publications and source records attributed to R I MacDonald.
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Reconstitution of glycophorin into dimyristoyl phosphatidylcholine and sphingomyelin vesicles was sub-maximal below the phase transition temperatures of these lipids. Reconstitution of glycophorin into diisostearoyl phosphatidylcholine and dioleoyl phosphatidylcholine liposomes was maximal within a range of temperatures below the phase transition temperatures of dimyristoyl phosphatidylcholine and sphingomyelin but above the phase transition temperatures of diisostearoyl phosphatidylcholine and dioleoyl phosphatidylcholine. These findings indicate a greater tendency for reconstitution of glycophorin into fluid as opposed to solid lipid phases.
A protocol for osteoarticular grafting was established to avoid fracture, nonunion, and loss of motion when replacing the distal radius. Proximal fibular autografts were used and stabilized proximally by compression plating and, at the wrist, by ligamentous reconstruction. Postoperative splinting and therapy were coordinated with graft healing, which was monitored by bone scans and roentgenograms. Graft incorporation in three patients appeared to be well-established within 1 year, but functional use of the extremity and return to duty were achieved much earlier.
Review of a series of 186 operative cases of carpal tunnel release revealed 34 complications in 22 patients, for an incidence of 12%. Complications were grouped into seven categories: (1) inadequate section of the transverse carpal ligament (associated with both transverse and curved incisions), (2) symptoms related to damage to the palmar cutaneous branch of the median nerve, (3) reflex sympathetic dystrophy, (4) unsightly hypertrophic scar due to inappropriate incision, (5) damage to the superficial palmar arch following blind sectioning of the transverse carpal ligament, (6) bowstringing of the flexor tendons after excision of the transverse carpal ligament, and (7) adherence of the flexor tendons following excision of the mesotenon. Except for four of the complications, two each of bowstringing and reflex sympathetic dystrophy which occurred in our own practice, all of the complications were seen in patients referred for care. Most complications can be prevented by proper operative technique.
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A review of thirty-eight patients with Kienböck's disease indicated that both delay in diagnosis and prolonged treatment by plaster immobilization led to progressive collapse of the lunate and an unsatisfactory result in most instances. Four clinical and roentgenographic stages were identified, and the results of silicone replacement arthroplasty were correlated with the preoperative stage after an average follow-up of twenty-seven months. The results were satisfactory in fourteen of twenty wrists in which the procedure was performed before collapse of the lunate had occurred. The importance of early diagnosis and early surgical treatment of this disorder was emphasized by the findings in this study.
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This article describes the assessment process by which learning needs of a select group of nurses in a forensic psychiatric setting were identified and used for continuing education (CE) program planning. To determine whether a gap existed between what the nurses currently knew and what they needed to know in order to have a sense of accomplishment, their personal accounts of satisfying and unsatisfying nursing experiences were analyzed. The factors that influenced these experiences were categorized according to a theory of basic human needs, and learning needs were identified from those categories. Implications for the planning of content and methodology of CE programs for the study group were then developed.
Sea urchin spine injury is usually a benign process that rarely comes to the attention of a physician. Aside from the transient episode of excruciating pain which responds dramatically to hot water soaks, there is usually no residual disability. As in any puncture wound, tetanus prophylaxis and observation for latent infection is advised. Complications arise, however, when spines are embedded over bony prominences, within joints, or in contact with nerves. Cases are reported herein of the latter two problems occurring in the hand. A case of a neuropathy associated with sea urchin injuries has not been previously reported in the literature. When such injuries necessitate exploration, aseptic surgical technique is required.