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Biomedical subjects

R I Krylova

Publications and source records attributed to R I Krylova.

At least 19 recordsLinked to original sources
PubMed2004

[A comparative description of amyloidosis in monkeys].

The paper contains the results of a postmortem study of 461 cases of amyloidosis in monkeys of 4 species (Papio hamadryas, Macaca mulatto, Macaca fascicularis and Macaca nemestrina) from the Sukhumi and Adler primatological facilities. Emergence of amyloidosis was found to be dependent on age; the frequency ratio at which separate organs are affected is presented; the specific disease signs are described for different monkey species. Generalized and isolated cases of amyloidosis are elucidated with the liver being the most vulnerable organ in macaques (64%) and the kidneys--in baboons (94%). A comparative description of different forms of amyloidosis in monkey and man was made use of to suggest using the amyloidosis in monkeys as a model process for studying the pathology in man.

Aging↗
PubMed2004

[Infectious pathology of monkeys: a brief description, potential experimental research, safety for attendants at primate care facilities and laboratories].

Infectious diseases of monkeys, including the bacterial anthroponosous and zoogenous as well as viral infections, are described in the paper. A bulwark of research resulted from authors' independent long-term observations of monkey pathologies at Sukhumi and Adler primatological facilities. Pathologies are elucidated, which are better to be modeled in monkeys; there are also diseases that can be studied only in monkeys. Monkey agents were isolated, which are dangerous to humans attending the animals at primatological facilities and laboratories.

Animals↗
PubMed2003

Amyloidosis in macaques in adler primatological center.

Results of pathomorphological studies of 133 amyloidosis cases in macaques of 3 species (M. mulatta, M. nemestrina, and M. fascicularis) in the Adler Primatological Center are presented. A relationship between the development of amyloidosis and animal age is detected and the incidence of involvement of various organs is determined. Generalized and isolated forms of amyloidosis are described, the most incident of which (36.8%) was hepatic amyloidosis. Simian and human amyloidosis are compared. Amyloidosis in macaques can be used as the model process for studies of amyloidosis in humans.

Amyloidosis↗
PubMed2002

Experimental Mycoplasma infection in monkeys.

Experimental mycoplasma infection was studied in Papio hamadryas, Macaca mulatta, and Macaca nemestrina infected with Mycoplasma (M. pneumoniae and M. hominis) and Ureaplasma (U. urealyticum).

Animals↗
PubMed2001

Spontaneous simian mycoplasma infection.

We present our many-year studies of spontaneous Mycoplasma infection in monkeys. Mycoplasma flora of healthy, acclimatized, and sick monkeys of different species is characterized. S ome characteristics (including pathogenic properties) of new Acholeplasma isolated from monkeys are described.

Adipose Tissue↗
PubMed1991

[The chronic course of spontaneous and experimental hepatitis A in rhesus monkeys with viral persistence].

The prolonged (up to 2 years) complex observation of 11 rhesus macaques (Macaca mulatta) with spontaneous hepatitis A and 14 rhesus macaques with experimental hepatitis A developing after their intravenous and/or oral infection with human hepatitis A virus (HAV). Both natural and experimental infection took a chronic course (15-18 months). In 13 monkeys showing morphological changes in the liver during the whole period of the disease elevated enzyme levels in the blood and virus shedding in feces were periodically observed. Only one monkey had acute hepatitis A which lasted 1.5 months. In 11 monkeys the disease took an undulating course with 1-2 relapses when virological, biochemical and morphological signs of the disease could be detected. Seroconversion was observed in all monkeys. Anti-HAV IgM antibodies were retained for not more than 6-7 months and total anti-HAV antibodies, during the whole period of observation. Relapses were found to induce no antibody formation. Evidence on the prolonged (up to 12-16 months) persistence of HAV in primates was obtained for the first time.

Animals↗
PubMed1991

[Comparative morphology of spontaneous hepatitis A in lower Old World monkeys].

Detailed description of liver damage in two species of macaques (rhesus and fascicularis) and green monkeys with spontaneous hepatitis A (HA) induced by the virus similar to human hepatitis. A virus (HAV) is given. Evolution of histological changes was followed by serial liver biopsies. The picture of the hepatitis in the above monkey species resemble that of human NA as well as HA in other monkey species susceptible to HAV. Only in 8 of 21 monkeys the disease lasted for 2-5 months, others exhibited undulating and lingering course which lasted 8-19 months from the beginning of the infection. The lingering course of the infection was caused by HAV persistence in the host with its periodical elimination in faeces.

Animals↗
PubMed1990

Urethral infection of male monkeys by Mycoplasma hominis and Ureaplasma urealyticum.

Seven male Macaca nemestrina, eight male Macaca mulatta and three male Papio hamadrias were infected with M. hominis or U. urealyticum separately or simultaneously into the urethra. Animals of the first two species exhibited moderate infection and mild clinical urethritis characterized by increased number of PMNL in the urethral discharge and colonization and lymphocytic infiltration of the mucous membrane of the urethra and urinary bladder. Animals of the third species proved to be less sensitive.

Animals↗
PubMed1990

[Experimental model of hepatitis A in rhesus monkeys (Macaca mulatta) infected with human hepatitis A virus].

The focus of this paper is characterization of Hepatitis A experimental model obtained for the first time in rhesus monkeys (M. mulatta) infected with fecal isolate from a patient with Hepatitis A (HAV-H1). Monkeys were susceptible to oral and intravenous routes of HAV inoculation. The disease could be reproduced regularly in 4 passages as a result of which HAV strain continuously pathogenic for M. mulatta has been established. All 17 infected monkeys developed Hepatitis A with characteristic (except jaundice) patterns: shedding of virus with the stool, elevations of serum alanine aminotransferase level, appearance of IgM anti-HAV, morphological changes developed in the liver. Our data have demonstrated that the course of experimental Hepatitis A infection in M. mulatta is similar (in many respects) to that observed in man.

Administration, Oral↗
PubMed1990

[The infection of monkeys with Ureaplasma urealyticum serovar VIII].

The possibility of modeling chronic infection on monkeys by the injection of the culture of U. urealyticum, serotype VIII, was shown. The infection of monkeys with these microorganisms introduced in a single intraperitoneal injection resulted in the generalization of the process, which was manifested by the persistence and reproduction of the infective agent in the organs and blood of the animals for as long as 6 months (the term of observation). Lymphoid hyperplasia in the organs of immunogenesis and transitory immunomorphological reaction in the tissues of some organs of the urogenital system were noted. The localization of infective agents in some endocrine glands was not accompanied by disturbances in their function.

Animals↗
PubMed1989

Isolation of M. pneumoniae from monkeys (Presbitus cristata).

Monkeys of the species Presbitus cristata died of severe interstitial pneumonia 20-60 days after their transportation. The carcases were examined for the presence of mycoplasmas. Thirty-six out of 65 samples obtained from the liver, spleen, kidney, lung, lymph nodes, pharynx, bronchi and blood of 13 monkeys contained mycoplasmas biochemically and serologically identical with M. pneumoniae. The isolated strains were able to elicit a rise in body temperature and an elevation in the number of leucocytes in blood as well as development of interstitial pneumonia, colonization of the inner organs by the mycoplasmas and a serological response in the experimentally infected guinea-pigs.

Animals↗
PubMed1988

[Viral hepatitis A in lower Old World monkeys (possibility of use as a model for vaccine testing)].

Morphological, virological and serological data characteristic of spontaneous hepatitis A in macaques and green monkeys have been presented. The disease similar to human hepatitis A was induced in M. iris macaques, with the virus isolated from spontaneously infected rhesus monkeys. Experimental model of hepatitis A in macaques is likely to be used for the testing of vaccines and antiviral preparations.

Animals↗
PubMed1987

[Experimental Mycoplasma infection of the urogenital tract in monkeys].

The possibility of the experimental reproduction of infectious urethritis in monkeys by infecting them with mycoplasma and ureaplasma cultures, newly isolated from human patients, has been shown. In monkeys inoculated with the mixture of mycoplasmas and ureaplasmas, more pronounced infectious urethritis with the symptoms of ascending infection develops. The animals who have had the disease do not develop resistance to repeated infection.

Animals↗