Biomedical subjects

R I Brown

Publications and source records attributed to R I Brown.

At least 37 records · Page 2Linked to original sources

PubMed1991

Balloon expandable stents for acute closure post failed coronary angioplasty: case report and review of the literature.

Abrupt closure of a dominant right coronary artery occurred in a patient 1 h post coronary angioplasty. Angiography revealed a long spiral dissection involving the mid to distal segment of the right coronary artery. Four intracoronary balloon expandable stents were deployed to 'tack up' the dissection and recanalize the occluded artery. Six month follow-up angiography revealed continued patency of the stented segment. Balloon expandable stents may be an effective alternative to coronary bypass surgery in the treatment of acute closure following coronary angioplasty.

Acute Disease↗

PubMed1989

The physics of continuous flow centrifugal cell separation.

The governing equations defining the separation of blood in continuous flow centrifuges are derived using an empirical model for the viscosity of blood. The effects of fluid shear on the separation process are addressed and further models are developed to permit estimations of shear rate during centrifugation. Simplified predictive equations for species specific separations are developed. Contributions due to shear enhanced diffusion are addressed and found to be negligible at the discontinuous interface between cells and plasma. Experimental results from an investigational centrifuge are presented and compared with theoretical predictions. The role of rouleaux formation in conventional centrifuges is discussed and known centrifugal separation characteristics are explained. The viscosity of blood is related to that for suspensions of rigid particles and an equation for the hydraulic permeability of red blood cell suspensions is derived.

Blood Component Removal↗

PubMed1988

An outcome study of Gamblers Anonymous.

Retrospective and prospective studies of a total sample of 232 attenders at groups of Gamblers Anonymous suggest that total abstinence from gambling was maintained by 8% of all comers at one year from first attendance and by 7% at two years.

Alcoholics Anonymous↗

PubMed1987

Gambling addictions, arousal, and an affective/decision-making explanation of behavioral reversions or relapses.

Cognitive-behavioral models of behavioral reversions or relapses in the addictions are inevitably incomplete because they miss affective and decision-making factors in the relapse process. They over-emphasize the importance of external "relapse-provoking" situations and under-value or ignore important intrapersonal determining processes. A theoretical model of an affective/decision-making factor in reversions or relapses, derived from studies in the role of arousal in gambling addictions, is developed and applied to addictions in general. Some of the implications of this model for the further classification and study of behavioral reversions are explored, and the options for testing it empirically are outlined.

Affect↗

PubMed1986

Organization problems and strategies; a dilemma for the rehabilitation agency director.

During the last 20 years there has been considerable progress in the development of rehabilitation knowledge and philosophy, particularly in the behavioural and social aspects of programming. Frequently these changes are not applied, either because of lack of information amongst senior staff and board members, or because of pressures within the community. The article describes issues and concerns related to agency function, including changes that need to occur in philosophy and operation to provide a more individualized service.

Canada↗

PubMed1985

The use of dextran-40 during percutaneous transluminal coronary angioplasty: a report of three cases of anaphylactoid reactions--one near fatal.

Successful percutaneous transluminal coronary angioplasty is achieved by fracture of the atheromatous plaque and perhaps dilatation of the arterial walls to increase the luminal diameter of the artery. Because this "controlled" injury stimulates platelet adhesion on the subendothelial matrix, the use of dextran-40 in addition to heparin has been advocated. The overall incidence of Dextran-induced anaphylactoid reactions at our institution was 0.6% and of severe life-threatening reactions, 0.2%. With the recent doubts cast on the efficacy of dextran-40, the question arises regarding its routine use in PTCA.

Aged↗

PubMed1984

Real and laboratory gambling, sensation-seeking and arousal.

The existence and importance of excitement in gambling, the effects of runs of wins and losses on gambling behaviour and the relationships of both with sensation-seeking were investigated using samples of students and experienced gamblers in real and artificial gambling situations. Heart-rate increases, gambling behaviour and events such as 'stake decision time' were recorded as subjects played blackjack. Significant differences between real and artificial casinos were found for mean heart-rate increases over base-lines, for gambling behaviour and in the relationships between sensation-seeking, arousal and gambling in the two conditions. Doubt is cast on laboratory gambling as a valid analogue of the real gambling situation. Sensation-seeking and arousal are discussed briefly in relation to explanations of gambling.

Arousal↗

PubMed1984

Mental development of adults with Down syndrome.

Measures of cognitive, verbal, and functional performance obtained at widely separated time periods were examined for adults with Down syndrome. Comparisons of first and last test profiles for Raven Coloured Progressive Matrices, Peabody Picture Vocabulary Test, and Adaptive Functioning Index (Social Education) Test all demonstrated significant increases over a mean time span of 5 years. These increases could not be attributed to year of entry into program, history of institutionalization, or age of the individuals. The findings indicate that mental development of adults with Down syndrome continues well into the third and fourth decade of life.

Adolescent↗

PubMed1974