Two sisters (6 and 8 years old) fell ill with coughing, fever and dyspnea after playing in the rotten straw in the barn of their parents' farm. Within 2 weeks symptoms changed to the insidious form of Exogen Allergic Alveolitis. In the broad spectrum of antibodies detected, the Thermophile Actinomycetes were probably the relevant antigens. In spite of efforts to avoid contact with the antigens, there was a relapse of the disease, the most probable sources of the antigens being a mattress in the bed-room and a fodderroom. Since consequent avoidance of antigens is practiced, no signs of relapse have been seen. The other three members of the family were exposed too. The mother and the youngest daughter showed neither symptoms nor specific antibodies. The father turned out to be sensibilitized too. By more attentive self-observation he discovered signs of illness. The distribution of the HLA-markers in the family was not concordant with the pattern of disease nor of antibodies. Some HLA-markers have been described as being associated with Exogen Allergic Alveolitis. Among the markers of our family there are none of these.

Child↗

PubMedDate not supplied

[The significance of health risks caused by outdoor pollution, demonstrated by cross-sectional studies of pseudocroup in Baden-Württemberg].

In the FRG the question of health effects by ambient (outdoor) air pollution is often considered with respect to respiratory diseases in children, especially group syndrome. Therefore, the results of a cross-sectional study in Baden-Württemberg are discussed as an example for the role of "outdoor pollution" at presently observed concentrations. In the study that was performed in Stuttgart, Tübingen/Reutlingen and Freudenstadt, the parents of 8.420 children at the age of 6 years participated (response rate 93%). Their reports on diseases were additionally validated and completed by the paediatricians concerned. The "crude" prevalence for the age group 0-6 years is about 9% each for croup syndrome and obstructive bronchitis. This is strongly influenced by sex, disposition in the family, education and nationality of the parents. In contrast, influences of ambient air pollution are less clear or missing. Pollution measurements on a sufficient spatial scale were only available for Stuttgart, where logistic regression showed after adjustment for the relevant confounders only that croup syndrome was slightly increased in streets with high traffic load. For childhood asthma (prevalence 1.5%) a correlation with traffic-dependent pollutants (NO2, NO, CO) and traffic load is found. These results are compared with those from North Rhine Westphalia, and their limitations are discussed.

Air Pollutants↗