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Biomedical subjects

R Huch

Publications and source records attributed to R Huch.

At least 199 records · Page 11Linked to original sources
PubMed1981

In vivo oxygen dissociation curve for whole fetal blood: fitting the Adair equation and blood gas nomogram.

Oxygen tension, oxygen saturation of haemoglobin, plasma pH and carbon dioxide tension were analysed from 436 blood samples of the umbilical arteries and umbilical vein and 33 blood samples obtained by puncture of the arteria radialis of newborn younger than one day. A computer was used to fit the data to the Adair equation, and to calculate the pH-and Pco2-shift of the oxygen dissociation curve. The results were translated into a Po2-So2-pH-Pco2-nomogram.

Blood Gas Analysis↗
PubMed1981

Comparison of continuous transcutaneous Po2 measurement with intermittent arterial Po2 determinations in fetal lambs.

This study determined the validity of transcutaneous Po2 (tcPo2) versus Pao2 determinations in the sheep fetus. In 7 fetal lambs catheters were placed in the carotid artery and the trachea, and ECG leads and a tcPo2 electrode were attached. Intermittently determined Pao2 values were compared to continuously recorded tcPo2 values. Fetal tcPo2 values ranging from 12 to 29 mmHg were achieved by changing the gas mixture the ewe breathed or by inflation of a balloon catheter in the maternal aorta. Transcutaneous Po2 correlated strongly with Pao2 (r = .91). These studies indicate that the tcPo2 electrode precisely and accurately reflects Pao2 in the fetal lamb. Limitations of tcPo2 measurements regarding prolonged attachment of the electrode to the fetal skin as well as fetal skin tolerance to the heat of the electrode have been identified. With this electrode the changes in oxygen tension can be compared with changes in fetal cardiovascular variables, eg, heart rate, blood pressure, and ECG, for a better understanding of the effects of hypoxemia on the fetus.

Animals↗
PubMed1979

Integrated interpretation of fetal heart rate, intrauterine pressure and fetal transcutaneous PO2.

By a study of the patterns of changes and the temporal relationship in fetal heart rate, intrauterine pressure, fetal tcPO2 and 'flow', a series of ten typical examples of combined patterns are described. Fetal tcPO2 is affected by the level of the fetal oxygenation and by the blood flow beneath the electrode. Should the latter be below a certain critical level fetal tcPO2 will be lower than fetal scalp blood PO2. By the integrated analysis of the four simultaneously recorded variables the different factors dominating fetal tcPO2 may be identified.

Female↗
PubMed1979

Correlation between fetal scalp tcPO2 and microblood samples.

In summary we would like to state that the correlation between tcPO2 recorded from human fetal scalp and microblood PO2 is quite good. High tcPO2 values are very reassuring for the clinician and indicate a good oxygenation of the fetus. In the presence of a low tcPO2 reading, other signs of fetal hypoxia like abnormal heart rate patterns or a low microblood PO2 are required to confirm the diagnosis. If a low tcPO2 is the only sign suggestive of fetal hypoxia and all other parameters are normal, we recommend removal of the electrode and reapplication in a different spot.

Blood Gas Analysis↗