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Biomedical subjects

R Hoppe

Publications and source records attributed to R Hoppe.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Testing for neutral-to-ground connections in new construction.

A study was performed to seek out inadvertent connections between neutral and ground in the power distribution system of a newly constructed hospital, prior to occupancy. Such connections are not only violations of code but could cause medical device problems. Ground wires are not intended to carry load currents except during faults. When currents do flow in grounds, medical device chassis voltages are elevated and some devices may respond unpredictably. Suitable acceptance testing is not commonly done. In this study, a simple test method was developed that helped reveal and correct many neutral-ground misconnections. The authors advocate incorporating such a test into building construction contract specifications.

Electric Power Supplies↗
PubMedDate not supplied

[The problem of Bechterew's disease from the viewpoint of social security].

Ankylosing spondylitis has a medically well defined clinical picture. It was investigated how often the social security has to deal with it with regards to pension and treatment. The investigations were based on the statistics of the "Verband Deutcher Rentenversicherungen" and 2 groups of the "Landerversicherungsanstalt Rheinprovinz", and the number of individuals who in 1969/70 received a pension because of this disease (n = 157) or received a treatment payed by the social security. The pensioners were observed over a period of 7 years. 21.7% had died and 27.4% were receiving a pension because of disability. Most of the insured persons who had died had not had treatment. From the insured persons who had had treatment 7 years earlier (n = 971) 3% had died and only 16% had applied for a pension, almost always with success. It is pointed out that in case of medical diagnosis the discrepancy between objective finding and the patients' willingness to work must be considered together. There are considerable doubts with regards to drawing any epidemiological conclusions from these results.

Adult↗
PubMedDate not supplied

Non-Hodgkin's lymphoma of the paranasal sinuses: clinical and pathological features, and response to combined-modality therapy.

PURPOSE: Lymphomas of the paranasal sinuses may have poorer prognoses compared with other extranodal lymphomas of the head and neck, and are not well defined as a particular clinicopathologic entity. The outcome of combined-modality therapy and central nervous system (CNS) prophylaxis has not been fully determined. PATIENTS AND METHODS: We retrospectively reviewed our experience with 16 consecutive, carefully defined patients, all treated with both chemotherapy and radiotherapy. RESULTS: There were 11 men and five women, mean age 52. All presented with local symptoms; 13 had stage I or II disease. Thirteen had diffuse large cell lymphoma, two diffuse mixed, and one small noncleaved. Phenotyping revealed 10 B-cell, four T-cell, and two T or natural killer (NK). Most received CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy; the order of chemotherapy and radiotherapy varied. Twelve received CNS prophylaxis. Of 12 complete responses, six relapsed, all at distant sites, and two died during initial therapy. Five-year survival was 29%, and median survival 18 months. Four of 10 B-lineage patients were relapse-free at 4 years; all six T- or T/NK-lineage patients relapsed or were dead within 6 months. Tumors of T or NK lineage often expressed CD56 and showed evidence of Epstein-Barr viral infection; otherwise, pathological features were not predictive of lineage or outcome. Neither age nor lactate dehydrogenase predicted prognosis. No complete responder recurred in the CNS as site of first relapse. CONCLUSION: Despite localized stage at presentation, sinus lymphoma is an aggressive disease, characterized by distant relapse and early mortality. Combined-modality therapy with CNS prophylaxis improves outcome compared with radiotherapy alone; however, prognosis remains poor. Patients with T-lineage disease appear to have a particularly bad outcome. Autologous bone marrow transplantation should be evaluated as first-line therapy for those at high risk of relapse.

Adolescent↗