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Biomedical subjects

R Hong

Publications and source records attributed to R Hong.

At least 199 records · Page 11Linked to original sources
PubMed1973

Beta 2-microglobulin: association with lymphocyte receptors.

beta(2)-Microglobulin (beta(2)m) is a low-molecular-weight protein constituent of lymphocyte membranes. Amino acid sequence analysis has revealed a high degree of homology between the beta(2)m and certain regions of immunoglobulin molecules, suggesting a possible recognition function for the beta(2)m, in analogy with the immunoglobulins. The data presented demonstrate that highly specific antiserum against beta(2)m blocks lymphocyte reactivity against allogeneic cells in mixed leukcocyte cultures and against phytohemagglutinin, both of which processes presumably function via a cell surface receptor on thymus-derived (T) lymphocytes. There is very little inhibition of T lymphocyte rosette formation with sheep red blood cells. The findings suggest a possible relation between the beta(2)m and recognition units on the T lymphocyte surface.

Animals↗
PubMed1973

Antibody-associated lymphotoxin in acute infection.

Five pediatric patients who were known to be previously healthy acutely developed lymphopenia during various viral or mycoplasma infections. In one case, fatal generalized varicella occurred and in another, severe toxic epidermal necrolysis ensued. To further investigate this phenomenon, a study was done to determine the incidence of and elucidate the pathogenesis of lymphopenia occurring during the acute phase of viral or mycoplasma infections. Acute and convalescent sera from patients with viral or mycoplasma infection and children immunized with live measles virus were screened for lymphocytotoxic activity against normal lymphocytes by the microcytotoxicity method of Terasaki and McClelland (1). Sera with lymphocytotoxic activity were found in 15 of 48 cases of viral infections, 4 of 22 mycoplasma infections, and 1 of 11 measles virus immunized persons. All those who had sera which were cytotoxic to lymphocytes in vitro had lymphopenia. The lymphocytotoxic activity resided in 19S fractions in 8 of 11 positive sera while the remaining 3 had activity both in 19S and 7S fractions and could be completely removed by absorption with antilight chain antiserum. The cytotoxic activities were all complement-dependent and were greater at 37 degrees C than at 4 degrees C. The significance of acute acquired immunologic deficiency due to the development of antibody-associated lymphotoxin (AbAL) during acute infections is discussed and five cases having more severe clinical manifestations are presented (Appendix).

Acute Disease↗
PubMed1972

Serum proteins of gnotobiotic rats.

Cellulose-acetate and agar gel immunoelectrophoresis were used to study the serum protein patterns of germfree rats before and after monoassociation with a pure culture of Staphylococcus aureus (phage type 80/81), Streptococcus faecalis, Lactobacillus acidophilus, Bacteroides fragilis, Pseudomonas aeruginosa, or Proteus vulgaris. All six bacteria quickly established themselves in the gastrointestinal tract of the germfree rat, and all six increased the animals' total serum proteins. Only S. aureus and P. aeruginosa caused a noticeable rise in gamma globulins. L. acidophilus, S. faecalis, and B. fragilis multiplied readily in the gastrointestinal tract but caused only minimal alterations in the serum proteins. P. vulgaris caused a marked increase in the alpha and beta, but not the gamma globulins.

Agglutinins↗