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Biomedical subjects

R Hofmann

Publications and source records attributed to R Hofmann.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

The in vivo antibody response to hen egg white lysozyme in H-2b-compatible responder and non-responder mice: is it regulated by its N-terminal peptide at the level of antigen-presenting cells?

We studied the in vivo antibody responses of three H-2b strains, BALB/b, C57BL/6 and BALB/B x C57BL/6 F1 to various lysozymes, REL and HEL, after priming with HEL, REL or the HEL N-terminal peptide. It was confirmed that C57BL/6 is a non-responder strain to HEL and that BALB/b is responder strain. The C57BL/6 non-responder trait was associated with HEL or peptide induction of suppressor cells, as shown by adoptive transfer experiments. We further demonstrated that the suppressor/non-responder trait is dominant in BALB/b x C57BL/6 F1 hybrids and that appropriately pulsed macrophages of BALB/b mice can bypass such suppression in these F1 mice. Possible mechanisms are discussed.

Amino Acid Sequence↗
PubMedDate not supplied

[The familial undescended testis].

BACKGROUND: Testicular maldescent affects 1 % of all 1 year old boys. The observation of familial undescended testis (UDT) was confined to the description of individual cases respectively particular families. The aim of our study was to evaluate the frequency of a positive family history and the frequency of associated urological anomalies in family members and to calculate the risk for new born male individuals to have UDT if a family member is affected. PATIENTS AND METHODS: 74 patients who underwent surgery because of UDT and 374 matched controls without UDT (control group) were interviewed by means of a special questionnaire. We asked for a family history of UDT, as well as for other urogenital anomalies respectively organ alterations (varicocele, hydrocele, hypospadia, testicular cancer, renal anomalies) and reviewed the medical records. For statistical analysis the odds ratio were calculated. RESULTS: 85/374 (22.73 %) of the analysed patients had family members with UDT versus 28/374 (7.5 %) of the control group. Brothers were involved in 37.3 %, fathers in 35.2 %, uncles in 23.5 %, cousins in 16.5 %, great-cousins in 8.2 % and grandfathers in 7.1 %. The familial cluster (risk for UDT in new born male) is 3.6-fold over all (2.306; 5.727), 6.9-fold if a brother and 4.6-fold if the father is affected. The rate of family members with UDT and/or other urogenital anomalies in the patients group was nearly 2-fold higher as in the control group (14 % versus 7.8 %). CONCLUSIONS: In our series the presence of UDT is much more frequently present than described in the literature so far. Due to the high familial cluster and the higher percentage of a positive family history for UDT and/or other urogenital anomalies in patients with UDT, a genetic predisposition is probable. Male descendants show a 3.6-fold increased risk in relation to the normal population, if a family member is already affected.

Adolescent↗
PubMedDate not supplied

Aurintricarboxylic acid and polynucleotides as novel inhibitors of ribonucleotide reductases.

Ribonucleoside diphosphate reductases isolated from Escherichia coli, baker's yeast, Ehrlich ascites tumor cells, and unicellular green alga (Scenedesmus obliquus) are inhibited strongly and uniformly by the polymeric triphenylmethane dye, aurintricarboxylic acid. The molecule appears to interact simultaneously with the enzyme's various nucleotide and catalytic (iron-organic radical) sites. Oligo- and polyribonucleotides are also inhibitory. These reactions serve as models of the probably physiologic regulation of ribonucleotide reduction exerted by natural inhibitors. Partial characterization of an inhibitor fraction found in wheat seed embryo is described.

Animals↗
PubMedDate not supplied

[Need and consent for stomatologic treatment in elderly citizens. A comparative analysis of elderly persons in their own home and residents of retirement and nursing homes in the Hildburghausen district].

An analysis of the situation of dental care, in consideration of aspects of social hygiene, took place in the Hildburghausen district in 1986, using the method of interview and oral examination of 249 old aged peoples - living in homes for the aged and 155 pensioners - living in their own residences.

Aged↗