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Biomedical subjects

R Hoffman

Publications and source records attributed to R Hoffman.

At least 433 records · Page 24Linked to original sources
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Men as well.

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Geriatric Nursing↗
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Isoniazid poisonings in New York City.

We identified 41 New York City residents who had been hospitalized at least overnight between January 1992 and September 1993 because of a toxic isoniazid (INH) exposure. Review of the available medical charts of 33 patients revealed that median age was 19 years, 27 (82%) were females, and 24 (83%) were taking INH chemoprophylaxis for tuberculosis infection. Twenty-two patients had seizures. Twenty-seven (82%) patients had attempted suicide using INH, and another three patients had intentionally misused INH by making up missed doses at one time. All patients survived. Physicians should be aware of the potential for INH toxicity and should assess their patients' current mental and psychosocial status when prescribing it. INH toxicity should be considered when young patients, particularly females, present with unexplained intractable seizures, and treatment with pyridoxine should be given.

Adolescent↗
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Isoniazid-induced pure red cell aplasia.

The clinical courses of four individuals with pure red cell aplasia associated with isoniazid use are described. Erythroblastopenia in these individuals resolved following cessation of this antituberculous therapy. A clonal assay system that quantitates erythroid precursor cells was used to investigate the pathogenesis of the red cell aplasia in three of the patients. Using this technique, however, we were unsuccessful in demonstrating an inhibitory effect of acute phase serum, isoniazid or a combination of the two on erythroid colony formation. We conclude that isoniazid usage alone appears to be associated with a readily reversible form of acquired pure red cell aplasia. In addition, the results of our in vitro studies emphasize the limitations of bone marrow culture systems when used to implicate offending drugs in the production of drug related cytopenias.

Adult↗
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New approaches to the treatment of venous leg ulcers.

Increased understanding of the pathology of leg ulcers has made the differences in the pathologies of leg ulcers between patients more apparent. This article examines some areas of research that are advancing our understanding of the pathology of venous leg ulcers. The impact that this information is having on the development of new therapies and the implications for nursing practice are discussed.

Growth Substances↗