Branch retinal artery occlusion in a child.
Explore the source record for details and available documents.
Child↗
Biomedical subjects
R Hertzberg
Publications and source records attributed to R Hertzberg.
The identification and testing of interaction patterns.
This paper presents a method for identifying and assessing the significance of interaction patterns among various chemicals and chemical classes of importance to regulatory toxicologists. To this end, efforts were made to assemble and evaluate experimental data on toxicologically significant interactions, to use this information to characterize the consistency of toxicological interactions, and to define classes of compounds that display similar toxicological interactions. The motivation for this effort is to be able to propose hypotheses, which can be validated by experimentation, on how 2 or more chemicals will interact.
Databases, Factual↗
Refraction in ophthalmology.
Explore the source record for details and available documents.
Eye Diseases↗
Prenatal stress effects on functional development of the offspring.
Explore the source record for details and available documents.
Animals↗
The diffusion of ophthalmic laser in Australia.
This paper demonstrates the diffusion of ophthalmic laser into the Australian health care system. Australian ophthalmologists were quick to adopt the use of laser. Argon laser was introduced three years after its first use in the USA; YAG laser the same year as its use in the USA and Dye laser two years after its introduction in the USA. In the years 1975-84 there had been a gradual introduction of laser into ophthalmic practice growing from three to 39 in that period. From the end of 1984 to June 1986 the number increased by 68, an increase so sharp as almost to defy the classical S curve. The rapid rise can be attributed to its increased use in diabetic retinopathy, retinal vascular disease, senile macular degeneration, glaucoma and to perforate thickened posterior capsules.
Australia↗
Radial keratotomy--caveat emptor.
Explore the source record for details and available documents.
Adult↗
A short history of ophthalmic laser.
Explore the source record for details and available documents.
Eye Diseases↗
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA. Neither the equilibrium dialysis nor the unwinding measurement indicates any interaction between camptothecin and purified DNA. However, camptothecin induces extensive single strand DNA breaks in reactions containing purified mammalian DNA topoisomerase I. DNA breakage in vitro is immediate and reversible. Analyses of camptothecin-induced DNA breaks show that topoisomerase I is covalently linked to the 3' end of the broken DNA. In addition, camptothecin inhibits the catalytic activity of mammalian DNA topoisomerase I. We propose that camptothecin blocks the rejoining step of the breakage-reunion reaction of mammalian DNA topoisomerase I. This blockage results in the accumulation of a cleavable complex which resembles the transient intermediate proposed for eukaryotic DNA topoisomerase I. The inhibition of nucleic acid synthesis and the induction of DNA strand breaks observed in vivo may be related to the formation of this drug-induced cleavable complex.
Animals↗
Congenital ectropion uveae and glaucoma.
Congenital ectropion uveae is a rare condition which may be present in one or both eyes. If the patient is followed glaucoma will always be found to be present. Associated features which have been described are ptosis, Rieger's anomaly, Prader Willi syndrome, facial hemiatrophy and neurofibromatosis. This paper describes a patient followed for 18 years who had bilateral congenital ectropion uveae, bilateral ptosis, asthma and late onset of a dental defect.
Adolescent↗
Congenital cataract following German measles in the mother. Abstracts from the publications of the late Sir Norman McAlister Gregg.
This paper contains abstracts from publications of the late Sir Norman McAlister Gregg, published in 1941 and 1944, in which he demonstrated the association between rubella in pregnancy and defects in the baby. Besides cataract and retinopathy with which ophthalmologists are familiar, there occur deafness, deafmutism, cardiac defects, mental retardation, pulmonary and renal abnormalities and diabetes.
Cataract↗
Sarcoidosis.
(1) Sarcoidosis may affect any portion of the visual system. (2) Eye involvement may occur prior to, concurrent with, or after systemic manifestations. (3) Ocular manifestations may be the only complaint. (4) No age group is exempt. (5) Diagnosis may require a high index of suspicion. (6) Ocular sarcoidosis may be more common than is usually appreciated. (7) Ocular manifestations may be more common in black and oriental patients with sarcoidosis than in whites.
Conjunctival Diseases↗
Bielschowsky's sign. Its genesis and other observations by Bielschowsky.
Explore the source record for details and available documents.
Germany↗
Rubella and virus induced cataracts.
Gregg's discovery is acknowledged. The effects of the rubella virus on the lens is discussed, including virus persistence in the lens, post-natal development and post-natal spontaneous absorption of cataract. The effect of herpes simplex, herpes zoster, cytomegalic inclusion disease echovirus and smallpox on the lens are described.
Adolescent↗
The Sturge-Weber syndrome. Encephalofacial angiomatosis - report of a case.
Explore the source record for details and available documents.
Angiomatosis↗