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Biomedical subjects

R Henrion

Publications and source records attributed to R Henrion.

At least 127 records · Page 7Linked to original sources

[Early control laparoscopy after tubal microsurgery (author's transl)].

It is essential to carry out laparoscopic control to determine the result of plastic tubal surgery. This is classically done 12 to 18 months after the operation, yet it has been suggested that this control should be carried out earlier between the 4th and the 8th weeks or even on the 8th day following the operation. The authors have carried out 63 early control laparoscopies after microsurgical operations on the tube at different dates: 33 times between 4 and 8 weeks after the operation, 5 times between the 10th and the 13th day, and 25 times on the 8th day. They are in favour of early laparoscopic control with the reserve that it will require much more experience to tell whether the procedure is harmless.

Fallopian Tubes↗

[Maternal thinness and pregnancy].

In a retrospective study of 53 pregnant women who were constitutionally thin, there was a slight excess of premature deliveries. The birth weight of the term babies was lower than expected but there was no excess of serious perinatal complications. Adipose tissue was characteristically absent in these mothers. This may explain the results and be responsible for the failure to achieve optimum foetal development.

Adipose Tissue↗

[A fetal distress signal: decreased fetal movements. A case of antenatal anaemia (author's transl)].

The authors report an observation of antenatal anaemia which showed as fetal distress found by a decrease of fetal movements and confirmed by cardiotocography. At birth, the baby was very pale and has a severe anaemia. The authors have investigated the method introduced by Sadovsky for analysing fetal activity in which the woman counted her fetal movements in accordance with a time schedule. Normal fetal movements are an indication of fetal well-being. Decreased fetal movements may be an indication of chronic fetal asphyxia. In this case, cardiotocography has to be undertaken. Analysis of their results demonstrated the value of this method which appears to be useful particularly for the assessment of chronic fetal distress.

Adult↗

[Early amniocentesis, 1061 punctures and 1000 pregnancies].

The authors analysed 1061 early amniocentesis carried out during 1000 pregnancies. The indications were as follows: chromosomal abnormalities (79,6 p. 100), fetal karyotypes for X-linked diseases (4,7 p. 100), metabolic disorders (5,9 p. 100), amniotic fluid alpha-foetoprotein (9,8 p. 100) in neural tube defect or congenital nephrosis. Amniotic fluid was obtained on the first attempt in 98.2 p. 100 and on the second attempt in 100 p. 100. The fluid was heavily blood-stained in 1,7 p. 100, sanguinolent in 3,8 p. 100 and brownish in 2,40 p. 100. Cells were grown on the first attempt in 98 p. 100 and on the second attempt in 100 p. 100. The outcome of pregnancies was correlated with the indications of amniocentesis. The rate of spontaneous abortion is 1,7 p. 100, but only 6 of them can be due to amniocentesis (0,6 p. 100). Perinatal mortality was 1,8 p. 100: mortinatality (1,2 p. 100) and neonatal mortality (0.6 p. 100). All this fetal deaths have other causes. The fetal loss was 3,9 p. 100. Fetal morbidity was low: none fetal injuries, none cutaneous scar, few premature deliveries (1,6 p. 100), some malformations more or less serious (2,6 p. 100) with 4 congenital luxations of the hips (0,45 p 100). Maternal morbidity was limited at a greater cesarean section rate: 21 p. 100 (30 p. 100 in women 40 years old and more), none feto-maternal rhesus immunization was observed because immunoprophylaxis was strictly performed. The rate of therapeutic abortion was 4,6 p. 100 without any diagnostic error. Diagnostic accuracy was 100 p. 100. Several conditions are necessary to be the procedure safe accurate and reliable: appropriate genetic counseling, exact determination of gestational age (17 international weeks), sufficient volume of amniotic fluid counseling, exact determination of gestational age (17 international weeks), sufficient volume of amniotic fluid (uterus size: 12 cm), gynecologic examination by operator himself, perfect echography to localize the placenta and detect multiple gestations, adequately trained obstetrician, use of 20 gauge spinal needle, stric asepsis, experimented laboratory and experienced staff.

Amniocentesis↗

[Early amniocentesis in twin pregnancies (author's transl)].

Since 1972, we have performed 951 early amniocentesis in 902 pregnant women. There were 19 twin pregnancies, all diamniotic, representing 2.1% of the sample. Diagnosis was always suspected before the amniocentesis. It was confirmed by echography in the 14 cases in which this technique was used. Out of the first 5 cases without echography, we punctured only one sac. In the 14 last cases, the process was successful in 13 cases thanks:--the perfection of echography showing the exact location of the fetuses and the position of the septum--the injection of congo red (12 cases) or methylene blue (2 cases) into the first sac. The indications were as follows: chromosomal aberrations (14 cases) metabolic diseases (1 case), sex-linked disorders (1 cases) neural tube defects (3 cases). No complications due to amniocentesis were observed but three abortions and one fetal death occurred. The reason why is discussed. We have made only one therapeutic abortion.

Abortion, Spontaneous↗

Prenatal diagnosis of galactosemia.

We have monitored 3 pregnancies at risk for galactosemia by deficiency in Galactose-1-Phospho uridyl transferase. Galactosemia was diagnosed in the 1st case; heterozygoty in the 2nd, and a "double heterozygoty" in the 3rd. The latter is the first example of such a diagnosis. Post natal confirmation was obtained in the three cases. Arguments are given for the usefulness of this prenatal diagnosis.

Amniocentesis↗

[Foetoscopy (author's transl)].

Foetoscopy consists of the introduction into the ovular cavity, at the beginning of the second trimester of pregnancy, of an optical device in order to be able to observe the foetus and the foetal surface of the placenta. It may be used to detect certain foetal malformations which are not seen by echography and to collect foetal red cells by direct puncture of a placental vein. Its major indication is the prenatal diagnosis of homozygous forms of haemoglobinopathies: sickle cell disease and beta-thalassaemia. It is a dangerous investigation which requires great experience and perfect organisation.

Anemia, Sickle Cell↗

[The antenatal diagnosis of haemoglobinopathies. A preliminary study (author's transl)].

From now on antenatal diagnosis of haemoglobinopathies is possible. Fetal blood can be taken from the uterus from the 17th to the 20th week of the pregnancy by direct puncture of the placenta or placentocentesis or by selective puncture of a straight vein close to its insertion in the cord on the fetal surface of the placenta, using a fetoscope. Biochemical techniques today allow us to detect beta thalassaemia major (with total absence of synthesis or with synthesis of less than 2 per cent of the beta A chain of haemoglobin by the fetus) and drepanocytosis (which is the synthesis of the chain beta S by the in the absence of production of the chain beta A). It is possible in cases where the fetal blood that has been taken is seriously contaminated by maternal blood (which is often the case with direct punctures) by using purification methods to increase the proportion of fetal red blood cells in the sample by eliminating adult reticulocytes which could cause errors in diagnosis. There are several centres where this type of diagnosis is being carried out. Some of them now have two years' experience and their results are encouraging. In spite of their difficulty these methods of investigation can allow couples at risk to have normal children or heterozygous infants. They can help them to avoid the need for termination of pregnancy or permanent contraception.

Anemia, Sickle Cell↗

[Progress in the treatment of tubal sterility: microsurgery (author's transl)].

During the last few years microsurgery has evoked general enthusiasm in several surgical specialities and especially in plastic surgery. This is also true of gynaecology, where it is used for the surgery of sterility. Tubal microsurgery improves the results of operations by ensuring that the anatomical reconstruction shall be more precise and by lessening the amount of adhesions and secondary fibrosis. The first results that have been published prove this. The superiority of these difficult techniques is especially demonstrated by tubal recanalisations effected after sterilisation when the anastomosis is made in healthy tissue, being from the isthmus to the isthmus or from the isthmus to the uterus. Microsurgery is also the sole hope for the surgery of tubes that are at present inoperable. It will effect transplantation of the tube as soon as the problem of rejection has been solved.

Fallopian Tubes↗