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Biomedical subjects

R Henderson

Publications and source records attributed to R Henderson.

At least 217 records · Page 12Linked to original sources
PubMed1978

Evaluation of workers exposed to elemental mercury using quantitative tests of tremor and neuromuscular functions.

Workers exposed to metallic mercury vapor were subjects for tremor, EMG, and psychomotor tests. Regression analysis revealed statistically significant trends in these test results related to workers' urine mercury histories. Effects were subclinical, functionally insignificant and most associated with those workers whose urine mercury had exceeded 0.5 mg/L in the previous year. In agreement with previous reports, effects were reversible upon reduction of mercury exposure.

Adult↗
PubMed1976

Tension pneumothorax: a teaching model.

A TPT induced in a small rabbit is an excellent teaching model for the treatment of a TPT in the small human neonate. Pediatric housestaff, neonatal nurses, and others have utilized this model to gain confidence and expertise in the diagnosis and treatment of TPT. The rabbit model is inexpensive, readily available, and recreates the clinical condition of a TPT in an educational environment.

Animals↗
PubMed1975

Three-dimensional model of purple membrane obtained by electron microscopy.

A 7-A resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, alpha-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the spaces between the protein molecules.

Bacterial Proteins↗
PubMed1974

Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.

The effects of monovalent, divalent, and trivalent cations on the binding of tetrodotoxin and saxitoxin to intact nerves and to a preparation of solubilized nerve membranes have been examined. All eight divalent and trivalent cations tested, and the monovalent ions Li(+), Tl(+), and H(+) appear to compete reversibly with the toxins for their binding site. The ability of lithium to reduce toxin binding is paralleled by its ability to reduce tetrodotoxin-sensitive ion fluxes through the nerve membrane. We conclude that the toxins act at a metal cation binding site in the sodium channel and suggest that this site is the principal coordination site for cations (normally Na(+) ions) as they pass through the membrane during an action potential. The dissociation constant for Li(+) is 0.1-0.2 M and for Na(+) > 0.6 M, reflecting the weak binding necessary for rapid passage of sodium ions through the channel.

Animals↗