[Development of monoclonal antibodies].
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Biomedical subjects
Publications and source records attributed to R Hemmer.
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Hydrocephalus occlusus in children is caused by obstructions of the aqueduct and occasionally by cystic deformations of the posterior cranial cavre presented which were initially discovered by computerized axial tomography (CAT). The value of CAT becomes obvious since it can clearly demonstrate cystic and other lesions, size of ventricles and the course of a hydrocephalus. The method is non-invasive and there is no stress for the patient at all.
Over a period of 15 years, during which some 1000 operations were performed, CSF-drainage systems were able to be removed in 40 of a total of 444 children with communicating hydrocephalus or hydrocephalus associated with myelomeningocele. Shunts were removed from 26 children in the former group, of whom 17 continued to be compensated; in the latter group there were 14 removals, all of whom remained compensated. It is stressed that true compensation can be proven only by continuous measurement of ventricular fluid pressure over periods of several hours or at intervals of days or weeks, and four cases are discussed in which decompensation occurred, in two cases with fatal results.
We treated a patient who had a very rare finding: the development of a malignoma out of the capsules of the subdural hygroma covering the right occipitotemporal brain. Lumbar encephalography and arteriography confirmed the fact that surgery was necessary. A subdural-auricular shunt was performed and revised 2 years later. During the second operation, the external and internal capsules were removed in addition to the shunt. 3 years later the hygroma and large capsules were removed again and a ventricular-subdural drainage performed. 1 year later once more a subdural-auricular shunt was performed. 10 months later a tumour was found to be a pseudomucinous liposarcoma with large hyperchromatic nuclei and oval cells with large vacuoles of neutral fat. Renewed growth of the tumour led to the child's death. The histological and macroscopic findings of the capsules suggest the development of a malignoma within the last 3 years.
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Follow-up examinations of 82 children after surgery for subdjral effusions show a varied degree of retardation of motor- and speech-development. This corresponds to neurologic signs of varying severity. Preoperative EEG findings are improved both in pre-school- and school children. Disturbance of motor and intellectual development as a rule corresponds to severe EEG changes. Among pre-school children 35% had an IQ below 69%, among school-children 36%. But their occupational chances cannot yet be finally assessed. Children with large effusions (over 50 ml) and extensive capsules show a higher percentage of retardation. Present results do not establish relations between site of effusion, frequency of recurrence and mental development.
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Total and differential counts of the peritoneal cells of male and female BALB/c mice aged 10 days to over 2 years demonstrate that the increase in cell number that occurs in mice over 2 months old is due entirely to an increase in lymphocytes. The number of peritoneal macrophages in BALB/c females is maintained at a constant level for 22 months. The stability of the macrophage population in contrast to the increase in numbers of lymphocytes suggests that the body pools of these two cell types are not related.