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Biomedical subjects

R Heidrich

Publications and source records attributed to R Heidrich.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Acute toxoplasmosis outbreak in rabbit flocks].

Acute toxoplasmosis occurred in 2-18 month old domestic rabbits of 15 flocks entailing losses of 3-66%. Pathomorphological examinations of 49 rabbits revealed lesions of a generalized granulomatous-necrotizing toxoplasmosis with spleen, liver, lungs and lymphonodes mainly affected. Similarities existed to pseudotuberculosis. The spleen was massively packed with pseudocysts and cysts of Toxoplasma. Electronmicroscopic examinations of organ specimens fixed in formalin assured the identity of Toxoplasma and serological tests (CFT, SFT, IFAT) as well as the mouse test confirmed it.

Animals↗
PubMed1980

[Problem of so-called pseudotumor cerebri].

A brief survey on the concept of the so-called pseudotumour cerebri is given, referring to a great number of synonyms. On the basis of the clinical data of 70 patients with diseases of the intra- and extracranial organs and without a recognisable basic disease, a continous development of the increase in the brain pressure from only subjective complaints to the syndrome of the benign intracranial hypertension in an extended sense and the most severe disease pictures with a lethal outcome are discussed. For lethal courses the term of malignant intracranial hypertension is suggested and the importance of computer tomography in the differential diagnosis and supervision of unclear brain pressure increases is pointed out.

Adolescent↗
PubMed1979

[Fusiform arterial dilations of the vessels of the posterior cranial fossa].

In a 28-year-old woman with symptomatic cerebral convulsions, vertebral angiography showed two spindle-like dilatations which are probably located in the vascular province of the A. cerebelli superior. The EEG showed convulsive activities, the PEG a beginning hydrocephalus. Neurological findings and fundoscopy were normal. Lues could be ruled out. Differentiation from a cerebral phlebectasia, which is also rare, was reliably possible. An association between the vascular dilatations and the convulsions is not assumed.

Adult↗
PubMed1979

[Thromboelastographic and immunologic fibrinolysis determinations in inflammatory-changed and artificial blood stained cerebrospinal fluids using fibrinogen substrate].

In in-vitro long-term tests, the free fibrinolytic activity was determined from inflammatory-changed and blood stained cerebrospinal fluids in which partly fibrinogen concentrations insufficient for the enzyme-catalysed fibrinolytic reaction were present, using after addition of substrate (fibrinogen, plasma) thrombelastography and fibrin degradation products (FDP) recording. The results confirm a free fibrinolytic activity in many inflammatory-changed and blood stained cerebrospinal fluids. The difference in the results obtained with reaction preparations with substrate and those with too low fibrinogen concentrations are discussed.

Central Nervous System Diseases↗
PubMed1978

[Fibrin(ogen degradation product concentration (SFP) as a diagnostic parameter for the differentiation of artifical and essential blood in cerebrospinal fluid].

The fibrin(ogen) degradation product concentration is another differential-diagnosis parameter for distinguishing between artificially blood-stained and essentially blood-stained CSF. Determination of the fibrin(ogen) degradation product concentration has been found to be a reliable method of recognizing natively and artificially blood-stained CSF as being different.

Blood↗
PubMed1978

[Arteriovenous malformations in the region of the external carotid artery].

This article reports two cases of extracranial angiomatous vascular malformation, with blood being conveyed thereto by the external carotid artery. Visible and palpable clusters of dilated and pulsating vessels in the scalp or jugular region as well as vascular murmur are of major importance for clinical diagnosis. Conditions of flow may be objectified with the use of angiography. Therefore, the radiography of vessels should always be used to reliably determine the absence of combined extra- and intracranial vascular malformations.

Adult↗
PubMed1977

[In-vitro experiments on the clarification of the fibrinolytic activity in normal cerebrospinal fluid].

A direct and indirect detection of plasmin in native CSF was not possible by the thrombelastographic and hot fibrin agar plate method and by electroimmunodiffusion analysis using Laurell's method of fibrin degradation product determination, respectively. The same method was used to determine concentrations of plasminogen and fibrinogen. The CSF, which were retrospectively judged to be normal, neither showed plasmin activity nor exhibited plasminogen and fibrinogen concentrations. Therefore, the liqour possesses only a plasminogen activator protein and does not represent a fibrinolytically active CSF.

Cerebrospinal Fluid↗
PubMed1977

[In vitro studies to elucidate the fibrinolytic activity in cerebrospinal fluid altered by inflammation and hemorrhage and having pathologic protein values].

Using selectively immunological methods, it was possible, through FSP determination, for plasmin activities and plasminogen concentrations to be occasionally and exclusively detected in inflammatorily altered liquores and in bloody liquores, respectively. Thus, bloody cerebrospinal fluid, in contrast with inflammatorily altered liquor, usually shows free fibrinolytic activity, so that antifibrinolytic therapy of intracranial aneurysmal hemorrhage is pathophysiologically justifiable.

Central Nervous System Diseases↗
PubMed1977

[Postoperative paralysis of the bronchial plexus due to positioning].

A survey of the literature on problems of postoperative Duchenne-Erb paralyses caused by particular forms of arm positioning is followed by a report on observations made by the authors on a total of eleven patients. The paralyses observed were above all those of muscles of the Duchenne-Erb group. In four cases there were observed musculocutaneous paralyses. The tendency for reinnervation was good to excellent. Responsible for the development of paralysis was, in eight cases, the unphysiologic positioning of the arm during anesthesia and, as an additional straining moment, either the pressing down of the shoulders for Trendelenburg's position of the retroflection of the head in operations for struma. In three cases there was observed an involvement of that arm which had to be subjected to hyperabduction for the purpose of insuring free access to the site of operation. The careful analysis of causes requires important prophylactic considerations to be made. Also, consideration should be given to consequences in connection with insurance law, since the development of paralyses is in direct contradistinction to the risk involved in a surgical operation.

Adult↗
PubMed1977

[Hemostatic processes in aneurysmal hemorrhages].

Pathogenetic, diagnostic, and therapeutic problems and questions associated with ruptured cerebral aneurysms assume good knowledge of hemostatic processes. The three factors affecting hemostasia, namely, vasoactive, coagulative, and fibrinolytic risk factors in the blood, cerebro--spinal fluid, and at the site of damage to the vessel wall, are discussed withparticular reference to a thrombosing aneurysm. In the case of secondary hemorrhages it is necessary to determine the cause or pathogenesis, respectively, of the disturbance of coagulation or increase in fibrinolysis in order to be able to take suitable therapeutic measures and reduce the risk of secondary bleeding occurring within the first critical weeks after aneurysmal rupture.

Antifibrinolytic Agents↗
PubMed1976

[Artificial intranasal bacterial invasion in the newborn calf. 2. Artificial bacterial invasion using gram-positive and gram-negative strains].

A micrococcal and a diplocaccal strain isolated from the nasal space of a clinically intact nursed calf were used for artificial bacterial invasion in the first phase of the experiment. Application of bacterial suspension prepared from those strains had no effect upon the rise of coli counts in the nasal secretion of nursed calves during their first days of age nor upon the morbidity or mortality of all 677 test animals in comparison to 665 controls. Therefore, an avirulent E.-coli strain was used in subsequent bacterial invasion experiments. The strain was retrievable up to the seventh day of age, the count having been about 10(5) bacteria per gram nasal secretion. Application of a bacterial suspension prepared from that E.-coli strain did not reduce morbidity and mortality among 820 test animals that were compared to 809 controls. Results are discussed in this paper with reference to literature.

Animals↗
PubMed1976

[Intracerebral measurement of electric tensions following peripheral electric injury].

The present research has originated from observing a 25-year-old man who - after an electrotrauma-- showed a hydrocephalus internus in the pneumoencephalogram. The review of the literature available at that time resulted in obtaining only one information concerning this nexus of related problems; thus the search of patients suffering from this trauma began, but as well experiments on animals. Most of the cats being injured by A.C. actually showed a dilatation of the lateral ventricles. Further experiments on dogs have shown that not only in case of transcerebral but also of peripheral injuries by electric currents of certain strength, distinct states of paling on the brain surface could be observed occurring in consequences of the extreme vasosoconstriction of the meningeal vessels. By a further series of experiments on dogs, there was finally demonstrated that also after peripheral electric irritations resp. injuries of different variations, electric tensions in the brain can be measured by intracerebrally installed electrodes at varying irritatnt voltages; up to now, this possibility has been in contest. Neuropathological investigations showed intracerebral and subarachnoid haemorrhages of different size in all injured animals.

Animals↗
PubMed1976

[Neuropathologic findings after electrotrauma in dogs].

The authors report the results of morphological studies of the brains of dogs on which transcerebral or peripheral electrotraumata were inflicted and which were killed immediately after completion of the experiment. Subarachnoidal and intracerebral hemorrhages were observed in the two groups of experimental animals. Hemorrhages were much less intense in those cases in which so-called peripheral injuries were inflicted on the animals. However, it is reasonable to expect late and permanent functional and morphological damage to the central nervous system to be produced even in those cases where electric current is not caused to flow directly through the brain. This should be carefully considered in any attempt to determine the consequences of electrotraumata.

Animals↗